Host Defense Mechanisms in Gnotobiotic Animals

Bealmear, Patricia M.

doi:10.1007/978-1-4684-8652-0_11

Cited by 2 publications

(1 citation statement)

References 152 publications

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“…According to Ferket et al (2002), the YCW components might stimulate the gut-associated immune system by acting as a nonpathogenic microbial antigen, giving an adjuvant-like effect. Studies in mammals have described the importance of digestive microbial antigen stimulation on the development of lymphoid organ tissue (Bealmear, 1980;Pabst et al, 1998;Rothkötter et al, 1991). In contrast, AGP avoid bacterial overgrowing and reduce the bacterial immune stimulation at an intestine level.…”

Section: Discussionmentioning

confidence: 96%

Use of yeast cell walls; β-1, 3/1, 6-glucans; and mannoproteins in broiler chicken diets

Morales-López

Auclair

García³

et al. 2009

Poultry Science

109

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Two experiments were carried out to evaluate the effect of dietary addition of yeast cell wall (YCW); beta-1, 3/1, 6-glucan (BG); and mannoprotein complex (MP) purified fractions in broilers. In experiment 1, there was a control diet and 5 experimental diets containing, respectively: 10 mg of avilamycin (AVI)/kg of feed, 500 mg of YCW/kg of feed, 95 mg of MP/kg of feed, 145 mg of BG/kg of feed, and 95 mg of MP plus 145 mg of BG/kg of feed. All birds were vaccinated via drinking water against Newcastle disease virus at 9 d of age. At 42 d, chickens fed AVI, YCW, MP + BG, and BG diets had similar BW not significantly different from chickens fed the control diet. The antibody response of Newcastle disease virus vaccine was not affected by any experimental treatment. Broilers fed MP + BG diet had greater thymus weights (P

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Section: Discussionmentioning

confidence: 96%

Use of yeast cell walls; β-1, 3/1, 6-glucans; and mannoproteins in broiler chicken diets

Morales-López

Auclair

García³

et al. 2009

Poultry Science

109

View full text Add to dashboard Cite

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The Specific Anti-Parasite Immune Responses of Germ-Free and Conventional Rats Infected with Trypanosoma lewisi

Ms¹

1987

The Journal of Parasitology

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To test the hypothesis that the rapid immune response of rats to Trypanosoma lewisi is elicited by prior exposure to cross-reacting environmental antigens, the early immune response to infection with this nonpathogenic protozoan was studied in germ-free and conventional rats. In germ-free rats, initial levels of both IgG and IgM were significantly lower than those of conventional rats. After infection, the germ-free rats made more immunoglobulins of both classes, and made them more quickly, than did conventional rats. Trypanosome-specific antibodies appeared earlier and in higher titers in the germ-free rats. Because they lacked intestinal microflora, it is unlikely that the germ-free rats' responses had been primed; thus, these observations indicated that the conventional rats' responses to some trypanosome antigens had been down-regulated by their prior exposure to environmental antigens. However, protective antibodies that inhibited parasite reproduction (ablastin) may have been primed, because these appeared in sera 2 days earlier in conventional rats. Despite much lower rates of production of trypanosome-specific antibodies, the conventional rats had the same peak parasitemias and times to crisis as germ-free rats. Thus it is apparent that protective immunity to this nonpathogenic parasite is not down-regulated by prior exposure to environmental antigens, as would be predicted.

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Host Defense Mechanisms in Gnotobiotic Animals

Cited by 2 publications

References 152 publications

Use of yeast cell walls; β-1, 3/1, 6-glucans; and mannoproteins in broiler chicken diets

Use of yeast cell walls; β-1, 3/1, 6-glucans; and mannoproteins in broiler chicken diets

The Specific Anti-Parasite Immune Responses of Germ-Free and Conventional Rats Infected with Trypanosoma lewisi

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