Hospitalizations associated with respiratory syncytial virus (RSV) and influenza in children, including children having a diagnosis of asthma

Goldstein, Édward; Finelli, Lyn; P, Liu; Karaca, Zeynal; Steiner, Claudia; Viboud, Cécile; Lipsitch, Marc

doi:10.1101/161067

2017

DOI: 10.1101/161067

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Hospitalizations associated with respiratory syncytial virus (RSV) and influenza in children, including children having a diagnosis of asthma

Édward Goldstein

Lyn Finelli

Liu P

et al.

Abstract: Background: There is uncertainty about the burden of hospitalization associated with RSV and influenza in children, including those with underlying medical conditions.

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2022

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Burden of respiratory syncytial virus-associated lower respiratory infections in children in Spain from 2012 to 2018

et al. 2022

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Background Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection (ALRI) leading to infant hospitalization, morbidity and postnatal mortality in children younger than 5 years of age worldwide. The aim of this study was to collect data on hospitalizations for RSV-related ALRI in children in Spain from 2012 to 2018. Methods We used the discharge reports from the Minimum Basic Data Set (MBDS) to retrospectively analyze hospital discharge data in children ≤ 14 years of age with a diagnosis of acute lower respiratory tract infection, based on the ICD-9-CM and ICD-10-CM diagnosis codes, from 2012 to 2018. Results A total of 190,474 children, 58.1% boys and 41.9% girls, were admitted for lower respiratory tract infections in Spain, including 118,731 cases of bronchiolitis, 53,972 cases of bronchitis, 3710 cases of RSV-positive pneumonia, and 14,061 cases of RSV infections. Of these, 92,426 children (48.5%) had laboratory-confirmed RSV infection. The mean case fatality rate was almost 6 times higher for pneumonia (0.6%) than for bronchiolitis (0.1%) or bronchitis (0.1%). A significant linear increase in the mean annual hospitalization rate for pneumonia of almost 15% per year was found, with no changes in the trend over the study period. Conclusions RSV-related respiratory infections remain a leading cause of infant hospitalization in Spain. Effective antiviral treatments and preventive vaccines are urgently needed for the management of RSV infection in children, especially for those aged 6 to 12 months.

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Burden of respiratory syncytial virus-associated lower respiratory infections in children in Spain from 2012 to 2018

et al. 2022

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Hospitalizations associated with respiratory syncytial virus (RSV) and influenza in children, including children having a diagnosis of asthma

Abstract: Background: There is uncertainty about the burden of hospitalization associated with RSV and influenza in children, including those with underlying medical conditions.

Cited by 1 publication

References 41 publications

Burden of respiratory syncytial virus-associated lower respiratory infections in children in Spain from 2012 to 2018

Burden of respiratory syncytial virus-associated lower respiratory infections in children in Spain from 2012 to 2018

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