Host–Guest Inclusion Complexation of α-Cyclodextrin and Triiodide Examined Using UV–Vis Spectrophotometry

Pursell, Janet L.; Pursell, Christopher J.

doi:10.1021/acs.jpca.6b00982

Cited by 52 publications

(47 citation statements)

References 27 publications

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“…It should be noted that indications for the affinity of anions to hydrophobic binding sites existed early in the literature81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103 but were in part attributed to a putative hydrophobic (or lipophilic) property of large anions, implying the hydrophobic effect as driving force. The hydrophobic and chaotropic effect can and need to be conceptually distinguished for the reason stated above and also because the hydrophobic nature of a solute is subject to a conventional definition, which chaotropic ions do not fulfill.…”

Section: Thermochemical Hydration Characteristicsmentioning

confidence: 99%

“…Despite the hydrophobic nature of these cavities, early indications for the competitive binding of ions exist 96, 99, 130. Taraszewska and Wójcik were the first to correlate the small but significant binding of simple anions to α‐CD and β‐CD with the Hofmeister character of the anions 99.…”

Section: Examplesmentioning

confidence: 99%

“…Macrocyclic hosts are popular in supramolecular chemistry because they possess hydrophobic cavities that mimic biological binding sites,and which can complex hydrophobic guest molecules.D espite the hydrophobic nature of these cavities,e arly indications for the competitive binding of ions exist. [96,99,130] Taraszewska and Wójcik were the first to correlate the small but significant binding of simple anions to a-CD and b-CD with the Hofmeister character of the anions. [99] Recently,w hile investigating interactions of large dodecaborate cluster dianions of the type B 12 X 12 2À (X = H, Cl, Br,a nd I) with g-CD,w eo bserved exceedingly high binding constants, [10] which for the first time rivaled the binding of highly hydrophobic guest molecules such as adamantane and triamantane.…”

Section: Supramolecular Chemistrymentioning

confidence: 99%

See 2 more Smart Citations

The Chaotropic Effect as an Assembly Motif in Chemistry

2018

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Following up on scattered reports on interactions of conventional chaotropic ions (for example, I−, SCN−, ClO4 −) with macrocyclic host molecules, biomolecules, and hydrophobic neutral surfaces in aqueous solution, the chaotropic effect has recently emerged as a generic driving force for supramolecular assembly, orthogonal to the hydrophobic effect. The chaotropic effect becomes most effective for very large ions that extend beyond the classical Hofmeister scale and that can be referred to as superchaotropic ions (for example, borate clusters and polyoxometalates). In this Minireview, we present a continuous scale of water–solute interactions that includes the solvation of kosmotropic, chaotropic, and hydrophobic solutes, as well as the creation of void space (cavitation). Recent examples for the association of chaotropic anions to hydrophobic synthetic and biological binding sites, lipid bilayers, and surfaces are discussed.

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Section: Thermochemical Hydration Characteristicsmentioning

confidence: 99%

Section: Examplesmentioning

confidence: 99%

Section: Supramolecular Chemistrymentioning

confidence: 99%

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The Chaotropic Effect as an Assembly Motif in Chemistry

2018

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“…To investigate iodine staining of amyloid fibrils, we analyzed changes in colors by mixing iodine solution with NaCl, SDS, or no-salt fibrils. The iodine solution, in which three types of iodine species, I -, I2, and I3 -, are present in equilibrium, shows yellowish color, and the absorption spectrum of the iodine solution shows two major peaks and one broad one derived from I3and I2, respectively 38,39 (Fig. S1).…”

Section: Resultsmentioning

confidence: 99%

“…5). Considering that I3itself does not absorb visible light so strongly 38,39 , it is predicted that I5and other polyiodide ions composed of I3and I5as fundamental building blocks, (I3 -)n and (I5 -)n, and possibly some other types of polyiodides composed of both of I3and I5 -, (I3 -)m(I5 -)n, serve as the molecular basis of color formation.…”

Section: Discussionmentioning

confidence: 99%

Iodine staining as a useful probe for distinguishing amyloid fibril polymorphs

Hiramatsu

Yamamoto

et al. 2020

Preprint

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ABSTRACTIt is recently suggested that amyloid polymorphism, i.e., structural diversity of amyloid fibrils, has a deep relationship with pathology. However, its prompt recognition is almost halted due to insufficiency of analytical methods for detecting polymorphism of amyloid fibrils sensitively and quickly. Here, we propose that iodine staining, a historically known reaction that was firstly found by Virchow, can be used as a method for distinguishing amyloid polymorphs. When insulin fibrils were prepared and iodine-stained, they exhibited different colors depending on polymorphs. Each of the colors was inherited to daughter fibrils by seeding reactions. The colors were fundamentally represented as a sum of three absorption bands in visible region between 400-750 nm, and the bands showed different titration curves against iodine, suggesting that there are three specific iodine binding sites. The analysis of resonance Raman spectra and polarization microscope suggested that several polyiodide ions composed of I3− and/or I5− were formed on the grooves or the edges of β-sheets. It was concluded that the polyiodide species and conformations formed are sensitive to surface structure of amyloid fibrils, and the resultant differences in color will be useful for detecting polymorphism in a wide range of diagnostic samples.

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Chlorella Vulgaris‐Inspired Versatile Theranostic Nanoparticles for Specific Recognition and Detoxification to Copper (II) In Vitro and In Vivo

Qi,

Tan,

Zhang

et al. 2024

Adv Funct Materials

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Specific recognition and detoxification for copper is the key step for the early diagnosis and treatment of various diseases such as neurodegenerative disease and Wilson's disease. Herein, a Chlorella vulgaris‐inspired versatile theranostic nanoparticles is facilely and greenly prepared by assembling quercetin into poly(beta‐cyclodextrin) (PQNPs), which is further employed in the specific recognition and detoxification for Cu2+ in vitro and in vivo. PQNPs can be used in the detection of Cu2+ in aqueous solutions with fast response time (<5 s) and low detection limit (6.499 nM). The detection for Cu2+ in water and serum can be achieved by naked eye instantaneously on a PQNPs‐based paper sensor, and PQNPs can also act as a biological diagnostic agent for the Cu2+ imaging. Remarkably, PQNPs significantly enhance cell viability of the cell models induced by Cu2+ through the synergistic capacities of chelating Cu2+ and antioxidation. The detoxification of PQNPs for copper poisoning model is further ascertained in vivo, and it found that poly‐β‐cyclodextrin is capable of crossing the blood–brain barrier. Taken together, the as‐prepared versatile theranostic nanoparticles possess advantages of simple composition, significant theranostic efficacy, and novel treatment pattern, presenting an intriguing avenue to develop therapeutics for tackling abnormal copper metabolism in the clinic.

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Host–Guest Inclusion Complexation of α-Cyclodextrin and Triiodide Examined Using UV–Vis Spectrophotometry

Cited by 52 publications

References 27 publications

The Chaotropic Effect as an Assembly Motif in Chemistry

The Chaotropic Effect as an Assembly Motif in Chemistry

Iodine staining as a useful probe for distinguishing amyloid fibril polymorphs

Chlorella Vulgaris‐Inspired Versatile Theranostic Nanoparticles for Specific Recognition and Detoxification to Copper (II) In Vitro and In Vivo

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