Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway

Zhang, Yihan; Sun, Changning; Xiao, Guokai; Gu, Yuchao

doi:10.1016/j.bbrc.2019.03.029

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…As reported, mitochondria are central regulators of neurons, which are damaged as key factors underlying cognitive defects in neurodegenerative diseases [ 28 ]. Bax is a proapoptotic factor and Bcl-2 is an antiapoptotic factor, which localizes on the mitochondrial surface, play an important role in the process of apoptosis [ 29 , 30 ]. Following overexpression of Bax, it moves from the cytosol to the outer mitochondrial membrane and forms homo-oligomeric complexes with Bax, resulting in the changes in the permeability of the mitochondrial outer membrane.…”

Section: Discussionmentioning

confidence: 99%

Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway

Xie

Zhou

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Huang-Pu-Tong-Qiao formula (HPTQ), a traditional Chinese medicine (TCM) formula used to improve cognitive impairment. However, the underlying neuroprotective mechanism of HPTQ treated for diabetic cognitive dysfunction (DCD) remains unclear. The purpose of this study was to investigate the neuroprotective mechanism of HPTQ in DCD mice based on molecular docking. Methods. To investigate the neuroprotective effect of HPTQ in DCD, the Morris water maze (MWM), novel object recognition (NOR) test was used to detect the learning and memory changes of mice; hematoxylin-eosin (HE) staining was used to investigate the damage of hippocampal neurons; the western blot (WB) was used to examine the level of brain-derived neurotrophic factor (BDNF) of hippocampus. To investigate the neuroprotective mechanism of HPTQ in DCD, molecular docking was used to predict the possible target proteins of different active components in HPTQ and then the WB was used to verify the expression of key target proteins in the hippocampus of mice. Results. HPTQ improved the learning and memory ability, hippocampal neuron damage, and the level of BDNF in the hippocampus of the DCD model treated with HFD/STZ for 12 weeks. Besides, the results of molecular docking showed that the main chemical components of HPTQ could be well combined with the targets of Bcl-2-associated X (Bax) and B-cell lymphoma2 (Bcl-2) and caspase-3. The levels of Bax/Bcl-2 protein ratio and caspase-3 increased in the DCD model while the HPTQ inhibited it. In addition, HPTQ restored DCD-induced decline of p-CREB, BDNF, TrkB, and p-Akt in the hippocampus. Conclusions. These data indicated that HPTQ ameliorates the hippocampus apoptosis in diabetic cognitive dysfunction mice by activating CREB/BDNF/TrkB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway

Xie

Zhou

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Aurein 1.2 is a peptide found in the frog Litoria aurea , which was reported to exhibit high activity against 55 different cancer cell lines in vitro ( Rozek et al, 2000 ; Dennison et al, 2007 ). Furthermore, hymenochirin-1B is a cationic α-helix peptide belonging to the hymenochirin family from the frog Hymenochirus boettgeri , and has been reported to exert antineoplastic activities against lung cancer cells NCI-H1299 and A549 by inducing apoptosis and cell cycle arrest through the mitochondrial pathway ( Zhang et al, 2019 ). Additionally, many other ACPs from amphibians and their mechanisms of action are summarized in Table 2 .…”

Section: Animal Sources Of Amps With Anticancer Activitymentioning

confidence: 99%

Anticancer activities of natural antimicrobial peptides from animals

Qu,

Yuan,

Liu

et al. 2024

Front. Microbiol.

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Cancer is the most common cause of human death worldwide, posing a serious threat to human health and having a negative impact on the economy. In the past few decades, significant progress has been made in anticancer therapies, but traditional anticancer therapies, including radiation therapy, surgery, chemotherapy, molecular targeted therapy, immunotherapy and antibody-drug conjugates (ADCs), have serious side effects, low specificity, and the emergence of drug resistance. Therefore, there is an urgent need to develop new treatment methods to improve efficacy and reduce side effects. Antimicrobial peptides (AMPs) exist in the innate immune system of various organisms. As the most promising alternatives to traditional drugs for treating cancers, some AMPs also have been proven to possess anticancer activities, which are defined as anticancer peptides (ACPs). These peptides have the advantages of being able to specifically target cancer cells and have less toxicity to normal tissues. More and more studies have found that marine and terrestrial animals contain a large amount of ACPs. In this article, we introduced the animal derived AMPs with anti-cancer activity, and summarized the types of tumor cells inhibited by ACPs, the mechanisms by which they exert anti-tumor effects and clinical applications of ACPs.

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“…Increase in the cationicity of hymenochirin-1B while reducing helicity by substitutions with D-lysine, generated analogues with more potent cytotoxic activity against MDA-MB-231 than the native peptide, further accompanied by substantial hemolytic effects (46). Zhang et al have shown that hymenochirin-1B decreases mitochondrial membrane potential and increases the level of ROS and the expression of apoptosis associated proteins (Bax/Bcl-2 ratio and activated caspase-3) in lung cancer cell lines (47).…”

Section: Amphibian Hdpsmentioning

confidence: 99%

Overview of Host Defense Peptides with Promising Anti-Breast Cancer Activity

Zornić

Lukovic²,

Jevtović

et al. 2022

Serbian Journal of Experimental and Clinical Research

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Breast cancer is the leading cause of death among women worldwide. The main limitations of conventional anti-cancer therapy, including breast cancer treatment, are side effects and the development of resistance to chemotherapeutics. Host defense peptides (HDPs) are bioactive compounds of innate immunity isolated from almost all living organisms, which exhibit wide range of biological activities. This review focuses on the anti-cancer effects of HDPs and their therapeutic potential against breast cancer. Numerous HDPs from different sources, including mammalian and amphibian origin, and their chemically modified analogues, exert the spectrum of anti-cancer activities. These effects include direct disruption of cancer cell membrane, induction of apoptosis, inhibition of angiogenesis and cancer cell proliferation, but also the modulation of anti-cancer immune response. Selected examples of HDPs of different origin and their anti-breast cancer capacities have been reviewed. Conclusively, due to their anti-cancer effects accompanied by substantial selectivity for cancer cells and low toxicity for normal cells, HDPs have been widely recognized as possible therapeutic agents.

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Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway

Cited by 12 publications

References 22 publications

Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway

Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway

Anticancer activities of natural antimicrobial peptides from animals

Overview of Host Defense Peptides with Promising Anti-Breast Cancer Activity

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