Host-Induced Silencing of Fusarium graminearum Genes Enhances the Resistance of Brachypodium distachyon to Fusarium Head Blight

He, Fuxin; Zhang, Ruiming; Zhao, Jiaxin; Qi, Tuo; Kang, Zhensheng; Guo, Jun

doi:10.3389/fpls.2019.01362

Cited by 24 publications

(8 citation statements)

References 57 publications

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“…HIGS technologies has been used in different crops to control a variety of fungal species as shown by several scientific reports [ 151 , 160 , 161 , 162 , 163 , 164 , 165 ]. Among these, Mahto et al published in 2020 [ 166 ] the first evidence for the control of anthracnose in chilly and tomato.…”

Section: Innovative and Sustainable Approachesmentioning

confidence: 99%

Management of Post-Harvest Anthracnose: Current Approaches and Future Perspectives

Ciofini

Negrini

Baroncelli

et al. 2022

Plants

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Anthracnose is a severe disease caused by Colletotrichum spp. on several crop species. Fungal infections can occur both in the field and at the post-harvest stage causing severe lesions on fruits and economic losses. Physical treatments and synthetic fungicides have traditionally been the preferred means to control anthracnose adverse effects; however, the urgent need to decrease the use of toxic chemicals led to the investigation of innovative and sustainable protection techniques. Evidence for the efficacy of biological agents and vegetal derivates has been reported; however, their introduction into actual crop protection strategies requires the solutions of several critical issues. Biotechnology-based approaches have also been explored, revealing the opportunity to develop innovative and safe methods for anthracnose management through genome editing and RNA interference technologies. Nevertheless, besides the number of advantages related to their use, e.g., the putative absence of adverse effects due to their high specificity, a number of aspects remain to be clarified to enable their introduction into Integrated Pest Management (IPM) protocols against Colletotrichum spp. disease.

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Section: Innovative and Sustainable Approachesmentioning

confidence: 99%

Management of Post-Harvest Anthracnose: Current Approaches and Future Perspectives

Ciofini

Negrini

Baroncelli

et al. 2022

Plants

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“…Similarly, host susceptibility genes could be explored to disable these deleterious genes through mutagenesis or editing through CRISPR/Cas9 (Wang et al, 2014). Host-induced gene silencing (HIGS) through the production of small interfering RNA molecules (RNAi) as demonstrated recently in wheat and model organism B. distachyon for FHB resistance could be further utilized (Cheng et al, 2015;He et al, 2019). However, regulatory hurdles have limited success for obtaining improved FHB resistant cultivars via a transgenic approach.…”

Section: Modern Genomic Approaches For Breeding Fhb Resistancementioning

confidence: 99%

Fusarium Head Blight and Rust Diseases in Soft Red Winter Wheat in the Southeast United States: State of the Art, Challenges and Future Perspective for Breeding

et al. 2020

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Among the biotic constraints to wheat (Triticum aestivum L.) production, fusarium head blight (FHB), caused by Fusarium graminearum, leaf rust (LR), caused by Puccinia triticina, and stripe rust (SR) caused by Puccinia striiformis are problematic fungal diseases worldwide. Each can significantly reduce grain yield while FHB causes additional food and feed safety concerns due to mycotoxin contamination of grain. Genetic resistance is the most effective and sustainable approach for managing wheat diseases. In the past 20 years, over 500 quantitative trait loci (QTLs) conferring small to moderate effects for the different FHB resistance types have been reported in wheat. Similarly, 79 Lr-genes and more than 200 QTLs and 82 Yr-genes and 140 QTLs have been reported for seedling and adult plant LR and SR resistance, respectively. Most QTLs conferring rust resistance are race-specific generally conforming to a classical gene-for-gene interaction while resistance to FHB exhibits complex polygenic inheritance with several genetic loci contributing to one resistance type. Identification and deployment of additional genes/ QTLs associated with FHB and rust resistance can expedite wheat breeding through marker-assisted and/or genomic selection to combine small-effect QTL in the gene pool. LR disease has been present in the southeast United States for decades while SR and FHB have become increasingly problematic in the past 20 years, with FHB arguably due to increased corn acreage in the region. Currently, QTLs on chromosome 1B from

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“…Apart from inserting foreign genes, the interference of pathogens biology via RNAi also holds a great promise for managing the disease. RNAi is highly useful for the regulation of protein-coding genes at the transcriptional and post-transcriptional levels [ 137 ]. This technology is used to modify the host defense via Host Induced Gene Silencing (HIGS).…”

Section: Remodeling Host Defensementioning

confidence: 99%

Omics Insight on Fusarium Head Blight of Wheat for Translational Research Perspective

Teli

Purohit²,

Rashid

et al. 2020

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: In the scenario of global warming and climate change, an outbreak of new pests and pathogens has become a serious concern owing to the rapid emergence of arms races, their epidemic infection, and the ability to break down host resistance, etc. Fusarium head blight (FHB) is one such evidence that depredates major cereals throughout the world. The symptomatological perplexity and aetiological complexity make this disease very severe, engendering significant losses in the yield. Apart from qualitative and quantitative losses, mycotoxin production solemnly deteriorates the grain quality in addition to life endangerment of humans and animals after consumption of toxified grains above the permissible limit. To minimize this risk, we must be very strategic in designing sustainable management practices constituting cultural, biological, chemical, and host resistance approaches. Even though genetic resistance isthe most effective and environmentally friendly strategy, a huge genetic variation and unstable resistance response limit the holistic deployment of resistance genes in FHB management. Thus, the focus must shift towardsthe editing of susceptible (S) host proteins that are soft targets of newly evolving effector molecules, which ultimately could be exploited to repress the disease development process. Hence, we must understand the pathological, biochemical, and molecular insight of disease development in a nutshell.In the present time,the availability of functional genomics, proteomics, and metabolomics information on host-pathogen interaction in FHB have constructed various networks whichhelped in understanding the events of pathogenesis and coherent host response(s). So now translation of this information for designing of host defense in the form of desirable resistant variety/genotype is the next step. The insightscollected and presented in this review will be aiding understanding the disease and apprise a solution to the multi-faceted problems which are related to FHB resistance in wheat and other cereals to ensure global food safety and food security.

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Host-Induced Silencing of Fusarium graminearum Genes Enhances the Resistance of Brachypodium distachyon to Fusarium Head Blight

Cited by 24 publications

References 57 publications

Management of Post-Harvest Anthracnose: Current Approaches and Future Perspectives

Management of Post-Harvest Anthracnose: Current Approaches and Future Perspectives

Fusarium Head Blight and Rust Diseases in Soft Red Winter Wheat in the Southeast United States: State of the Art, Challenges and Future Perspective for Breeding

Omics Insight on Fusarium Head Blight of Wheat for Translational Research Perspective

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