Host biomarkers other than interferon gamma in QFT-TB supernatants for identifying active tuberculosis

Zhou, Yu; Zhang, Fujie; Shi, Hanlu; Wu, Peihao; Zhou, Yonglie

doi:10.1016/j.tube.2022.102256

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…A study that evaluated forty-eight cytokines, chemokines and growth factors showed that IL-2 was the biomarker most frequently included among the top seven biomarkers to detect Mtb-infected individuals, followed by IFN-γ [ 126 ]. A recent study that evaluated cytokines/chemokines other than IFN-ɣ in the supernatants of Quantiferon ® -TB showed that IL-2 along with RANTES Ag could be used as an alternative to differentiate ATB from TBI [ 140 ]. Nonetheless, some other studies failed to find IL-2 as a useful biomarker that can distinguish ATB from TBI [ 141 ].…”

Section: Evaluation Of Host-derived Biomarkersmentioning

confidence: 99%

Challenges and the Way forward in Diagnosis and Treatment of Tuberculosis Infection

et al. 2023

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Globally, it is estimated that one-quarter of the world’s population is latently infected with Mycobacterium tuberculosis (Mtb), also known as latent tuberculosis infection (LTBI). Recently, this condition has been referred to as tuberculosis infection (TBI), considering the dynamic spectrum of the infection, as 5–10% of the latently infected population will develop active TB (ATB). The chances of TBI development increase due to close contact with index TB patients. The emergence of multidrug-resistant TB (MDR-TB) and the risk of development of latent MDR-TB has further complicated the situation. Detection of TBI is challenging as the infected individual does not present symptoms. Currently, there is no gold standard for TBI diagnosis, and the only screening tests are tuberculin skin test (TST) and interferon gamma release assays (IGRAs). However, these tests have several limitations, including the inability to differentiate between ATB and TBI, false-positive results in BCG-vaccinated individuals (only for TST), false-negative results in children, elderly, and immunocompromised patients, and the inability to predict the progression to ATB, among others. Thus, new host markers and Mtb-specific antigens are being tested to develop new diagnostic methods. Besides screening, TBI therapy is a key intervention for TB control. However, the long-course treatment and associated side effects result in non-adherence to the treatment. Additionally, the latent MDR strains are not susceptible to the current TBI treatments, which add an additional challenge. This review discusses the current situation of TBI, as well as the challenges and efforts involved in its control.

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Section: Evaluation Of Host-derived Biomarkersmentioning

confidence: 99%

Challenges and the Way forward in Diagnosis and Treatment of Tuberculosis Infection

et al. 2023

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“…8 IFN-γ induces the production of multiple chemokines to activate cellular immunity to contain infection and prevent the spread of Mtb. 9 While abundant studies may exist in literature regarding exploring potential biomarkers for identifying TB from LTBI, and analysing the role of inflammatory factors [10][11][12] and chemokines 13,14 in TB, few studies have focused on immune differences between LTBI and healthy populations and the role they play in LTBI. Most of them were either cell-line 15 or animal studies, 16 and only few studies used human peripheral blood monocytes for experiments.…”

Section: Introductionmentioning

confidence: 99%

Association Studies of Serum Levels of TNF- α, IL-10, IFN-γ and CXCL 5 with Latent Tuberculosis Infection in Close Contacts

Razbek,

Daken,

Chen

et al. 2024

IDR

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Purpose Early recognition and treatment of latent tuberculosis infection(LTBI) is key to tuberculosis(TB) prevention. However, the emergence of LTBI is influenced by a combination of factors, of which the role of individual immune cytokines remains controversial. The aim of this study is to explore the influencing factors of LTBI and their effects with cytokines on LTBI. Patients and Methods Close contacts of tuberculosis in Urumqi City from 2021 to 2022 were selected for the study to conduct a field survey. It used logistic regression model to analyse the influencing factors of LTBI, principal component analysis to extract a composite indicators of cytokines, and structural equation modelling to explore the direct and indirect effects of cytokines and influencing factors on LTBI. Results LTBI infection rate of 33.3% among 288 TB close contacts. A multifactorial Logistic model showed that factors influencing LTBI included education, daily contact hours, eating animal liver, and drinking coffee ( P <0.05); After controlling for confounding factors and extracting composite indicators of cytokines using principal component analysis, CXCL5 and IFN-γ is a protective factor for LTBI(OR=0.572, P =0.047), IL-10 and TNF-α is a risk factor for LTBI(OR=2.119, P =0.010); Structural equation modelling shows drinking coffee, eating animal liver, daily contact hours, and IL-10 and TNF-α had direct effects on LTBI and educations had indirect effects on LTBI( P <0.05). Conclusion IL-10 and TNF-α are involved in the immune response and are directly related to LTBI. By monitoring the cytokine levels of TB close contacts and paying attention to their dietary habits and exposure, we can detect and intervene in LTBI at an early stage and control their progression to TB.

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Current status and future landscape of diagnosing tuberculosis infection

Kobashi

2023

Respiratory Investigation

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Host biomarkers other than interferon gamma in QFT-TB supernatants for identifying active tuberculosis

Cited by 5 publications

References 22 publications

Challenges and the Way forward in Diagnosis and Treatment of Tuberculosis Infection

Challenges and the Way forward in Diagnosis and Treatment of Tuberculosis Infection

Association Studies of Serum Levels of TNF- α, IL-10, IFN-γ and CXCL 5 with Latent Tuberculosis Infection in Close Contacts

Current status and future landscape of diagnosing tuberculosis infection

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