Hospitalization and mortality during the pandemic in chronic hemodialysis patients and the general population in Peru

Herrera-Añazco, Percy; Apolaya-Segura, Moisés; Bravo-Zúñiga, Jessica; Vásquez, Jule; Taype-Rondan, Álvaro

doi:10.1590/2175-8239-jbn-2022-0149en

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…In respect to short-term outcomes related to COVID-19 infection, according to Herrera-Anazco et al, dialysis patients showed higher rates of admission to hospital and mortality rates after COVID infection, compared with the remaining of population [30]. Other authors supported these ndings [4,5].…”

Section: Discussionmentioning

confidence: 91%

Predictors factors of COVID-19-associated mortality in dialysis patients: Importance of nutritional status

Russo,

Gabriel,

Gouveia

et al. 2024

Preprint

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Background Patients with comorbidities, such as chronic renal disease, are susceptible to severe COVID-19 infection. Dialysis patients have a high prevalence of malnutrition, and it has been demonstrated association between nutritional status and several unfavorable outcomes in this population. The aim of this study was to assess nutritional status through Malnutrition-Inflammation Score (MIS) and phase angle (PhA), along with demographic and biochemical indicators and verify whether they are predictive variables of outcomes in dialysis patients with COVID-19 infection. Methods An observational, retrospective, cross sectional type study was undertaken in a Nephrology and Dialysis center in a tertiary hospital at São Paulo city. We evaluated data from EMR from 37 dialysis patients who had COVID-19 infection (RT-PCR) between march 2020 and december 2021. A Logistic regression was used in order to evaluate risk factors associated with mortality. Then we compared with a cohort of 31 dialysis patients infected with COVID-19 in the post-vaccionation period. Results Regarding MIS, age, and phase angle (PhA), we observed that for each unit increase in MIS previously to COVID-19 infection, there was a 30% increase in mortality risk (adj OR = 1.3, CI 1.0-1.8, p = 0.068) and that patients above 65 years had 8 times higher chance to die (adj OR = 8.8, CI 0.8–102, p = 0.082). Yet, for each unit increase in PhA, there was a 50% decrease in death risk (adj OR = 0.5, IC 0.2–1.1, p = 0.097), although no significance was found after logistic regression. After immunization, we found a attenuation of impact of nutritional status after COVID-19 infection, as demonstrated by a small, non-significant increase in MIS score, and with a low hospitalization need and no death. Conclusions The present study demonstrated a trend that age is the main variable determining outcomes of COVID-19 infection in dialysis patients. Besides that, we demonstrated the importance of nutritional status (MIS e PhA), since it appears to increase mortality risk when baseline nutritional status is worse and compromised after the COVID-19 infection, which was clearly abrogated with vaccination.

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Section: Discussionmentioning

confidence: 91%

Predictors factors of COVID-19-associated mortality in dialysis patients: Importance of nutritional status

Russo,

Gabriel,

Gouveia

et al. 2024

Preprint

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Prevalence of hypertension and diabetes mellitus in Peruvian patients with chronic kidney disease: a systematic review and meta-analysis

León-Figueroa,

Aguirre-Milachay,

Barboza

et al. 2024

BMC Nephrol

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Background Chronic Kidney Disease (CKD) represents a major challenge for public health, with hypertension and diabetes being the main causes of its occurrence. Therefore, this study aims to determine the prevalence of hypertension (HTN) and diabetes mellitus (DM) in Peruvian patients with CKD. Methods A systematic search for studies about CKD in Peru was carried out in PubMed, Scopus, Embase, Web of Science, ScienceDirect, Google Scholar, Virtual Health Library (VHL), and Scielo from 2011 to December 2023. The protocol of this research was registered in the international registry of systematic reviews, the Prospective International Registry of Systematic Reviews (PROSPERO), with registration number CRD42023425118. Study selection, quality assessment, and data extraction were performed independently by two authors. Study quality was assessed using the Joanna Briggs Institute Statistical Meta-Analysis Assessment and Review Instrument. A random-effects model with inverse variance weighting was used to estimate the combined prevalence of HTN and DM in Peruvian patients with CKD. To analyze data heterogeneity, the I2 statistical test was used. Statistical analysis was performed with R version 4.2.3. Results A total of 1425 studies were retrieved, of which 23 were included in the final meta-analysis. A total of 43,321 patients with CKD were evaluated, of whom 52.22% were male and 47.78% were female. The combined prevalence of HTN in Peruvian patients with CKD was 38% (95% CI: 30–46%; 41,131 participants; 21 studies, I2 = 99%, p = 0), while the combined prevalence of DM in Peruvian patients with CKD was 33% (95% CI: 26–40%; 43,321 participants; 23 studies, I2 = 99%, p = 0). Conclusion Approximately one-third of Peruvian patients with CKD have HTN and DM. These findings highlight the importance of implementing prevention and control measures for these chronic noncommunicable diseases in the Peruvian population, such as promoting healthy lifestyles, encouraging early detection and proper management of hypertension and diabetes, and improving access to medical care and health services.

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Prevalence of hypertension and diabetes mellitus in Peruvian patients with chronic kidney disease: a systematic review and meta-analysis

León-Figueroa,

Aguirre-Milachay,

Barboza

et al. 2023

Preprint

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Background Chronic Kidney Disease (CKD) represents a major challenge for public health, with hypertension and diabetes being the main causes of its occurrence. Therefore, this study aims to determine the prevalence of hypertension and diabetes mellitus in Peruvian patients with CKD. Methods A systematic review and meta-analysis were performed. For this purpose, a systematic search was carried out in various databases, including PubMed, Scopus, Embase, Web of Science, ScienceDirect, Google Scholar, Virtual Health Library (VHL), and Scielo, until December 1, 2023. The search terms used were "chronic kidney disease" and "Peru". Study selection, quality assessment, and data extraction were performed independently by two authors. Study quality was assessed using the Joanna Briggs Institute Statistical Meta-Analysis Assessment and Review Instrument. To analyze data heterogeneity, the I2 statistical test was used. Statistical analysis was performed with R version 4.2.3. Results A total of 1425 studies were collected, of which 23 were included in the final meta-analysis. A total of 43321 patients with CKD were evaluated, of whom 52.22% were male and 47.78% were female. The combined prevalence of hypertension in Peruvian patients with CKD was 38% (95% CI: 30–46%; 41131 participants; 21 studies, I2 = 99%, p = 0), while the combined prevalence of diabetes mellitus in Peruvian patients with CKD was 33% (95% CI: 26-40%; 43321 participants; 23 studies, I2 = 99%, p = 0). Additionally, the combined prevalence of Peruvian men and women with CKD was 55% (95% CI: 52-57%; 43321 participants; 23 studies, I2 = 93%, p < 0.01) and 45% (95% CI: 43-48%; 43321 participants; 23 studies, I2 = 93%, p < 0.01), respectively. Conclusion In accordance with the study, the combined prevalence of hypertension and diabetes in Peruvian patients with CKD was 38% and 33%, respectively.

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Hospitalization and mortality during the pandemic in chronic hemodialysis patients and the general population in Peru

Cited by 3 publications

References 31 publications

Predictors factors of COVID-19-associated mortality in dialysis patients: Importance of nutritional status

Predictors factors of COVID-19-associated mortality in dialysis patients: Importance of nutritional status

Prevalence of hypertension and diabetes mellitus in Peruvian patients with chronic kidney disease: a systematic review and meta-analysis

Prevalence of hypertension and diabetes mellitus in Peruvian patients with chronic kidney disease: a systematic review and meta-analysis

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