“Host-guest” interactions in Captisol®/Coumestrol inclusion complex: UV–vis, FTIR-ATR and Raman studies

Venuti, Valentina; Stancanelli, Rosanna; Acri, Giuseppe; Crupi, V.; Paladini, Giuseppe; Testagrossa, Barbara; Tommasini, S.; Ventura, Cinzia Anna; Majolino, D.

doi:10.1016/j.molstruc.2017.06.054

Cited by 21 publications

(22 citation statements)

References 53 publications

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“…Considering the experimental procedure adopted for the synthesis of the bPEI/TOUS-CNFs sponges, surface COO − /COOH groups of the CNS crystalline nano-structures, and intra-chain COO − /COOH located in amorphous regions of the reticulated polymer network (see Figure 6) were present. As already reported [58,59], the C=O stretching vibration was strongly sensitive to the surrounding electrostatic environment, since a reduction of the co-operativity experienced by C=O groups resulted in a reinforcement of the associated dipole moment, leading to a shift of the corresponding stretching vibration frequency towards higher values. Accordingly, high-wavenumber modes reasonably arose from C=O oscillators in less constrained regions having low co-ordination degree, typical of amorphous moieties.…”

Section: First Of All As Can Be Observed From Bothsupporting

confidence: 65%

2D Correlation Spectroscopy (2DCoS) Analysis of Temperature-Dependent FTIR-ATR Spectra in Branched Polyethyleneimine/TEMPO-Oxidized Cellulose Nano-Fiber Xerogels

et al. 2021

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Fourier transform infrared spectroscopy in attenuated total reflectance geometry (FTIR-ATR), combined with a 2D correlation analysis, was here employed to investigate temperature-induced spectral changes occurring in a particular type of novel cellulosic-based nano-material prepared using 2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPO) oxidized and ultra-sonicated cellulose nano-fibers (TOUS-CNFs) as three-dimensional scaffolds, and branched polyethyleneimine (bPEI) as cross-linking agent. The aim was to highlight the complex sequential events involving the different functional groups of the polymeric network, as well as to gain insight into the interplay between the amount of bPEI and the resulting sponge-like material, upon increasing temperature. In this framework, synchronous and asynchronous 2D spectra were computed and analyzed in three wavenumber regions (900–1200 cm−1, 1500–1700 cm−1 and 2680–3780 cm−1), where specific vibrational modes of the cellulosic structure fall, and over a T-range between 250 K and 340 K. A step-by-step evolution of the different arrangements of the polymer functional groups was proposed, with particular regard to how the cooperativity degree of inter- and intramolecular hydrogen bonds (HBs) changes upon heating. Information acquired can be useful, in principle, in order to develop a next-generation, T-sensitive novel material to be used for water remediation applications or for drug-delivery nano-vectors.

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Section: First Of All As Can Be Observed From Bothsupporting

confidence: 65%

2D Correlation Spectroscopy (2DCoS) Analysis of Temperature-Dependent FTIR-ATR Spectra in Branched Polyethyleneimine/TEMPO-Oxidized Cellulose Nano-Fiber Xerogels

et al. 2021

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“…Raman investigation was performed in order to get deeper information on the interactions involved in the formation of RT-SLNs, based on the significant spectral modifications induced on the characteristic vibrational bands of free RT when loaded in SLNs [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

et al. 2021

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This study was aimed at preparing and characterizing solid lipid nanoparticles loading rutin (RT-SLNs) for the treatment of oxidative stress-induced diseases. Phospholipon 80H® as a solid lipid and Polysorbate 80 as surfactant were used for the SLNs preparation, using the solvent emulsification/diffusion method. We obtained spherical RT-SLNs with low sizes, ranging from 40 to 60 nm (hydrodynamic radius) for the SLNs prepared starting from 2% and 5% (w/w) theoretical amount. All prepared formulations showed negative zeta-potential values. RT was efficiently encapsulated within SLNs, obtaining high encapsulation efficiency and drug content percentages, particularly for SLNs prepared with a 5% theoretical amount of RT. In vitro release profiles and analysis of the obtained data applying different kinetic models revealed Fickian diffusion as the main mechanism of RT release from the SLNs. The morphology of RT-SLNs was characterized by scanning electron microscopy (SEM), whereas the interactions between RT and the lipid matrix were investigated by Raman spectroscopy, evidencing spectral modifications of characteristic bands of RT due to the establishment of new interactions. Finally, antioxidant activity assay on human glioblastoma astrocytoma (U373) culture cells showed a dose-dependent activity for RT-SLNs, particularly at the highest assayed dose (50 μM), whereas the free drug showed the lesser activity.

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“…As a consequence, different drug delivery approaches were attempted to increase the transport through nasal mucosa [22]. Among them, drug–cyclodextrin complexes were proven to increase aqueous solubility, dissolution rate, and bioavailability of lipophilic drugs, as well as acting as penetration enhancers through biological membranes [24,25,26,27,28]. Moreover, cyclodextrins (CDs) can reduce or prevent degradation of drugs by enzymes, with these being largely present on the nasal mucosa surface [29].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex †

et al. 2019

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Idebenone (IDE) is an antioxidant drug active at the level of the central nervous system (CNS), whose poor water solubility limits its clinical application. An IDE/2-hydroxypropyl-β-cyclodextrin (IDE/HP-β-CD) inclusion complex was investigated by combining experimental methods and theoretical approaches. Furthermore, biological in vitro/ex vivo assays were performed. Phase solubility studies showed an AL type diagram, suggesting the presence of a 1:1 complex with high solubility. Scanning electron microscopy (SEM) allowed us to detect the morphological changes upon complexation. The intermolecular interactions stabilizing the inclusion complex were experimentally characterized by exploring the complementarity of Fourier-transform infrared spectroscopy in attenuated total reflectance geometry (FTIR-ATR) with mid-infrared light, Fourier-transform near-infrared (FT-NIR) spectroscopy, and Raman spectroscopy. From the temperature evolution of the O–H stretching band of the complex, the average enthalpy ΔHHB of the hydrogen bond scheme upon inclusion was obtained. Two-dimensional (2D) rotating frame Overhauser effect spectroscopy (ROESY) analysis and computational studies involving molecular modeling and molecular dynamics (MD) simulation demonstrated the inclusion of the quinone ring of IDE inside the CD ring. In vitro/ex vivo studies evidenced that complexation produces a protective effect of IDE against the H2O2-induced damage on human glioblastoma astrocytoma (U373) cells and increases IDE permeation through the excised bovine nasal mucosa.

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“Host-guest” interactions in Captisol®/Coumestrol inclusion complex: UV–vis, FTIR-ATR and Raman studies

Cited by 21 publications

References 53 publications

2D Correlation Spectroscopy (2DCoS) Analysis of Temperature-Dependent FTIR-ATR Spectra in Branched Polyethyleneimine/TEMPO-Oxidized Cellulose Nano-Fiber Xerogels

2D Correlation Spectroscopy (2DCoS) Analysis of Temperature-Dependent FTIR-ATR Spectra in Branched Polyethyleneimine/TEMPO-Oxidized Cellulose Nano-Fiber Xerogels

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex †

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