Host factors affecting oral candidiasis

Wyk, Candice Van; Steenkamp, Vanessa

doi:10.1080/10158782.2011.11441414

Cited by 20 publications

(30 citation statements)

References 45 publications

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“…brackets, archwires, elastomers), which can become of pathogens reservoir and with predisposing factors contributed to candidosis. Candida infection is the most common oral mucosa disease, especially in immunodeficiency patients (4,5).…”

Section: Introductionmentioning

confidence: 99%

Candida prevalence and oral hygiene due to orthodontic therapy with conventional brackets

Grzegocka

Krzyściak

Talaga-Ćwiertnia

et al. 2020

Preprint

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Background Conventional brackets are often used during orthodontic therapy patients with malocclusion. Nevertheless, their complicated construction greatly inhibits oral hygiene, which predisposes to the increased carriage of the microbiota. It seems that orthodontic brackets could be a reservoir of yeast and predisposing to develop oral candidosis. Objectives The aim of this study was to assess changes in Candida species prevalence and periodontal parameters after orthodontic brackets placement in patients who received oral hygiene instruction; to determine role of elastic ligatures in those changes; to characterize isolated yeasts according to their ability to biofilm formation. Patients/Methods 17 participants (average age 17±7 years) have been monitored by taking oral rinses, elastomeric ligatures samples and evaluation of API and GBI Indexes before and after placement of orthodontic conventional brackets for 12 weeks. Isolated yeasts was counted and used to the biofilm formation assay. Results 116 samples (67 oral rinses and 49 orthodontic elastomers) were collected. 51% of patients were carriers of Candida in which C. albicans was the most common species. The average number of colonies (CFU/ml) obtained from oral rinses showed an upward trend depending on duration of the study and some correlation with periodontal indexes (API, GBI) was found. One third of the analysed strains have shown ability to form greater biofilm than control strain. Conclusions Orthodontic ligatures surface permit biofilms creation and orthodontic brackets change dynamic oral microbiota. Maintaining proper oral hygiene is crucial for every orthodontic patient.

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Section: Introductionmentioning

confidence: 99%

Candida prevalence and oral hygiene due to orthodontic therapy with conventional brackets

Grzegocka

Krzyściak

Talaga-Ćwiertnia

et al. 2020

Preprint

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“…The opportunistic characteristic of Candida species allows the transition from harmless to a pathogenic microorganism and is responsible for a wide range of systemic and superficial infections in the immunocompromised hosts [6]. A number of virulence factors such as adhesion, hydrolytic enzyme production for example, proteinases and phospholipases, hyphal formation, and phenotypic switching may be involved to establish an infective process.…”

Section: Introductionmentioning

confidence: 99%

Effect ofPiper betleandBrucea javanicaon the Differential Expression of Hyphal Wall Protein (HWP1) in Non-Candida albicans Candida(NCAC) Species

Harun

Jamil

Jamaludin

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The study aimed to identify the HWP1 gene in non-Candida albicans Candida species and the differential expression of HWP1 following treatment with Piper betle and Brucea javanica aqueous extracts. All candidal suspensions were standardized to 1 × 106 cells/mL. The suspension was incubated overnight at 37 °C (C. parapsilosis, 35°C). Candidal cells were treated with each respective extract at 1, 3, and 6 mg/mL for 24 h. The total RNA was extracted and reverse transcription-polymerase chain reaction was carried out with a specific primer of HWP1. HWP1 mRNAs were only detected in C. albicans, C. parapsilosis, and C. tropicalis. Exposing the cells to the aqueous extracts has affected the expression of HWP1 transcripts. C. albicans, C. parapsilosis, and C. tropicalis have demonstrated different intensity of mRNA. Compared to P. betle, B. javanica demonstrated a higher suppression on the transcript levels of HWP1 in all samples. HWP1 was not detected in C. albicans following the treatment of B. javanica at 1 mg/mL. In contrast, C. parapsilosis and C. tropicalis were shown to have HWP1 regulation. However, the expression levels were reduced upon the addition of higher concentration of B. javanica extract. P. betle and B. javanica have potential to be developed as oral health product.

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“…Even though Candida is a part of the normal oral microbiota found in 17 -75% human population, it can often be the cause of oral mycoses, especially in immunode ciency patients (8,9). The most common etiological factor of oral candidosis is Candida albicans.…”

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confidence: 99%

“…C. tropicalis, C. glabrata, C. parapsilosis, C. krusei sometimes occur with high prevalence, especially in susceptible patients such as diabetic (10)(11)(12). All these species have the great ability to form bio lm, especially with oral Gram + bacteria (8)(9)(10)(11).…”

mentioning

confidence: 99%

Candida prevalence and oral hygiene due to orthodontic therapy with conventional brackets

Grzegocka

Krzyściak

Hille-Padalis

et al. 2020

Preprint

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Background: Conventional brackets are often used during orthodontic therapy of patients with malocclusion. T heir complicated construction greatly inhibits oral hygiene, which predisposes to increased carriage of microbiota. Orthodontic brackets could be a reservoir of yeast and predispose to oral candidosis.Objectives: The aim of this study was to assess Candida prevalence and role of oral hygiene during fixed appliance therapy. Further aim was to characterize isolated yeasts according to their ability to biofilm formation.Methods: Seventeen participants (average age 17 ± 7 years) were monitored by taking oral rinses, elastomeric ligatures samples and evaluation of Approximal Plaque Index (API) and Gingival Bleeding Index (GBI) before and after placement of orthodontic conventional brackets for 12 weeks. Isolated yeasts w ere counted and biofilm formation was evaluated.Results: One hundred and sixteen samples (67 oral rinses and 49 orthodontic elastomers) were collected. Ten patients (58.8% subjects) were Candida-carriers (2 were colonized after bracket placement) and C. albicans was the most common species. The average number of yeasts in the oral cavity showed some fluctuation during the study but in general with an upward trend (adj. R2 = 0.7967, p = 0.07025). The correlation of median number of yeasts with periodontal indexes (API, GBI) was found. I n Candida-carries average API values decreased (adj. R 2 = 0.95; p = 0.01709), while in non- Candida -carriers average GBI values increased (adj. R 2 = 0.92; p = 0.0256).Conclusions: Treatment with orthodontic appliances promotes Candida yeast colonization which is variable over time in terms of strain and species, with domination of C. albicans, without an increased biofilm-forming activity. In carriers, the API value decreases over time, and in non-colonized patients the GBI value increases – which may have a predictive significance for the development of oral candidiasis during orthodontic treatment.

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Host factors affecting oral candidiasis

Cited by 20 publications

References 45 publications

Candida prevalence and oral hygiene due to orthodontic therapy with conventional brackets

Candida prevalence and oral hygiene due to orthodontic therapy with conventional brackets

Effect ofPiper betleandBrucea javanicaon the Differential Expression of Hyphal Wall Protein (HWP1) in Non-Candida albicans Candida(NCAC) Species

Candida prevalence and oral hygiene due to orthodontic therapy with conventional brackets

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