2024
DOI: 10.21203/rs.3.rs-3870666/v1
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Host DNA depletion assisted metagenomic sequencing of bronchoalveolar lavage fluids for diagnosis of pulmonary tuberculosis

Jinfeng Yuan,
LiPing Ma,
Juan Du
et al.

Abstract: [Background]Metagenomic next-generation sequencing (mNGS) has greatly improved our understanding of pathogens in infectious diseases such as pulmonary tuberculosis (PTB). However, high human DNA background (> 95%) impedes the detection sensitivity of mNGS in identifying intracellular Mycobacterium tuberculosis (MTB), posing a pressing challenge for MTB diagnosis. Therefore, there is an urgent need to improve MTB diagnosis performance in PTB patients. [Methods]In this study, we optimized mNGS method for diag… Show more

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