Host-derived biomarkers in gingival crevicular fluid for complementary diagnosis of apical periodontitis

Garrido, Mauricio; Dezerega, Andrea; Castro-Martínez, Alfredo; Hernández, Marcela

doi:10.5321/wjs.v3.i2.19

Cited by 7 publications

(7 citation statements)

References 50 publications

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“…In agreement with our results, broad evidence supports high levels of MMP-8, MMP-9, MMP-2, MPO, IL-1b, IL-6 and RANKL/OPG and reduced levels of PTN in CP patient's GCF (Mantyla et al 2006, Marcaccini et al 2010, Reinhardt et al 2010, Sorsa et al 2010, Buduneli & Kinane 2011, Balli et al 2014; whereas limited evidence reports higher gelatinolytic activity of MMP-2 and -9, and levels of MMP-8 and TNF-a in GCF from AP patients (Belmar et al 2008, Burgener et al 2010, Garrido Flores et al 2011, Garrido et al 2014). On the other hand, Dkk-1 and soluble TRAP-5 were determined for the first time in GCF.…”

Section: Discussionsupporting

confidence: 70%

Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study

Baeza

Garrido

Hernández-Ríos

et al. 2016

J Clinic Periodontology

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110

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Section: Discussionsupporting

confidence: 70%

Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study

Baeza

Garrido

Hernández-Ríos

et al. 2016

J Clinic Periodontology

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110

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“…5 The hallmark of AAP is the destruction of periradicular periodontal tissues leading to the formation of an osteolytic apical lesion in the absence of clinical symptoms. 2 Few earlier studies including GCF analysis have been conducted in AAP, but the results are consistent with these findings. Higher levels of pro-MMP-9 were reported for the first time in teeth with apical lesions and healthy contra lateral controls in a split mouth design.…”

Section: Mmps As Diagnostic Biomarkers Of Periodontal/peri-implant DIsupporting

confidence: 70%

“…Periodontal diseases are chronic infections that affect the gingiva (gingivitis) and the supporting tissues of the teeth, namely, the alveolar bone, periodontal ligament, and radicular cementum in periodontitis. [1][2][3][4] The later can either affect the marginal periodontium (ie, chronic periodontitis) or the apical periradicular tissues, known as apical periodontitis. 5 They can be considered a global health problem that can lead to tooth loss, widespread oral health dysfunction, and increased susceptibility to other systemic diseases, such as cardiovascular diseases and stroke, diabetes, preterm delivery of low-birth-weight babies, arthritis, and lung inflammation.…”

Section: Introductionmentioning

confidence: 99%

Oral fluid matrix metalloproteinase (MMP)-8 as a diagnostic tool in chronic periodontitis

Hernández-Ríos¹,

Hernández²,

Garrido³

et al. 2016

MNM

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Periodontal diseases that affect the marginal and apical periodontium result from the interaction between bacterial biofilm and the host response. Oral fluid biomarkers might aid clinical diagnosis. Matrix metalloproteinases (MMPs) are a family of 24 proteases that act in physiological and pathological conditions. They can degrade almost all extracellular matrix constituents and regulate inflammatory processes. They are mainly inhibited by tissue inhibitors of metalloproteinases. The aim of this study was to perform a current literature review with a special reference on the diagnostic and clinical utility of oral fluid MMPs, especially MMP-8, and their inhibitors in periodontal and oral diseases. MMP-8 is the main collagenolytic MMP detected in oral fluids, such as saliva, oral mouthrinse, gingival crevicular fluid, and peri-implant fluid. MMP-8, and potentially MMP-9, in oral fluids represent strong biomarker candidates associated especially with periodontal disease diagnosis, severity, progression, and follow-up. Additionally, they show diagnostic potential for systemic conditions, such as pregnancy, myocardial infarction, and smoking. A commercially available mouthrinse, active MMP-8 chair-side/ point-of-care lateral flow immunoassay, shows enough sensitivity and specificity to detect clinical signs of periodontitis. The current literature supports that high MMP-8 levels reflect the loss of periodontal supporting tissues rather than inflammation, representing a potentially useful sidediagnostic point-of-care oral disease biomarker, especially in periodontal diseases.

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“…The possible correlation between CHD and CAP is emerging clearly at microbiological, clinical, inflammatory, as well as molecular levels 35, 36, 37. More recently, Berlin-Broner Y et al.…”

Section: Conclusion/future Directionsmentioning

confidence: 99%

Lesions of endodontic origin: An emerging risk factor for coronary heart diseases

Bains

2018

Indian Heart Journal

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A high inflammatory state, such as atherosclerosis, is a major underlying cause of coronary heart diseases (CHDs). Inflammatory mediators are known to lead to endothelial dysfunction and play a key role in initiation, progression, and rupture of atherothrombotic plaque. Chronic inflammatory dental infections such as periodontitis and lesions of endodontic origin or chronic apical periodontitis (CAP) may provide an environment conducive for such events. Atherosclerosis has shown to share a common spectrum of inflammatory markers with apical periodontitis. The possible correlation between CHD and CAP is emerging at microbiological, clinical, inflammatory, and molecular levels. This less recognized fact should be discussed more among the dental and medical fraternity so that more awareness and positive approach toward oral health can be created among patients and health-care providers.

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Host-derived biomarkers in gingival crevicular fluid for complementary diagnosis of apical periodontitis

Cited by 7 publications

References 50 publications

Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study

Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study

Oral fluid matrix metalloproteinase (MMP)-8 as a diagnostic tool in chronic periodontitis

Lesions of endodontic origin: An emerging risk factor for coronary heart diseases

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