2024
DOI: 10.1101/2024.03.13.583595
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Host evolution improves genetic circuit function in complex growth environments

Joanna T. Zhang,
Andrew Lezia,
Philip Emmanuele
et al.

Abstract: Genetically engineered bacteria have become an attractive platform for numerous biomedical and industrial applications. Despite genetic circuitry functioning predictably under favorable growth conditions in the lab, the same cannot be said when placed in more complex environments for eventual deployment. Here, we used a combination of evolutionary and rational engineering approaches to enhanceE. colifor robust genetic circuit behavior in non-traditional growth environments. We utilized adaptive laboratory evol… Show more

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