2016
DOI: 10.1039/c6cc03643k
|View full text |Cite
|
Sign up to set email alerts
|

Host–guest binding motifs based on hyperbranched polymers

Abstract: Host-guest chemistry involves the binding of a substrate molecule (guest) to a receptor molecule (host). Various molecules, including crown ethers, cryptands, cyclophanes, calixarenes, cyclodextrins, and so on, have been used as molecular hosts. However, only limited small molecules or simple ions can be encapsulated in these hosts. Fortunately, as a class of unique host molecules, hyperbranched polymers (HBPs) can bind to numerous guests through topological entrapment, electrostatic bonding, hydrogen bonding … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
9
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
9

Relationship

2
7

Authors

Journals

citations
Cited by 17 publications
(9 citation statements)
references
References 136 publications
0
9
0
Order By: Relevance
“…The delivery and release of drugs, in either formulations or bodies, usually occur in an aqueous environment, where the hydrophobic domain on the drug structure can act as a good guest candidate for host–guest recognition in a drug-loading procedure [ 81 , 82 ]. A typical guest drug has a highly hydrophobic structure, which acts as a proton-donating agent to form multiple hydrogen bonds with the proton-accepting structure of the host molecules [ 83 ].…”
Section: Supramolecular Interaction-mediated Drug Loadingmentioning
confidence: 99%
“…The delivery and release of drugs, in either formulations or bodies, usually occur in an aqueous environment, where the hydrophobic domain on the drug structure can act as a good guest candidate for host–guest recognition in a drug-loading procedure [ 81 , 82 ]. A typical guest drug has a highly hydrophobic structure, which acts as a proton-donating agent to form multiple hydrogen bonds with the proton-accepting structure of the host molecules [ 83 ].…”
Section: Supramolecular Interaction-mediated Drug Loadingmentioning
confidence: 99%
“…The special structure endows itself a good candidate as a host for the formation of inclusion complexes with some hydrophobic guest molecules in aqueous media (for example, cholic acids (CA), adamantane derivatives, and AIE molecules of tetraphenylethylene (TPE) and so on). [15][16][17][18][19][20][21][22][23] The formation of host-guest complex with CDs could alter the hydrophobic molecules more soluble in water and further weaken the aggregated state, [24][25][26][27][28] which was applied to tune the aggregated state and fluorescence of AIE molecule. For example, Tang et al designed a 𝛾-cyclodextrin (𝛾-CD)-TPE hostguest inclusion complex, resulting in the disaggregation of TPE and no fluorescence in water.…”
Section: Introductionmentioning
confidence: 99%
“…The reversible process of assembly and disassembly through host–guest interactions , has emerged as a powerful and flexible strategy to assemble supramolecular structures and attracted interest in optical sensing and imaging, drug and gene delivery, and so on. ,, Cyclodextrins (CDs), a class of cyclic oligosaccharides, are extensively employed as host building blocks owing to their hydrophobic cavities and hydrophilic exteriors, facilitating the formation of inclusion complexes with some hydrophobic guest molecules (for example, adamantine derivatives) in aqueous media . Therefore, the hydrophobic molecules could become more hydrophilic or disperse once the host–guest complexes with CDs in aqueous solutions are formed, which may be used to tune the aggregation and fluorescence of AIE molecules. , For example, Tang et al engineered a γ-CD-TPE host–guest inclusion complex, resulting in the disaggregation of TPE and no fluorescence in water .…”
Section: Introductionmentioning
confidence: 99%