Host Factors Involved in the Intracellular Movement of Bamboo mosaic virus

Abstract

Viruses move intracellularly to their replication compartments, and the newly synthesized viral complexes are transported to neighboring cells through hijacking of the host endomembrane systems. During these processes, numerous interactions occur among viral proteins, host proteins, and the cytoskeleton system. This review mainly focuses on the plant endomembrane network, which may be utilized by Bamboo mosaic virus (BaMV) to move to its replication compartment, and summarizes the host factors that may be directly involved in delivering BaMV cargoes during intracellular movement. Accumulating evidence indicates that plant endomembrane systems are highly similar but exhibit significant variations from those of other eukaryotic cells. Several Nicotiana benthamiana host proteins have recently been identified to participate in the intracellular movement of BaMV. Chloroplast phosphoglycerate kinase, a host protein transported to chloroplasts, binds to BaMV RNAs and facilitates BaMV replication. NbRABG3f is a small GTPase that plays an essential role in vesicle transportation and is also involved in BaMV replication. These two host proteins may deliver BaMV to the replication compartment. Rab GTPase activation protein 1, which switches Rab GTPase to the inactive conformation, participates in the cell-to-cell movement of BaMV, possibly by trafficking BaMV cargo to neighboring cells after replication. By analyzing the host factors involved in the intracellular movement of BaMV and the current knowledge of plant endomembrane systems, a tentative model for BaMV transport to its replication site within plant cells is proposed.

The Coat Protein of Citrus Yellow Vein Clearing Virus Interacts with Viral Movement Proteins and Serves as an RNA Silencing Suppressor

“…Additionally, the protein well-localized at the PD. Many plant RNA viruses and their movement proteins are associated with the ER network of their hosts, and the plant ER is involved in plant virus movement and viral replication complex formation [3,41,57,58,59,60]. The TGB proteins of some plant viruses were also found to target the plasmodesmata by association with the ER [4,26,48].…”

A Concise Review of Dendrocalamus asper and Related Bamboos: Germplasm Conservation, Propagation and Molecular Biology

“…Recent reports have emerged of etic recombination events in Indonesia [85], which indicate Taiwan as the origin of the virus. Molecular data has provided evidence of the factors involved in the intracellular movement of the virus, which is mediated by movement proteins [86], and measurements for the containment and eradication of the BaMV have included treatments with abscisic acid [87], which has been reported to induce resistance and improve the host defense, as well as the application of interfering satellite RNA [88] in transgenic bamboo plants. The adoption of pertinent biosecurity measures during import of the germplasm, as well as the monitoring of invasive pathogens in commercial plantations, is currently the best available measure for the control of BaMV and other pathogens.…”

Disrupting the Homeostasis of High Mobility Group Protein Promotes the Systemic Movement of Bamboo mosaic virus

“…Host Factors Required for BaMV Systemic Movement Are Regulated in NbHMG1/2a-Silenced and -Overexpressing Plants Several host factors required for BaMV cell-to-cell and systemic movement have been identified previously (Cheng, 2017;Huang et al, 2017a). These factors include the activating protein Rab GTPase (Rab-GAP1) (Huang et al, 2013), casein kinase 2α (CK2α) (Hung et al, 2014), serine/threonine kinase-like protein (STKL) (Cheng et al, 2013), and thioredoxin h protein (TRXh2) (Chen et al, 2018).…”