Host–Guest Interaction Driven Peptide Assembly into Photoresponsive Two-Dimensional Nanosheets with Switchable Antibacterial Activity

Xie, Xiaoming; Gao, Bo; Ma, Zhiyuan; Liu, Junqing; Zhang, Jianfeng; Liang, Jing; Chen, Zhijun; Wu, Lixin; Li, Wen

doi:10.31635/ccschem.020.202000312

Cited by 25 publications

(20 citation statements)

References 63 publications

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“…On the other hand, their self-assembly behavior could be hierarchically controlled through rational design to achieve more applications. Among the various noncovalent interactions utilized to fabricate supra-amphiphiles, host–guest interactions have attracted considerable interest because of their designability and strong complexation. , Cyclodextrins (CDs) are a class of distinctive macrocycles on account of their good solubility and biocompatibility, − which exhibit essential application in solubilizing hydrophobic drugs. − Importantly, β-CD and γ-CD possess unique α-amylase-responsive properties in which the α-1,4-glucose bonds can be cleaved . However, the host–guest interactions of CDs often suffer from weak binding affinity with guest molecules, which limits their application and development to some extent. − …”

Section: Introductionmentioning

confidence: 99%

Fluorescence “Turn-On” Enzyme-Responsive Supra-Amphiphile Fabricated by Host–Guest Recognition between γ-Cyclodextrin and a Tetraphenylethylene-Sodium Glycyrrhetinate Conjugate

Kang

et al. 2021

Langmuir

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A novel fluorescence "turn-on" enzyme-responsive supra-amphiphile is developed based on the host−guest recognition between γ-cyclodextrin (γ-CD) and an amphiphilic tetraphenylethene-sodium glycyrrhetinate conjugate (TPE-SGA). The covalent amphiphile TPE-SGA displayed strong fluorescence in aqueous solution owing to the aggregation-induced emission. Upon addition of γ-CD, the fluorescence of TPE-SGA was effectively turned off due to the host−guest recognition with γ-CD prohibiting the aggregation of TPE-SGA in aqueous solution. The as-formed nonfluorescent supra-amphiphile (TPE-SGA/γ-CD) inherited the α-amylase-responsive property of γ-CD. In the presence of α-amylase, the fluorescence of the supra-amphiphile was gradually turned on owing to the hydrolysis of γ-CD, and the fluorescence intensity linearly correlated to the activity of α-amylase. This study enriches the field of supra-amphiphile on the basis of cyclodextrin-based host−guest chemistry and provides a novel strategy to construct fluorescence turn-on functioned self-assemblies. It is anticipated that the fluorescence turn-on supra-amphiphile has potential applications in biological analysis and diagnosis of pancreatic diseases.

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Section: Introductionmentioning

confidence: 99%

Fluorescence “Turn-On” Enzyme-Responsive Supra-Amphiphile Fabricated by Host–Guest Recognition between γ-Cyclodextrin and a Tetraphenylethylene-Sodium Glycyrrhetinate Conjugate

Kang

et al. 2021

Langmuir

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“…Consequently, it is urgent to develop alternative antibacterial ways for the treatment of drug-resistant bacterial infections. [5][6][7][8][9][10][11][12] Saturated fatty acids are a class of promising biomaterials due to their low cost, biocompatibility, and biodegradability. 13,14 Among them, lauric acid (LA), a medium-chain fatty acid commonly found in coconut palm and milk, is reported to have selective bactericidal activity against Gram-positive bacteria by exerting a membrane-damaging effect.…”

Section: Introductionmentioning

confidence: 99%

An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

et al. 2022

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“…An extreme case of higher order self-assembly is the formation of supramolecular gels, basically, semi-solid materials composed of three-dimensional (3D) networked structures with a large amount of entrapped solvents (water in the case of hydrogels and other solvents for organogels) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Due to the reversible nature of the supramolecular interactions, such as hydrogen bonding, π−π stacking, hydrophobic interactions, van der Waals interactions, charge-transfer interactions, etc., the resultant gels are highly sensitive to different external stimuli and thus making those gels highly dynamic in nature [ 14 , 15 , 16 ]. Over the past couple of decades, a plethora of supramolecular gels with structural sophistication and functional variations, particularly aromatic peptides because of their built π-interactions environment, have been reported [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Peptide-Based Low Molecular Weight Photosensitive Supramolecular Gelators

Pramanik

Ahmed

2022

Gels

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Over the last couple of decades, stimuli-responsive supramolecular gels comprising synthetic short peptides as building blocks have been explored for various biological and material applications. Though a wide range of stimuli has been tested depending on the structure of the peptides, light as a stimulus has attracted extensive attention due to its non-invasive, non-contaminant, and remotely controllable nature, precise spatial and temporal resolution, and wavelength tunability. The integration of molecular photo-switch and low-molecular-weight synthetic peptides may thus provide access to supramolecular self-assembled systems, notably supramolecular gels, which may be used to create dynamic, light-responsive “smart” materials with a variety of structures and functions. This short review summarizes the recent advancement in the area of light-sensitive peptide gelation. At first, a glimpse of commonly used molecular photo-switches is given, followed by a detailed description of their incorporation into peptide sequences to design light-responsive peptide gels and the mechanism of their action. Finally, the challenges and future perspectives for developing next-generation photo-responsive gels and materials are outlined.

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Host–Guest Interaction Driven Peptide Assembly into Photoresponsive Two-Dimensional Nanosheets with Switchable Antibacterial Activity

Cited by 25 publications

References 63 publications

Fluorescence “Turn-On” Enzyme-Responsive Supra-Amphiphile Fabricated by Host–Guest Recognition between γ-Cyclodextrin and a Tetraphenylethylene-Sodium Glycyrrhetinate Conjugate

Fluorescence “Turn-On” Enzyme-Responsive Supra-Amphiphile Fabricated by Host–Guest Recognition between γ-Cyclodextrin and a Tetraphenylethylene-Sodium Glycyrrhetinate Conjugate

An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

Peptide-Based Low Molecular Weight Photosensitive Supramolecular Gelators

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