Host defence and effects of solutions on peritoneal cells

Coles, Gerald A.; Lewis, Sharon L.; Williams, Julie

doi:10.1007/978-94-011-0814-0_17

Cited by 18 publications

(17 citation statements)

References 133 publications

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“…They suggested that these levels were not caused by increased peritoneal loss, but by reduced synthesis. In our study, the levels of serum immunoglobulin and C3 did not decrease in adult patients, similar to results found by others [6,12,13,14].…”

Section: Discussionsupporting

confidence: 93%

“…In our study, the rate of peritonitis was very high in children, and these high rates were secondary to some patients having a high rate of peritonitis. Serum immunoglobulin and complement levels within the normal range have been repeatedly documented in adults undergoing peritoneal dialysis, despite substantial losses of immunoglobulins and C3 into the peritoneal dialysis effluent [6,12,13,14]. However, raised concentrations of IgG3 have been reported in adults [6].…”

Section: Discussionmentioning

confidence: 99%

“…Most studies of host defenses in the dialyzed peritoneum have been performed in adults, and have examined peritoneal macrophages and dialysate opsonins, such as IgG, complement, and fibronectin [1,5,6]. Patients maintained on chronic peritoneal dialysis (CPD) have been reported to have a variety of abnormalities in humoral immunity, including hypogammaglobulinemia, altered response to vaccination, and the selective absence of IgG2 [1,2,3,4,6].…”

Section: Introductionmentioning

confidence: 99%

“…Patients maintained on chronic peritoneal dialysis (CPD) have been reported to have a variety of abnormalities in humoral immunity, including hypogammaglobulinemia, altered response to vaccination, and the selective absence of IgG2 [1,2,3,4,6].…”

Section: Introductionmentioning

confidence: 99%

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Humoral immunity and frequency of peritonitis in chronic peritoneal dialysis patients

Poyrazoğlu

Düşünsel

Patıroğlu

et al. 2002

Pediatric Nephrology

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This study was designed to investigate the humoral immune status and immunological abnormalities in relation to the pathogenesis of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). The levels of serum and dialysate total protein, immunoglobulins (IgG, IgA, IgM, and IgG subgroups), and C3 were measured at baseline and at the end of the study in 12 children and 10 adult patients on CAPD. The relationship between the levels of immunoglobulin and C3 and the frequency of peritonitis was investigated. Peritonitis occurred at a frequency of one episode every 3.9 and 6.3 patient-months in children at the beginning and at the end of the study, respectively; however, the respective rates for adult patients were one episode every 5.6 and 9.8 patient-months. The levels of serum immunoglobulin and C3 were normal in adults at the beginning and at the end of the study. However, the levels of serum IgG were low in 4 of 12 pediatric patients. Of the 4 patients with low total IgG, IgA was low in 1 and IgM was low in 2 patients. Of 4 patients with low total IgG, 2 also had low IgG1 and IgG2. However, 3 of the patients with normal IgG had low IgG2 levels at the end of the study. The levels of C3 were low in 6 of 12 and in 3 of 10 pediatric patients at the beginning and at the end of the study, respectively. The protein levels of dialysate were increased at 1-year follow-up in both groups, but the difference was only statistically significant in adult patients (P<0.05). No correlation was found between the levels of serum and dialysate immunoglobulin and the frequency of peritonitis in either group. In this study, hypogammaglobulinemia and hypocomplementemia were determined in pediatric patients undergoing CAPD. Although these immunological deficits are not major factors in the occurrence of CAPD-related peritonitis, they may contribute to the frequency of peritonitis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Humoral immunity and frequency of peritonitis in chronic peritoneal dialysis patients

Poyrazoğlu

Düşünsel

Patıroğlu

et al. 2002

Pediatric Nephrology

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show abstract

“…Accordingly, lactate-containing PD solutions may be more likely to induce fibrosis and neovascularization than bicarbonate-containing solutions. pH It has been reported that exposure to peritoneal dialysis fluid at pH 5.3 results in significant functional impairment of cells involved in the peritoneal defense system [63,64]. We investigated the effects of pH on the growth of HPMCs and on the production of coagulation and fibrinolysis factors [42].…”

Section: Lactatementioning

confidence: 99%

Peritoneal damage by peritoneal dialysis solutions

Ito

Yorioka

2008

Clin Exp Nephrol

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Continuous ambulatory peritoneal dialysis is a well-accepted treatment for end-stage renal disease, but its long-term success is limited. Peritoneal sclerosis is still one of the most important complications of long-term peritoneal dialysis and the low biocompatibility of peritoneal dialysis solutions plays a major role in the development of such sclerosis. In this review, we summarize recent experimental data about the biocompatibility of peritoneal dialysis solutions.

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Peritoneal Infections, Hernias and Related Complications

Gokal

Replacement of Renal Function by Dialysis

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Host defence and effects of solutions on peritoneal cells

Cited by 18 publications

References 133 publications

Humoral immunity and frequency of peritonitis in chronic peritoneal dialysis patients

Humoral immunity and frequency of peritonitis in chronic peritoneal dialysis patients

Peritoneal damage by peritoneal dialysis solutions

Peritoneal Infections, Hernias and Related Complications

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