Hospitalization, major complications and mortality in acute myocardial infarction patients during the COVID-19 era: A systematic review and meta-analysis

Pourasghari, Hamid; Tavolinejad, Hamed; Soleimanpour, Samira; Abdi, Zhaleh; Arabloo, Jalal; Bragazzi, Nicola Luigi; Behzadifar, Masoud; Rashedi, Sina; Omidi, Negar; Ayoubian, Ali; Tajdini, Masih; Ghorashi, Seyyed Mojtaba; Azari, Samad

doi:10.1016/j.ijcha.2022.101058

Cited by 16 publications

(14 citation statements)

References 70 publications

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“…Since myocarditis can present subclinical with minor or atypical symptoms [ 26 , 27 ], this hypothesis seems plausible. It is also strengthened by an increase seen in hospital mortality, both in our registry and in published data [ 22 , 28 – 30 ].…”

Section: Discussionsupporting

confidence: 72%

Myocarditis mortality with and without COVID-19: insights from a national registry

et al. 2022

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Background Myocarditis in context of a SARS-CoV-2 infection is vividly discussed in the literature. Real-world data however are sparse, and relevance of the myocarditis diagnosis to outcome in coronavirus disease (COVID-19) is unclear. Patients and methods Retrospective analysis of 75,304 patients hospitalized in Germany with myocarditis between 2007 and 2020 is reported by DESTATIS. Patients hospitalized between 01/2016 and 12/2019 served as reference cohort for the COVID-19 patients hospitalized in 2020. Results A total of 75,304 patients were hospitalized between 2007 and 2020 (age 42.5 years, 30.1% female, hospital mortality 2.4%). In the reference cohort, 24,474 patients (age 42.8 years, 29.5% female, hospital mortality 2.2%) were registered. In 2020, annual myocarditis hospitalizations dropped by 19.6% compared to reference (4921 vs. 6119 annual hospitalization), of which 443/4921 (9.0%) were connected to COVID-19. In 2020, hospital mortality of myocarditis in non-COVID-19 patients increased significantly compared to reference (2.9% vs. 2.2%, p = 0.008, OR 1.31, 95% CI 1.08–1.60). In COVID-19 myocarditis, hospital mortality was even higher compared to reference (13.5% vs. 2.2%, p < 0.001, OR 6.93, 95% CI 5.18–9.18). Conclusion The burden of patients with myocarditis and COVID-19 in 2020 was low. Hospital mortality was more than sixfold higher in patients with myocarditis and COVID-19 compared to those with myocarditis but without COVID-19. Graphical abstract

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Section: Discussionsupporting

confidence: 72%

Myocarditis mortality with and without COVID-19: insights from a national registry

et al. 2022

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“…A systematic review and meta-analysis [ 26 ] of the impact of the SARS-CoV-2 outbreak on the presentation and prognosis of patients with acute myocardial Infarction; including results of 61 studies published throughout the globe, also confirmed the reduction of admissions by 24% (IRR 0.76 [0.67-0.85]) with an impact on early survival (OR = 1.33[1.18- 1.51] in-hospital mortality p=0.02). Also in another meta-analysis conducted by Pourasghari H. et al [ 27 ], a 29% reduction of STEMI was found during the early pandemic period compared to the pre-pandemic period (OR = 0.71; p < 0.001). Meanwhile the STEMI mortality increased by 15% but not statistically significant (OR = 1.15; p = 0.035).…”

Section: Discussionmentioning

confidence: 95%

Ongoing COVID-19 Pandemic Effects on Admissions and In-Hospital Outcomes in Patients With ST-Elevation Myocardial Infarction (STEMI): An Albanian Observational Study

Simoni¹,

Alimehmeti²,

Ceka³

et al. 2022

Cureus

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BackgroundMultiple studies conducted worldwide and in Albania documented an important reduction of acute STelevation myocardial infarction (STEMI) admissions during the Coronavirus Disease 19 (COVID-19) pandemic. There are few studies regarding STEMI admissions and outcomes during the ongoing pandemic after the initial lockdown. We aimed to study STEMI admissions and in-hospital outcomes after the COVID-19 lockdown period. MethodsA retrospective single-center study was conducted, collecting data for all consecutive STEMI admissions from March 9th, (the first COVID-19 case) until April 30 th , the corresponding period of 2020 total lockdown, for years 2019 and 2021. The control period was considered the year 2019 [pre-pandemic (PP)] and the study period was in 2021 [ongoing pandemic (OP)]. The incidence rate ratio (IRR) 95% confidence interval (CI) was used to compare all-STEMI admissions, invasive procedures, and risk ratio (RR) 95% CI to compare the mortality and complications rate between the study and control period. ResultsThe study included 217 STEMI patients admitted in 2019, and 234 patients during the 2021 period. The overall-STEMI admissions IRR is in a similar range during the 2021 OP compared to the 2019 PP period IRR=1.07 (95%CI 0.90-1.28). Similar invasive procedures were observed during OP compared to PP period, respectively for coronary-angiography IRR= 1.07; (0.87-1.31), for all-PCI [1.12 (0.92-1.35)], and primary percutaneous coronary interventions ]. The STEMI death rate during OP compared to PP period was similar (7.3 vs. 7.4%), RR=1.01 (0.53-1.96), and a non-significant lower primary-PCI-death rate (4.0 vs 4.8%), RR= 0.83 (0.30-2.3)]. ConclusionsAfter the initial reduction of admissions and invasive procedures in STEMI patients during the 2020 lockdown period and the increase of all-STEMI mortality, the number of hospitalizations, invasive procedures, and mortality returned to a similar range during OP compared to the PP period despite a highly incident ongoing COVID-19 pandemic.

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“…Abdi et al . (2021)[ 16 ] also considered a wide range of special managerial competencies necessary for health care leaders with the prevalence of Covid-19 disease. Sengupta et al .…”

Section: Discussionmentioning

confidence: 99%

Iran's struggling health system in the policy of managing the COVID-19 pandemic

Pourasghari

Rezapour

Tahernezhad³

et al. 2022

Int J Prev Med

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Hospitalization, major complications and mortality in acute myocardial infarction patients during the COVID-19 era: A systematic review and meta-analysis

Cited by 16 publications

References 70 publications

Myocarditis mortality with and without COVID-19: insights from a national registry

Myocarditis mortality with and without COVID-19: insights from a national registry

Ongoing COVID-19 Pandemic Effects on Admissions and In-Hospital Outcomes in Patients With ST-Elevation Myocardial Infarction (STEMI): An Albanian Observational Study

Iran's struggling health system in the policy of managing the COVID-19 pandemic

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