Host–guest interactions mediated nano-assemblies using cyclodextrin-containing hydrophilic polymers and their biomedical applications

Abstract

SummarySupramolecular nanostructures assembled by polymeric amphiphiles have been intensively studied during the last two decades. Such nanocarriers may be engineered to possess on-demand bioresponsitivity for the prevention, diagnosis, and treatment of human diseases. The successful development of several nanoassembly-based polymer therapeutics further encouraged scientists to develop nano-vehicles to achieve controlled release, enhanced efficacy, improved specificity and reduced toxicity. Different from the abundant existing literatures on the hydrophobically or electrostatically driven self-assemblies and their therapeutic applications, this article reviews hostguest interaction mediated nanoassemblies, especially those constructed using cyclodextrins as the host entities. The excellent biocompatibility, complexation capacity, and chemical-sensitivity of cyclodextrin make cyclodextrin-containing polymers attractive to construct host-guest nanoassemblies. Such nanocarriers may be advantageous also because of the broad availability of cyclodextrins, their flexibility for structure/property modulation and their chemical-responsive characteristics.

Dendrimer-like assemblies based on organoclays as multi-host system for sustained drug delivery

“…4 shows that after an equilibration time of 4 h in PBS at 40°C, the maximum loading of assemblies reached 26.8%, which was much higher than that of either the control or the previously reported b-CD containing assemblies [32] and or nanoparticles [33]. This result should be ascribed to the combined effect of the intercalation of smectite clay [9][10][11]13,14], inclusion complexation of b-CD [32,40,[48][49][50][51][52][53] and the supramolecular encapsulation [1,2,8,54]. Moreover, the highresolution FE-TEM image, as shown in Fig.…”

“…The growth medium was then replaced with fresh RPMI 1640 medium containing different concentrations (10,50,100,200 or 400 lg mL À1 ) of MTM-APTES-CD suspensions. Control cultures were grown in growth medium only.…”

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

“…Especially, CDs are capable of performing Bsite-selective complexationô n a specific segment of the block copolymer due to steric fitting, hydrophobic (or van der Waals) interactions, and/or other interactions between the cavity of the CDs and the block copolymers [8]. The resultant complex can also impart and/or enhance the amphiphilicity of the block copolymers, which in turn, can enhance further self-assembly with the formation of supramolecular structures [9].…”

Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

“…Recent reviews report host-guest polymer assemblies originated from CD polymers and their biomedical applications. [15][16][17] Zhang and Ma [17] designed different nanocarriers for drug delivery based on a double hydrophilic block copolymer [a poly(ethylene oxide) block and a bCD-containing block]. bCD grafting PEI was proposed to build nanoparticles for drug and gene delivery.…”