Hospitalizations among people with Down syndrome: A nationwide population‐based study in Denmark

Hasle, Henrik; Correa, Adolfo; Schendel, Diana; Friedman, Jan M.; Olsen, Jørn; Rasmussen, Sonja A.

doi:10.1002/ajmg.a.35711

Cited by 36 publications

(47 citation statements)

References 37 publications

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“…Another population‐based study from Denmark showed that patients with DS had more than twice the hospitalisation rate and nearly three times hospital days when compared with the general population (Zhu et al . ). Interestingly, when categorising into age groups, the discrepancies were more pronounced during childhood and decreased as patients aged – i.e.…”

Section: Discussionmentioning

confidence: 97%

“…We found that male patients stayed in the hospital slightly longer than female patients, similar to previously reported (Zhu et al . ). Patients from healthcare‐related facilities presented at later ages than patients who came from home ( N = 22, 52.2 years vs. N = 15, 41.5 years, respectively); this is possibly due to patients with DS transitioning to healthcare‐related facilities from home settings when they become older.…”

Section: Discussionmentioning

confidence: 97%

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Hospitalisation of adults with Down syndrome: lesson from a 10‐year experience from a community hospital

Chenbhanich

Phupitakphol

et al. 2018

J intellect Disabil Res

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Background Life expectancy of individuals with Down syndrome (DS) has improved significantly over the past decades. However, there are sparse data documenting the co‐morbidities and hospitalisation of adult patients with DS in the literature. The aim of this study was to characterise the co‐morbidities and pattern of hospitalisation in adult patients with DS during a 10‐year period at the community hospital as well as to compare hospitalisation parameters with the general adult population during the same years. Method We reviewed the medical records of 81 hospitalisations from 37 patients with DS aged 21 to 68 years at Metrowest Medical Center during a 10‐year period and compared with those of the general adult population during the same time. Co‐morbidities were also described. Results Adults with DS had a mean age at admission of 48.6 ± 8.8 years with the median length of stay of 3 days (interquartile range 4 days). Male patients were hospitalised longer than female patients (mean 5.0 vs. 2.8 days; P < 0.05), and patients who lived at home were admitted at earlier ages than those who came from residential healthcare facility (mean 41.5 vs. 52.2 years; P < 0.001). The most common cause of hospitalisation was pneumonia/aspiration syndrome (29.6%), and the most common co‐morbidity was gastroesophageal reflux disease (GERD)/dysphagia (70.3%). Presence of GERD/dysphagia or seizure disorder was significantly associated with multiple admission and readmission within 1 month (P < 0.05). The mortality rate was 4.9%, and the rate of intensive care unit admission was 8.6%. Conclusions Our cohort did not show statistically significant different hospitalisation parameters such as inpatient mortality and average length of stay when compared with general adult population hospitalised at the same years. The care of adult patients with DS presents challenges in internal medicine due to its unique co‐morbid profile and signifies the importance of multidisciplinary approach. In order to improve the care of this patient population, their co‐morbidities, particularly GERD/dysphagia and seizure disorder, should be optimally managed and comprehensively addressed when patients are hospitalised.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Hospitalisation of adults with Down syndrome: lesson from a 10‐year experience from a community hospital

Chenbhanich

Phupitakphol

et al. 2018

J intellect Disabil Res

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“…Some, but not all body systems exhibit signs of premature ageing, and, while longevity in people with DS has improved appreciably, age-specific risk for mortality is considerably increased compared with other people with intellectual disabilities [38]. Prior approaches to the description of the distinct clinical profile of adults with DS were based either on population studies based on death certificate diagnoses, or hospital admission diagnoses [11,16,39], or on retrospective series focused on a particular set of disorders (ophthalmologic disorders, cardiovascular disorders, cognitive impairment, celiac disease, etc. ), leading occasionally to contradictory conclusions [23,24,32,33,37].…”

Section: Introductionmentioning

confidence: 99%

Clinical profile and main comorbidities of Spanish adults with Down syndrome

Asúa

Quero

Moldenhauer

et al. 2015

European Journal of Internal Medicine

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“…However, in neurotypical children, the mean delay for a diagnosis of juvenile rheumatoid arthritis/other arthritic conditions was only 0.7 years [23]. The significant health impact of DS is well described throughout the literature and the development of a secondary condition could risk further impairment, not only of physical health and well-being but also of cognitive and/or functional outcome for individuals with DS [24][25][26]. It is the responsibility of the primary care provider caring for the patients with DS to monitor for commonly associated conditions and to provide early diagnosis, intervention and initiation of treatment [27].…”

Section: Discussionmentioning

confidence: 99%

Pediatrician Use of Down Syndrome Health Supervision Guidelines

Herzig

Walker²,

TeKolste³

et al. 2017

Clin Pediatr

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Objective: The primary care of children with Down syndrome (DS) requires close attention to specific medical vulnerabilities to maximize quality of life and prevent secondary disability. To help optimize adulthood outcomes for children with DS, the AAP Council on Genetics published health supervision guidelines to promote standardized care that adheres to the latest evidence based information. Our primary objective was to determine primary care pediatrician comfort, familiarity and frequency of referral to the 2011 AAP health supervision guidelines for children with DS. A secondary objective was to identify interventions that would improve compliance. Methods:A voluntary, self-administered e-mail survey was distributed to Washington State AAP members using Survey Monkey. The questionnaire targeted information regarding demographics, guideline knowledge, perceived barriers to guideline utilization and interventions to improve use. General pediatricians living in Washington State with self-reported past, current or expected future experience with the pediatric DS population were included.Results: Our response rate was 17% (N=161). Approximately 80% of pediatricians reported being comfortable using guidelines. About 20% of pediatricians were unfamiliar with the guidelines and do not refer to them. An additional 20% refer to the guidelines only sometimes. When asked a specific question regarding a guideline recommendation, 72% answered incorrectly. Over three-quarters of participants reported that electronic health record reminders would be the most beneficial. Conclusions:Opportunities to improve general pediatrician awareness and utilization of the DS guidelines exist. The most beneficial perceived intervention among pediatricians is guideline integration into the electronic health record. Studies measuring compliance and awareness of guidelines with a variety of interventions will be necessary in the future.

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Hospitalizations among people with Down syndrome: A nationwide population‐based study in Denmark

Abstract: SummaryBackground-Most persons with Down syndrome (DS) now survive to adulthood, but their health care needs beyond childhood are not well described. We examined hospitalizations among persons with DS in Denmark.

Cited by 36 publications

References 37 publications

Hospitalisation of adults with Down syndrome: lesson from a 10‐year experience from a community hospital

Hospitalisation of adults with Down syndrome: lesson from a 10‐year experience from a community hospital

Clinical profile and main comorbidities of Spanish adults with Down syndrome

Pediatrician Use of Down Syndrome Health Supervision Guidelines

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