Hospitalizaciones por hipoglucemia grave en pacientes con diabetes mellitus en España

Lindner, Lena M E; García-Sánchez, Raquel; Álvarez, Cristina Galeano; Betegón, Luis Antonio Acosta; Badı́a, Xavier

doi:10.1016/j.rce.2013.02.015

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…The frequency of hypoglycemic events was described in eight studies. An incidence of 1.82 episodes per 10,000 patients per year for SH was reported by Lindner et al [ 25 ]. Orozco-Beltrán et al reported an annual frequency of 0.30–0.40 events per year for SH, and 18.30–42.10 events per year for NSH [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Sicras-Mainar et al reported that 0.50% of patients with T2DM needed to be hospitalized, among whom 1.00% had to be treated in the specialized care departments, and 34.10% attended medical visits in primary care settings over a period of 2 years [ 22 ]. Lindler et al reported that 6.34% and 5.01% of the patients with T1DM and T2DM, respectively, required hospitalization [ 25 ]. Orozco-Beltrán et al reported that among the respondents with either T1DM or T2DM, 30% required emergency hospital visits and 19% were admitted to hospital because of their hypoglycemia [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of the 15 publications (14 studies) included in the SLR, six studies focused exclusively on data from patients with type 2 DM (T2DM) [19–24] and five studies reported combined data from patients with either type 1 DM (T1DM) or T2DM [25–30]. Only two studies highlighted data exclusively for patients with T1DM [31, 32], and one study reported neonatal hypoglycemia [33].…”

Section: Resultsmentioning

confidence: 99%

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Epidemiology, Quality of Life, and Costs Associated with Hypoglycemia in Patients with Diabetes in Spain: A Systematic Literature Review

et al. 2019

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Objective To assess the burden of hypoglycemia in patients with diabetes mellitus (DM) in Spain, including epidemiological data and information relating to healthcare resource utilization (HRU) and costs, and patients’ quality of life (QoL). Methods A systematic literature review (SLR) was conducted to identify studies that included original information on epidemiology, HRU and costs, and/or QoL associated with hypoglycemia in patients with DM in Spain, published in either Spanish or English, between January 2007 and April 2017. Results Fifteen articles, involving 14 studies, were identified in the SLR and included in the analysis. The estimated rate of severe hypoglycemia (SH) events per patient per year ranged from 0.90 to 1.50 in patients with type 1 DM (T1DM) and from 0.30 to 0.63 in patients with type 2 DM (T2DM). The data on HRU differed extensively between studies, making it difficult to draw a conclusion. Total costs per SH event ranged from €409.97 in patients with T1DM to €713.10 in patients with DM. Work absence was reported in 11.80–18% of the working patients. Further, patients who experienced hypoglycemic events expressed a higher fear and had a poorer QoL than those who did not report these events. Conclusion Although the data included in the SLR were difficult to synthesize due to heterogeneity of the study designs and patient characteristics in the 14 studies, our search identified a high burden associated with hypoglycemic events in terms of HRU and costs, and patients’ QoL. Further research is recommended to reach a consensus on hypoglycemia definition and study design to provide robust evidence on the burden of hypoglycemia and to accurately weigh the impact of this acute complication in Spain. Funding Eli Lilly and Company.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Epidemiology, Quality of Life, and Costs Associated with Hypoglycemia in Patients with Diabetes in Spain: A Systematic Literature Review

et al. 2019

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“…The PHDB represents approximately 55% to 65% of the total NHS episodes per year. Inferential methodology is used to estimate the final universe of patients who have been hospitalized for each specific pathology [ 29 ]. This methodology estimates data on hospitalization for the total Spanish NHS universe, which were used in this study.…”

Section: Methodsmentioning

confidence: 99%

Excess hospitalizations and mortality associated with seasonal influenza in Spain, 2008–2018

et al. 2023

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Background Influenza may trigger complications, particularly in at-risk groups, potentially leading to hospitalization or death. However, due to lack of routine testing, influenza cases are infrequently coded with influenza-specific diagnosis. Statistical models using influenza activity as an explanatory variable can be used to estimate annual hospitalizations and deaths associated with influenza. Our study aimed to estimate the clinical and economic burden of severe influenza in Spain, considering such models. Methods The study comprised ten epidemic seasons (2008/2009–2017/2018) and used two approaches: (i) a direct method of estimating the seasonal influenza hospitalization, based on the number of National Health Service hospitalizations with influenza-specific International Classification of Diseases (ICD) codes (ICD-9: 487–488; ICD-10: J09-J11), as primary or secondary diagnosis; (ii) an indirect method of estimating excess hospitalizations and deaths using broader groups of ICD codes in time-series models, computed for six age groups and four groups of diagnoses: pneumonia or influenza (ICD-9: 480–488, 517.1; ICD-10: J09–J18), respiratory (ICD-9: 460–519; ICD-10: J00–J99), respiratory or cardiovascular (C&R, ICD-9: 390–459, 460–519; ICD-10: I00–I99, J00–J99), and all-cause. Means, excluding the H1N1pdm09 pandemic (2009/2010), are reported in this study. Results The mean number of hospitalizations with a diagnosis of influenza per season was 13,063, corresponding to 28.1 cases per 100,000 people. The mean direct annual cost of these hospitalizations was €45.7 million, of which 65.7% was generated by patients with comorbidities. Mean annual influenza-associated C&R hospitalizations were estimated at 34,894 (min: 16,546; max: 52,861), corresponding to 75.0 cases per 100,000 (95% confidence interval [CI]: 63.3–86.3) for all ages and 335.3 (95% CI: 293.2–377.5) in patients aged ≥ 65 years. We estimate 3.8 influenza-associated excess C&R hospitalizations for each hospitalization coded with an influenza-specific diagnosis in patients aged ≥ 65 years. The mean direct annual cost of the estimated excess C&R hospitalizations was €142.9 million for all ages and €115.9 million for patients aged ≥ 65 years. Mean annual influenza-associated all-cause mortality per 100,000 people was estimated at 27.7 for all ages. Conclusions Results suggest a relevant under-detected burden of influenza mostly in the elderly population, but not neglectable in younger people.

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“…The escalating incidence of hospitalizations among patients with DM due to complications and severe hypoglycemia has introduced a new dimension to the landscape of DM management [ 6 , 7 ]. Hospitalizations reflect immediate health risks and amplify medical expenses, underscoring the imperative to control healthcare costs associated with DM-related admissions.…”

Section: Introductionmentioning

confidence: 99%

Impact of frailty on mortality, hospitalization, cardiovascular events, and complications in patients with diabetes mellitus: a systematic review and meta-analysis

Miao,

Zhang,

Yin

et al. 2024

Diabetol Metab Syndr

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Background Several studies have focused on the impact of frailty on the health outcomes of individuals with diabetes mellitus (DM). This meta-analysis aims to systematically synthesize the existing evidence on frailty and its association with mortality, hospitalizations, cardiovascular diseases, and diabetic complications in DM. Methods A comprehensive search in PubMed, Embase, and SCOPUS was carried out to identify relevant studies assessing the impact of frailty on mortality, hospitalizations, complications, and cardiovascular events in individuals with DM. The quality of the included studies was evaluated using the New Castle Ottawa Scale. Results From the 22 studies included, our meta-analysis revealed significant associations between frailty and adverse outcomes in individuals with DM. The pooled hazard ratios for mortality and frailty showed a substantial effect size of 1.84 (95% CI 1.46–2.31). Similarly, the odds ratio for hospitalization and frailty demonstrated a significant risk with an effect size of 1.63 (95% CI 1.50–1.78). In addition, frailty was associated with an increased risk of developing diabetic nephropathy (HR, 3.17; 95% CI 1.16–8.68) and diabetic retinopathy (HR, 1.94; 95% CI 0.80–4.71). Conclusion Our results show a consistent link between frailty and increased mortality, heightened hospitalization rates, and higher risks of cardiovascular disease, diabetic nephropathy, and diabetic retinopathy for patients with DM. PROSPERO Registration Number: CRD42023485166

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Hospitalizaciones por hipoglucemia grave en pacientes con diabetes mellitus en España

Cited by 12 publications

References 21 publications

Epidemiology, Quality of Life, and Costs Associated with Hypoglycemia in Patients with Diabetes in Spain: A Systematic Literature Review

Epidemiology, Quality of Life, and Costs Associated with Hypoglycemia in Patients with Diabetes in Spain: A Systematic Literature Review

Excess hospitalizations and mortality associated with seasonal influenza in Spain, 2008–2018

Impact of frailty on mortality, hospitalization, cardiovascular events, and complications in patients with diabetes mellitus: a systematic review and meta-analysis

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