Hospitalized prevalence and 5-year mortality for IBD: Record linkage study

Button, Lori; Roberts, Stephen E.; Goldacre, Michael J; Akbari, Ashley; Rodgers, Sarah; Williams, John

doi:10.3748/wjg.v16.i4.431

Cited by 30 publications

(43 citation statements)

References 35 publications

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“…Among these, 125 studies were excluded (Figure ). Therefore, six studies that included a total of 741 743 patients were selected for full analysis (Table ). There were two record‐linkage clinical studies, three data‐based studies and one study based upon a nationwide audit .…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, six studies that included a total of 741 743 patients were selected for full analysis (Table ). There were two record‐linkage clinical studies, three data‐based studies and one study based upon a nationwide audit . Four studies reported 3‐month mortality, one study reported 12‐month mortality, and one study reported both 3‐ and 12‐month mortalities of ASUC.…”

Section: Resultsmentioning

confidence: 99%

“…There were two record‐linkage clinical studies, three data‐based studies and one study based upon a nationwide audit . Four studies reported 3‐month mortality, one study reported 12‐month mortality, and one study reported both 3‐ and 12‐month mortalities of ASUC. There were three European studies, all from the United Kingdom, and three studies performed in the United States of America.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review with meta‐analysis: mortality in acute severe ulcerative colitis

Dong

Metzger

Holsbø

et al. 2019

Aliment Pharmacol Ther

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Summary Background Acute severe ulcerative colitis (ASUC) is a life‐threatening condition. Mortality in ASUC decreased in published series but there is uncertainty as to whether this also applies to the real‐life setting. Aim To perform a systematic review and meta‐analysis of mortality in ASUC in studies from referral centres and in population‐based studies, separately and combined. A second aim was to identify risk factors of mortality in ASUC. Methods We searched pubmed and embase from 1998 to 2016, to identify studies that reported 3‐month or 12‐month mortalities of acute UC in adult patients treated in referral centres, and in population‐based studies. Results Six population‐based studies with 741 743 patients and 47 referral centre‐based studies with 2556 patients were included. The pooled 3‐month and 12‐month mortalities were respectively 0.84% and 1.01%. Advanced age was significantly associated with both 3 month and 12 month mortalities (OR = 1.15 per year, 95% CI: 1.10‐1.20 and OR = 1.19 per year, 95% CI: 1.15‐1.23 respectively). The pooled 3‐month and 12‐month mortalities were 0.78% and 0.85% in studies with median age of less than 50 and 2.81% and 4.17% in studies with median age of 50 or more, respectively. After adjustment for age, 3‐month and 12‐month mortalities did not differ between population‐based and referral centre‐based studies. Conclusions Mortality in acute severe ulcerative colitis is approximately 1%; it is higher in older patients. Efforts should be made to improve the care of elderly patients with severe UC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Systematic review with meta‐analysis: mortality in acute severe ulcerative colitis

Dong

Metzger

Holsbø

et al. 2019

Aliment Pharmacol Ther

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“…These data are incorporated along with other health and social services data in the Secure Anonymised Information Linkage (SAIL) Databank,33,34 funded by the Welsh Assembly Government since 2006 and stored on an IBM supercomputer in the College of Medicine, Swansea University. These data have been used as the basis of many published studies in international Medline journals 35–40. The hospital in-patient data used, the Patient Episode Database for Wales (PEDW), includes abstracts of in-patient and day case admissions to all National Health Service (NHS) hospitals in Wales.…”

Section: Methodsmentioning

confidence: 99%

The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors

Roberts

Akbari

Thorne

et al. 2013

Aliment Pharmacol Ther

191

156

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BackgroundThe incidence of acute pancreatitis has increased sharply in many European countries and the USA in recent years.AimTo establish trends in incidence and mortality for acute pancreatitis in Wales, UK, and to assess how incidence may be linked to factors including social deprivation, seasonal effects and alcohol consumption.MethodsUse of record linked inpatient, mortality and primary care data for 10 589 hospitalised cases of acute pancreatitis between 1999 and 2010.ResultsThe incidence of acute pancreatitis was 30.0 per 100 000 population overall, mortality was 6.4% at 60 days. Incidence increased significantly from 27.6 per 100 000 in 1999 to 36.4 in 2010 (average annual increase = 2.7% per year), there was little trend in mortality (0.2% average annual reduction). The largest increases in incidence were among women aged <35 years (7.9% per year) and men aged 35–44 (5.7%) and 45–54 (5.3%). Incidence was 1.9 times higher among the most deprived quintile of patients compared with the most affluent (3.9 times higher for alcoholic acute pancreatitis and 1.5 for gallstone acute pancreatitis). Acute pancreatitis was increased significantly during the Christmas and New Year weeks by 48% (95% CI = 24–77%) for alcoholic aetiology, but not for gallstone aetiology (9%). Alcoholic admissions were increased with higher consumption of spirits and beer, but not wine.ConclusionsThe study shows an elevated rate of alcoholic acute pancreatitis during the Christmas and New Year period. Acute pancreatitis continues to rise, most rapidly for young women, while alcoholic acute pancreatitis is linked strongly with social deprivation.

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“…Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease (IBD), which additionally includes Crohn's disease and indeterminate colitis, all characterized by idiopathic chronic inflammation of the gastrointestinal tract [1].…”

Section: Introductionmentioning

confidence: 99%

A Simple Noninvasive Score Predicts Disease Activity and Deep Remission in Ulcerative Colitis

et al. 2018

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Background: There is a need to use noninvasive markers in refining the management of ulcerative colitis to reduce the number of unnecessary colonoscopies, which facilitates the follow-up of activity and the response to treatment. Aim: Postulation of a sensitive, specific, simple and noninvasive score to monitor disease activity in ulcerative colitis. Methods: A case-control study was conducted: 168 patients with ulcerative colitis, 40 healthy individuals, and 60 patients for validation. Patients were divided into new diagnosis (n = 50), clinical remission (n = 60), and relapse (n = 58). The main outcome measures if the score correlates with clinical, endoscopic and histopathological characteristics and if it correlates with deep remission. Results: A scoring system was established composed of lactoferrin at a cutoff of 148.5 μg/mL, neutrophil lymphocyte ratio at a cutoff of 2.35, erythrocyte sedimentation rate at the first hour at a cutoff of 29.5 mm/h, C-reactive protein at a cutoff of 3.85 mg/L, mean platelet volume at a cutoff of 8.8 fL, fecal white blood cells at a cutoff of 9 cells/HPF, and fecal red blood cells at a cutoff of 6 cells/HPF. A score ≥5 can detect 94% of cases of UC as determined by the receiver operating characteristic curve with a sensitivity of 94% and a specificity 100%, AUC 0.92, SE 0.05, p = 0.001, 95% CI 0.82–1.1. In the validation group, it identified severely affected patients with a sensitivity of 95% and a specificity of 85.7%. Conclusions: This easily applied and reproducible noninvasive activity score showed high performance in predicting disease activity and deep remission in ulcerative colitis.

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Hospitalized prevalence and 5-year mortality for IBD: Record linkage study

Abstract: CD and UC have distinct demographic profiles. The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency.

Cited by 30 publications

References 35 publications

Systematic review with meta‐analysis: mortality in acute severe ulcerative colitis

Systematic review with meta‐analysis: mortality in acute severe ulcerative colitis

The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors

A Simple Noninvasive Score Predicts Disease Activity and Deep Remission in Ulcerative Colitis

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