Hospitalized Infants Who Hurt: A Sweet Solution With Oral Sucrose

Pasek, Tracy Ann; J, Huber

doi:10.4037/ccn2012912

Cited by 13 publications

(5 citation statements)

References 54 publications

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“…It was initially proposed that it modulates pain through mediators on the tongue by releasing beta‐endorphins, thereby inhibiting pain perception . However, this has not been confirmed by some studies .…”

Section: Introductionmentioning

confidence: 99%

Randomised crossover trial showed that using breast milk or sucrose provided the same analgesic effect in preterm infants of at least 28 weeks

et al. 2017

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Aim: Repeated, ongoing exposure to pain influences the growth, cognitive and motor functions, behaviour, personality and neurodevelopment of preterm infants. We compared the analgesic effects of expressed breast milk (EBM) and 24% oral sucrose on preterm neonates during venipuncture.Methods: This multicentre randomised, noninferiority, crossover trial focused on five neonatal university units in Madrid, Spain, from October 2013 to October 2014. It comprised 66 preterm infants born at less than 37 weeks and randomly split into two groups. They received either EBM or sucrose two minutes before venepuncture, together with nonnutritive sucking and swaddling, then the opposite procedure at a later point. Pain was measured with the premature infant pain profile (PIPP) and crying was also measured.Results: There were no statistically significant differences between the groups. The PIPP scores were seven (4-9) with breast milk and six (4-8.25) with sucrose (p = 0.28). The 11 infants born at under 28 weeks of age showed higher median scores of nine (9-14) for breast milk and four (4-7) for sucrose (p = 0.009).Conclusion: EBM and 24% sucrose had the same analgesic effect during venipuncture in most of the preterm neonates, but sucrose worked better in extremely preterm infants.

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Section: Introductionmentioning

confidence: 99%

Randomised crossover trial showed that using breast milk or sucrose provided the same analgesic effect in preterm infants of at least 28 weeks

et al. 2017

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“…All sweet solutions are administered in the same way, on the infants' lateral side of the tongue prior to or 2 min before the procedure through a syringe slowly over 30 s [9,18]. Another administration technique is through the use of non-nutritive sucking using paciier to improve its efectiveness [11,19].…”

Section: Sweet Solutions In the Clinical Setings And Guidelinesmentioning

confidence: 99%

Sweet Solution Analgesia

Nuseir¹,

Kassab²,

Al-Azzani³

2017

Pain Relief - From Analgesics to Alternative Therapies

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“…Sucrose is inexpensive, readily available, and effective and has no proven negative effects. Much evidence has shown it to be effective in reducing pain in hospitalized babies who undergo invasive procedures (Pasek and Huber, 2012). It can be used alone or in combination with analgesics and other nonpharmacological interventions to provide comfort and analgesia.…”

Section: Resultsmentioning

confidence: 99%