Host-Dependent Patterns of Tissue Injury in Invasive Pulmonary Aspergillosis

Stergiopoulou, Theodouli; Meletiadis, Joseph; Roilides, Emmanuel; Kleiner, David E.; Schaufele, Robert L.; Roden, Maureen; Harrington, Susan M.; Dad, Luqman; Segal, Brahm H.; Walsh, Thomas

doi:10.1309/g422-5v1p-2052-3h64

Cited by 19 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with GVHD post-HSCT who are receiving high dose corticosteroids are also at risk for deeply invasive fusariosis and other mycoses, possibly in relation to the functional neutropenia observed in this setting. 48 The epidemiology of invasive fusariosis is best described in patients with acute leukemia/myelodysplastic syndrome (MDS) and HSCT recipients where the 12-month cumulative incidence is 0.1 to 0.6%. [49][50][51] Fusarium infection most often occurs during induction chemotherapy; 52 whereas, the median time from HSCT to onset of infection is 123 days in the U.S.…”

Section: Clinical Epidemiologymentioning

confidence: 99%

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

Jacobs

Wengenack

Walsh

2020

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Hyaline molds, widely distributed in nature, are an important and increasing cause of invasive fungal infections in humans, likely due to an expanding population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics. Sinopulmonary disease and disseminated infection are common manifestations in neutropenic patients and transplant recipients, whereas, catheter-related and localized soft tissue infections predominate in immunocompetent hosts. These organisms are not reliably differentiated based on their morphology in tissue; rather, efforts should be made to establish a microbiologic diagnosis via culture or molecular-based methods to guide antifungal management and inform prognosis. Herein, we review the epidemiology, clinical manifestations, diagnosis, and management of these opportunistic pathogens known to cause hyalohyphomycoses: Scedosporium spp., Lomentospora prolificans, Fusarium spp., Scopulariopsis spp., Arthrographis kalrae, Trichoderma spp., Acremonium spp., Paecilomyces variotii, Purpureocillium lilacinum, and Penicillium species.

show abstract

Section: Clinical Epidemiologymentioning

confidence: 99%

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

Jacobs

Wengenack

Walsh

2020

Semin Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…8.105C) may be present. 90 Angioinvasion is identified microscopically and may be enhanced with silver and elastic stains (Fig. 8.106A and B).…”

Section: Other Hyphate Fungimentioning

confidence: 99%

“…Aspergillus terreus is an opportunistic fungus that infects patients with chronic granulomatous disease, as well as other immunocompromised hosts. 90 Its hyphae…”

Section: Other Hyphate Fungimentioning

confidence: 99%

Pathology of Pulmonary Infection

Kradin¹,

Mark²

2018

Diagnostic Pathology of Infectious Disease

View full text Add to dashboard Cite

“…Anaphylactic and septic shock are characterised from the outset by such vasodilatation, which is caused by a variety of mediators that are released from inflammatory and other cells. 71 The identification of the same mediators in experimental hypovolaemia 72 suggests that the pathogenesis of shock may be similar regardless of the cause.…”

Section: X-irradiationmentioning

confidence: 99%