Host genetic background and the innate inflammatory response of lung to influenza virus

Trammell, Rita A; Liberati, Teresa A.; Toth, Linda A

doi:10.1016/j.micinf.2011.08.008

Cited by 40 publications

(40 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DBA/2 mice have been found to be susceptible to lung infections which include influenza (Trammell et al, 2012), Mycobacterium tuberculosis (Cardona et al, 2003), Pseudomonas aeruginosa (Gosselin et al, 1995), and Bacillus anthracis (Yadav et al, 2011). In models of hypersensitivity pneumonitis, C57Bl/ 6 mice are sensitive to lung disease while DBA/2 are resistant, and differential cytokine expression (chiefly IL-12) is shown to be the determining factor (Gudmundsson et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Genetic susceptibility to toxicologic lung responses among inbred mouse strains following exposure to carbon nanotubes and profiling of underlying gene networks

Frank

Carreira

Shanmukhappa

et al. 2017

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

The risk of human exposure to fiber nanoparticles has risen in recent years due to increases in the manufacture and utilization of carbon nanotubes (CNTs). CNTs are present as airborne particulates in occupational settings and their hazard potential has been demonstrated in experimental lung exposure studies using inbred mouse strains. However, it is not known whether different inbred strains differ in lung responses to CNTs by virtue of their genetics. In this work, common inbred strains (BALB/c, C57Bl/6, DBA/2, and C3H/ He) were exposed to CNTs via oropharyngeal aspiration and lung histology and bronchoalveolar lavage (BAL) samples were evaluated over 28 days with the objective of evaluating sensitivity/resistance among strains. C57Bl/6 mice developed significantly mo re extensive type II pneumocyte (T2P) hyperplasia and alveolar infiltrate compared to DBA/2 mice, which were resistant. Surprisingly, DBA/2 but not C57Bl/ 6 mice were extremely sensitive to increases in leukocytes recovered in BAL fluid. Underlying global gene expression patterns in the two strains were compared using mRNA sequencing to investigate regulatory networks associated with the different effects. The impact of exposure on gene networks regulating various aspects of immune response and cell survival was limited in DBA/2 mice compared to C57Bl/6. Investigation of B6D2F1 (C57Bl/6 x DBA/2 hybrid) mice demonstrated inheritance of sensitivity to CNT exposures in regard to toxicologic lung pathology and BAL leukocyte accumulations. These findings demonstrate genetic bases of susceptibility to CNT particle exposures and both inform the use of inbred mouse models and suggest the likelihood of differences in genetic susceptibility among humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic susceptibility to toxicologic lung responses among inbred mouse strains following exposure to carbon nanotubes and profiling of underlying gene networks

Frank

Carreira

Shanmukhappa

et al. 2017

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

show abstract

“…116 Neither strain might be as suitable as DBA/2J mice, which have a more intense inflammatory response to influenza virus infection. [117][118][119] Investigators should also consider testing immunomodulatory agents in mice that have the same highrisk conditions as humans; e.g., pregnancy, 62 obesity 120 and cardiovascular disease. 121 Once the most promising immunomodulatory agent (or combination of agents) has been identified, it should then be studied in ferrets and, if necessary, in non-human primates.…”

Section: Acknowledgmentsmentioning

confidence: 99%

The controversy over H5N1 transmissibility research

Fedson¹,

Opal

2013

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

“…For example, intranasal inoculation with the influenza virus in mice results in increases in non-rapid eye movement sleep (NREM) and decreases in rapid eye movement sleep (REM), though body temperature is decreased (Fang, Sanborn et al 1995; Toth, Rehg et al 1995; Fang, Tooley et al 1996; Toth and Williams 1999; Toth and Opp 2001). Genetics play a role in the susceptibility and resistance to infectious agents (Cooke and Hill 2001; Hill 2001; De Maio, Torres et al 2005; Tuite and Gros 2006; Trammell and Toth 2008; Trammell, Liberati et al 2012); e.g., the increases in NREM with influenza appear to be strain dependent because C57BL/6 (B6) mice display increases whereas BALB/c mice do not (Toth, Rehg et al 1995). …”

Section: Introductionmentioning

confidence: 99%

Sleep and behavior during vesicular stomatitis virus induced encephalitis in BALB/cJ and C57BL/6J mice

Machida

Ambrozewicz

Breving

et al. 2014

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Intranasal application of vesicular stomatitis virus (VSV) produces a well-characterized model of viral encephalitis in mice. Within one day post-infection (PI), VSV travels to the olfactory bulb and, over the course of 7 days, it infects regions and tracts extending into the brainstem followed by clearance and recovery in most mice by PI day 14 (PI 14). Infectious diseases are commonly accompanied by excessive sleepiness; thus, sleep is considered a component of the acute phase response to infection. In this project, we studied the relationship between sleep and VSV infection using C57BL/6 (B6) and BALB/c mice. Mice were implanted with transmitters for recording EEG, activity and temperature by telemetry. After uninterrupted baseline recordings were collected for 2 days, each animal was infected intranasally with a single low dose of VSV (5 × 104 PFU). Sleep was recorded for 15 consecutive days and analyzed on PI 0, 1, 3, 5, 7, 10, and 14. Compared to baseline, amounts of non-rapid eye movement sleep (NREM) were increased in B6 mice during the dark period of PI 1–5, whereas rapid eye movement sleep (REM) was significantly reduced during the light periods of PI 0–14. In contrast, BALB/c mice showed significantly fewer changes in NREM and REM. These data demonstrate sleep architecture is differentially altered in these mouse strains and suggests that, in B6 mice, VSV can alter sleep before virus progresses into brain regions that control sleep.

show abstract

Host genetic background and the innate inflammatory response of lung to influenza virus

Cited by 40 publications

References 27 publications

Genetic susceptibility to toxicologic lung responses among inbred mouse strains following exposure to carbon nanotubes and profiling of underlying gene networks

Genetic susceptibility to toxicologic lung responses among inbred mouse strains following exposure to carbon nanotubes and profiling of underlying gene networks

The controversy over H5N1 transmissibility research

Sleep and behavior during vesicular stomatitis virus induced encephalitis in BALB/cJ and C57BL/6J mice

Contact Info

Product

Resources

About