Hospitals and Laboratories on Paper-Based Sensors: A Mini Review

Zhang, Huaizu; Xia, Chengbin; Feng, Guangfu; Fang, Jun

doi:10.3390/s21185998

Cited by 13 publications

(6 citation statements)

References 86 publications

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“…The results also suggest that the process is a direct function of the rHbI-H 2 O concentration present in the scaffold collagen system. Future work in this direction includes producing a met-aquo rHbI collagen gel capable of being printed as single drops in polymer, cotton, or chromatographic paper, as has been done for other chemical systems [25,70,71]. The process determines H 2 S gas concentrations from different biological sources by measuring the rHbI-H 2 S concentration in the single drop moiety, using UV-Vis diffuse reflectance techniques, which are simple, nondestructive, and low-cost tools.…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin I from Lucina pectinata on Collagen Scaffold: A Prospective Hydrogen Sulfide Scavenger

Santiago

Cheeseborough

López‐Garriga

2022

Journal of Chemistry

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Hydrogen sulfide (H2S), independently of being a toxic gas with a characteristic smell of rotten eggs, is a crucial signaling molecule with significant physiological functions. Given the rapid diffusivity of the gas, it is a challenge to develop robust sensors and biomarkers to quantify free or bound H2S. In addition, there is the need to further develop a robust biosystem to efficiently trap or scavenge H2S from different producing environments. The work presented here uses recombinant met-aquo rHbI (rHbI-H2O) immobilization techniques on collagen to determine its ability to bind H2S due to its high affinity ( 1.24 × 10 8 M-1). The hemeprotein will function as a scavenger on this scaffold system. UV-Vis absorption and UV-Vis diffuse reflectance (%R) spectroscopy of rHbI-H2O and rHbI-sulfide (rHbI-H2S) complex in solution and collagen scaffold demonstrated that the heme chromophore retains its reactivity and properties. UV-Vis diffuse reflectance measurements, transformed using the Kubelka-Munk function (K-M function), show a linear correlation ( R 2 = 0.9987 and 0.9916) of rHbI-H2O and rHbI-H2S within concentrations from 1 μM to 35 μM for derivatives. The extraordinary affinity of rHbI-H2O for H2S suggests recombinant met-aquo HbI in a collagen scaffold is an excellent scavenger moiety for hydrogen sulfide. These findings give insight into H2S trapping using the rHbI-H2O-collagen scaffold, where the rHbI-H2S concentration can be determined. Future pathways are to work toward the development of a met-aquo rHbI collagen solution capable of being printed as single drops on polymer, cotton or chromatographic paper. Upon exposure of these matrixes to H2S, the rHbI-H2S complex is formed and its concentration determined using UV-Vis diffuse reflectance technique.

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Section: Discussionmentioning

confidence: 99%

Hemoglobin I from Lucina pectinata on Collagen Scaffold: A Prospective Hydrogen Sulfide Scavenger

Santiago

Cheeseborough

López‐Garriga

2022

Journal of Chemistry

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“…To better promote practical detection and on−site screening, it is necessary for a FAS to improve its sensitivity and efficiency. Paper is cheap and easy to preserve, with good biocompatibility and biodegradability [ 101 ]. These excellent peculiarities make it the best substrate for sensors.…”

Section: Aptamer Conjugate Recognition Techniquesmentioning

confidence: 99%

Advances in Aptamer-Based Conjugate Recognition Techniques for the Detection of Small Molecules in Food

Deng,

Ma,

Gong

et al. 2024

Foods

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Small molecules are significant risk factors for causing food safety issues, posing serious threats to human health. Sensitive screening for hazards is beneficial for enhancing public security. However, traditional detection methods are unable to meet the requirements for the field screening of small molecules. Therefore, it is necessary to develop applicable methods with high levels of sensitivity and specificity to identify the small molecules. Aptamers are short−chain nucleic acids that can specifically bind to small molecules. By utilizing aptamers to enhance the performance of recognition technology, it is possible to achieve high selectivity and sensitivity levels when detecting small molecules. There have been several varieties of aptamer target recognition techniques developed to improve the ability to detect small molecules in recent years. This review focuses on the principles of detection platforms, classifies the conjugating methods between small molecules and aptamers, summarizes advancements in aptamer−based conjugate recognition techniques for the detection of small molecules in food, and seeks to provide emerging powerful tools in the field of point−of−care diagnostics.

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“…It should be noted that the field of paper-based sensors is developing rapidly, and significant progress has been made in the development of such sensors. At present, quite a lot of reviews on paper-based sensors have already been published [ 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. But most of them are aimed at considering electrochemical and optical sensors, biosensors, gas sensors, and strain sensors.…”

Section: Introductionmentioning

confidence: 99%

Paper-Based Humidity Sensors as Promising Flexible Devices: State of the Art: Part 1. General Consideration

Korotcenkov

2023

Nanomaterials

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In the first part of the review article “General considerations” we give information about conventional flexible platforms and consider the advantages and disadvantages of paper when used in humidity sensors, both as a substrate and as a humidity-sensitive material. This consideration shows that paper, especially nanopaper, is a very promising material for the development of low-cost flexible humidity sensors suitable for a wide range of applications. Various humidity-sensitive materials suitable for use in paper-based sensors are analyzed and the humidity-sensitive characteristics of paper and other humidity-sensitive materials are compared. Various configurations of humidity sensors that can be developed on the basis of paper are considered, and a description of the mechanisms of their operation is given. Next, we discuss the manufacturing features of paper-based humidity sensors. The main attention is paid to the consideration of such problems as patterning and electrode formation. It is shown that printing technologies are the most suitable for mass production of paper-based flexible humidity sensors. At the same time, these technologies are effective both in the formation of a humidity-sensitive layer and in the manufacture of electrodes.

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Hospitals and Laboratories on Paper-Based Sensors: A Mini Review

Cited by 13 publications

References 86 publications

Hemoglobin I from Lucina pectinata on Collagen Scaffold: A Prospective Hydrogen Sulfide Scavenger

Hemoglobin I from Lucina pectinata on Collagen Scaffold: A Prospective Hydrogen Sulfide Scavenger

Advances in Aptamer-Based Conjugate Recognition Techniques for the Detection of Small Molecules in Food

Paper-Based Humidity Sensors as Promising Flexible Devices: State of the Art: Part 1. General Consideration

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