Hospitalizations due to systemic connective tissue diseases: Secular trends and regional disparities in Sweden, 1998‐2016

Kiadaliri, Aliasghar Ahmad; Mohammad, Aladdin J; Englund, Martin

doi:10.1111/1756-185x.13341

Cited by 5 publications

(8 citation statements)

References 24 publications

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“…However, the overall reduction from 2011 to 2019 was relatively small (À4.8%) compared with another analysis from Sweden, which also used joinpoint analysis, in which the reduction was 57% in the whole study period (1998-2013). 14 Although the direct factors of this reduction were not evaluated in our study, a possible explanation is that previous therapies may have had a beneficial impact that contributed to less hospitalizations, together with the possibility that more expert outpatient care may prevent admissions, which may prevent around 13% of avoidable hospitalizations. 15 Previous studies, in other geographic regions, mainly Europe, have also reported a decrease in hospitalization trends in the last decade.…”

Section: Discussionmentioning

confidence: 83%

“…This aspect may have an impact on the slight reduction of hospitalizations compared to a more significant decrease in other countries. 14 Interestingly, in males with SLE, the hospitalization rates were stable over the period analyzed; however, the number of cases in this gender group was relatively small. A large sample size might show a different trend modification that must be shown in future research since men with SLE are at higher risk for some lupus morbidities, like renal and cardiovascular.…”

Section: Discussionmentioning

confidence: 88%

“…This is the first nationwide study evaluating a long period of hospitalizations in Mexico and one of the few reported in Latin America 23 Furthermore, we used joinpoint regression analysis, which is composed of a few continuous linear phases, and is often useful to describe changes in trend data, but which has been used only in one Swedish study. 14 In summary, hospitalization due to SLE increased from 2000 to 2011 overall, in younger patients and in females, while in male patients the hospitalization rate was stable. However, hospitalization due to SLE decreased from 2011 to 2019 among both sexes, but mainly in females, while in males the hospitalization rate was stable for almost all the study period.…”

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

Mendoza‐Pinto

Etchegaray‐Morales

Munguía‐Realpozo

et al. 2022

Lupus

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Background Hospitalizations due to systemic lupus erythematosus (SLE) incur substantial resource use. Hospitalization trends provide a key benchmark of the disease burden. However, there is little long-term data in Mexico. Therefore, we evaluated Mexican hospitalization trends for SLE during 2000–2019. Methods Hospitalization trends of SLE were studied using data from 2000 to 2019 releases of the National Dynamic Cubes of the General Direction of Health Information, which provides data on hospitalization discharges in Mexico. Patients aged ≥15 years hospitalized during the study period with a principal discharge diagnosis of SLE (ICD-10 code M32) were included. Results From 2000 to 2019, there were 17,081 hospitalizations for SLE, of which 87.6% were in females and 87% in subjects aged 15–44 years. From 2000 to 2019, the age-standardized hospitalization rate for patients with SLE increased from 0.38 per 100,000 persons to 0.65 per 100,000 persons with an average annual percentage change (APC) of 2.9% (95% CI 6.2–63.2). Although there was a significant uptrend from 2000 through 2011, there was a significant decline from 2011 to 2019 (APC: −4.8%, 95% CI −7.0% to −2.5%). Similar trends were identified in subjects aged 15–44 years and in both sexes. The length of stay and inpatient mortality decreased between 2000–2009 and 2010–2019. Conclusions Although there was a substantial increase in SLE hospitalizations in 2000–2019, in 2011–2019, a decreased trend was reported in younger patients and in females and males. The length of stay was also reduced.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

Mendoza‐Pinto

Etchegaray‐Morales

Munguía‐Realpozo

et al. 2022

Lupus

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“…The disorder, however, has a marked predilection for women and similar to SLE, the female:male ratio is approximately 9:1. The disease usually presents in middle age but may occur in children as well as the elderly (5,6).…”

Section: Introductionmentioning

confidence: 99%

Accuracy of minor salivary gland biopsy in the diagnosis of Sjögren syndrome

Edelstein¹,

Kilipiris²,

Macháleková³

et al. 2021

BLL

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The aim of this study was to fi nd out the correlation and evaluate the accuracy of labial minor salivary gland biopsy as a diagnostic tool in the multidisciplinary management of patients with Sjögren syndrome. MATERIALS AND METHODS: Patients, referred to our outpatient offi ce between January 2014 and December 2018 from a rheumatologist for biopsy examination, as part of the complex diagnostic plan for suspected Sjögren syndrome, were included in the current study. Each specimen was examined histomorphometrically by the pathologist to calculate the focus score describing the degree of salivary gland infl ammatory infi ltration. RESULTS: Fifty patients met the inclusion criteria. From the total number of patients, 39 presented with an established Sjögren syndrome by fulfi lling the revised American-European criteria. From those, 27 had a positive lip biopsy. The remaining 12 patients from the total group, who were diagnosed with Sjögren syndrome based on the same criteria, had a negative lip biopsy. CONCLUSION: The labial minor salivary gland biopsy is a valuable diagnostic tool to establish the diagnosis of Sjögren syndrome. However, a positive biopsy result must always be correlated with all the other diagnostic criteria to prove the exact diagnosis (Tab. 1, Fig. 4, Ref. 49).

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Characterizing clinical findings of Sjögren’s Disease patients in community practices using matched electronic dental-health record data

Felix Gomez,

Hugenberg,

Zunt

et al. 2023

PLoS ONE

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Established classifications exist to confirm Sjögren’s Disease (SD) (previously referred as Sjögren’s Syndrome) and recruit patients for research. However, no established classification exists for diagnosis in clinical settings causing delayed diagnosis. SD patients experience a huge dental disease burden impairing their quality of life. This study established criteria to characterize Indiana University School of Dentistry (IUSD) patients’ SD based on symptoms and signs in the electronic health record (EHR) data available through the state-wide Indiana health information exchange (IHIE). Association between SD diagnosis, and comorbidities including other autoimmune conditions, and documentation of SD diagnosis in electronic dental record (EDR) were also determined. The IUSD patients’ EDR were linked with their EHR data in the IHIE and queried for SD diagnostic ICD9/10 codes. The resulting cohorts’ EHR clinical findings were characterized and classified using diagnostic criteria based on clinical experts’ recommendations. Descriptive statistics were performed, and Chi-square tests determined the association between the different SD presentations and comorbidities including other autoimmune conditions. Eighty-three percent of IUSD patients had an EHR of which 377 patients had a SD diagnosis. They were characterized as positive (24%), uncertain (20%) and negative (56%) based on EHR clinical findings. Dry eyes and mouth were reported for 51% and positive Anti-Ro/SSA antibodies and anti-nuclear antibody (ANA) for 17% of this study cohort. One comorbidity was present in 98% and other autoimmune condition/s were present in 53% respectively. Significant differences were observed between the three SD clinical characteristics/classifications and certain medical and autoimmune conditions (p<0.05). Sixty-nine percent of patients’ EDR did not mention SD, highlighting the huge gap in reporting SD during dental care. This study of SD patients diagnosed in community practices characterized three different SD clinical presentations, which can be used to generate SD study cohorts for longitudinal studies using EHR data. The results emphasize the heterogenous SD clinical presentations and the need for further research to diagnose SD early in community practice settings where most people seek care.

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Hospitalizations due to systemic connective tissue diseases: Secular trends and regional disparities in Sweden, 1998‐2016

Abstract: There were substantial decreases in the absolute and relative burden of SCTD hospitalizations reflecting possible improvements in disease management in Sweden. The rising trend in PANRC among the youngest children warrants further investigation.

Cited by 5 publications

References 24 publications

Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

Accuracy of minor salivary gland biopsy in the diagnosis of Sjögren syndrome

Characterizing clinical findings of Sjögren’s Disease patients in community practices using matched electronic dental-health record data

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