2022
DOI: 10.1080/19490976.2022.2044721
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Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori

Abstract: Helicobacter pylori is the major risk factor for gastric cancer. H. pylori harboring the type IV secretion system (T4SS) and its effector CagA encoded on the cag pathogenicity Island ( cag PAI) increases the risk. H. pylori PMSS1 has a multi- cagA genotype, modulating cagA copy number dynamically from zero to four copies. To examine the effect of the immune respon… Show more

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Cited by 11 publications
(4 citation statements)
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“…CagA can cause loss of tight junctions and polarity of epithelial cells by disrupting zona occludens-1 and adhesion molecules. It can also induce inflammation in gastric epithelial cells by expressing proinflammatory cytokines [ 36 ]. In vitro, H. pylori strains expressing CagA induce high IL-8 secretion in gastric epithelial cells [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…CagA can cause loss of tight junctions and polarity of epithelial cells by disrupting zona occludens-1 and adhesion molecules. It can also induce inflammation in gastric epithelial cells by expressing proinflammatory cytokines [ 36 ]. In vitro, H. pylori strains expressing CagA induce high IL-8 secretion in gastric epithelial cells [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Although the mechanism of action of metformin is unknown, it appears that this decrease occurs during the induction of immune tolerance to bacteria by metformin [ 13 ]. However, one study has shown that the expression of cagA is higher in the gastric mucosa of mice infected with H. pylori with a less severe immune response than in mice with a more severe immune response [ 36 ]. In mice lacking Treg cells, H. pylori burden is lower and gastritis is more severe [ 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…The T4SS in H. pylori is used for the injection of the oncoprotein CagA as well as for the transfer of peptidoglycan fragments (11)(12)(13)(14). CagA interferes with different metabolic pathways in gastric epithelial cells, leading to depolarisation of the cell, an increase of cell mobility and the loss of tight junctions (8,(15)(16)(17). The resulting disorganization of gastric cell structure contributes to gastric disease (18)(19)(20).…”
Section: Introductionmentioning
confidence: 99%
“…The T4SS in H. pylori is used for the injection of the oncoprotein CagA as well as for the transfer of peptidoglycan fragments (11)(12)(13)(14). CagA interferes with different metabolic pathways in gastric epithelial cells, leading to depolarisation of the cell, an increase of cell mobility and the loss of tight junctions (8,(15)(16)(17). The resulting disorganization of gastric cell structure contributes to gastric disease (18)(19)(20).…”
Section: Introductionmentioning
confidence: 99%