Hospital Survival After Surgical Repair of Truncus Arteriosus with Interrupted Aortic Arch: Results from a Multi-institutional Database

Jones, Brandon A; Conaway, Mark R.; Spaeder, Michael C.; Dean, Peter N.

doi:10.1007/s00246-021-02582-5

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…The most common were tetralogy of Fallot, ventricular septal defect with pulmonary atresia, persistent truncus arteriosus and interrupted aortic arch type B (Table 2). It is worth noting that the most common causes of death in 22q11.2DS were reported for cardiovascular patients with major congenital heart diseases who died at a significantly younger median age [9][10]. In the presented cases, the neonate with common truncus arteriosus died at the age of two months (Case 3).…”

Section: Discussionmentioning

confidence: 81%

Neonatal manifestation of 22q11.2 deletion syndrome – four case reports and a mini-literature review

Wójtowicz‐Marzec¹,

Wysokińska²,

Wysokiński³

2023

Ann Agric Environ Med.

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A genetic disorder caused by the microdeletion of the long arm of 22th chromosome is the most common microdeletion syndrome in humans. It is estimated that 22q11.2 deletion affects one in every 1,000 foetales and one in 4,000 live births. During the neonatal period, the 22q11.2 deletion syndrome manifests itself in children in the form of dysmorphic facial features, and the results of ultrasound imaging tests reveal thymus hypoplasia, urinary tract disorders or brain impairments. The picture is completed by congenital heart diseases which indicate a high probability of the syndrome. This report describes four cases of newborns with 22q11.2 syndrome, presenting with a variety of clinical findings typical for this genetic disorder. The patients present symptoms ranging from mild to life-threatening conditions. The severity of the congenital heart defect determines the survival rate in infancy. Each needs of each patient must be tailored to his or her specific medical problems. A holistic approach, addressing medical and behavioural needs, can be very helpful.

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Section: Discussionmentioning

confidence: 81%