Host–pathogen interaction after infection of <i>Galleria mellonella</i> with the filamentous fungus <i>Beauveria bassiana</i>

Vertyporokh, Lidiia; Hułas-Stasiak, Monika; Wojda, Iwona

doi:10.1111/1744-7917.12706

Cited by 23 publications

(17 citation statements)

References 44 publications

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“…Furthermore, the synergism between grooming, burrowing and even temperature rise induced by sun can limit the infection of entomopathogenic fungi (Ortiz-Urquiza & Keyhani, 2013). Internally, the insect's immune system plays an important role in regulating the response to infection by entomopathogenic fungi by involving hemocytes (granulocytes and plasmocytes) in hemolymph, which promotes the encapsulation of B. bassiana hifal bodies (Vertyporokh et al, 2019). In terms of humoral immunity, the induction of heat shock (43 °C/15 min) in Galleria mellonella larvae promotes the expression of antifungal compounds such as gallerimicin and galiomicin, and also increases the activity of lysozyme (Wojda et al, 2009).…”

Section: General Overview On the Pathogenesis Of Beauveria Bassianamentioning

confidence: 99%

Beauveria bassiana secondary metabolites: a review inside their production systems, biosynthesis, and bioactivities

Ávila‐Hernández¹,

Carrillo-Inungaray²,

Quiroz³

et al. 2020

Mexjbiotechnol

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The application of entomopathogenic fungi as biological control agent is an activity that has been carried out for a long time because they can regulate insect pests through specific formulations of spores and blastospores as infective units, as well as their endophytic ability in some plants offers protection against plant pathogens. Due to its wide distribution and antagonistic ability, Beauveria bassiana is widely used all around the world. Among its main mechanisms of infection is the REVIEW ARTICLE

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Section: General Overview On the Pathogenesis Of Beauveria Bassianamentioning

confidence: 99%

Beauveria bassiana secondary metabolites: a review inside their production systems, biosynthesis, and bioactivities

Ávila‐Hernández¹,

Carrillo-Inungaray²,

Quiroz³

et al. 2020

Mexjbiotechnol

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“…To date, the genome‐wide gene expression profiles on fungal entomopathogens challenges have been characterized in many insect species, such as Bombyx mori , G . mellonella , Melanotus cribricollis , Plutella xylostella and Riptortus pedestris 15–19 . However, few reports have explored the insect‐fungus interaction of BPH during M. anisopliae infection, which extremely impeded the genetic improvement of the fungal entomopathogen against BPH 20 …”

Section: Introductionmentioning

confidence: 99%

Comprehensive insights into host‐pathogen interaction between brown planthopper and a fungal entomopathogen by dual RNA sequencing

Wang

Pan

et al. 2021

Pest Management Science

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BACKGROUND The brown planthopper (BPH) is one of the most destructive pests of rice, causing tremendous yield and economic losses every year. The fungal entomopathogen Metarhizium anisopliae was previously proved to have great potential for BPH biocontrol. Genome‐wide insight into the insect‐fungus interaction is crucial for genetic improvement of M. anisopliae to enhance its virulence to BPH but still has been poorly explored. RESULTS Using dual RNA‐seq approach, we present here a global view of host and fungal gene expressions in BPH adults during the fungal infection. The results revealed that BPH could initiate strong defense responses against the fungal attack by upregulating the expressions of a large number of genes, including genes involved in cuticle formation, immune response, cell detoxification and biomacromolecule metabolism. Correspondingly, the fungal entomopathogen could induce a series of genes to infect and modulate BPH, including genes involved in fungal penetration, invasive growth, stress resistance and virulence. Three host defense‐related genes (NlPCE4, NlPOD1 and NlCYP4DE1) were chosen for further function analysis. RNAi‐mediated knockdown of NlPCE4 caused a significant decrease in BPH survival, but no obvious effects on the survival rates were detected by the suppression of NlPOD1 and NlCYP4DE1. Combination of dsRNA injection and fungal infection could significantly enhance the BPH‐killing speed, as synergistic mortalities were observed in co‐treatments of RNAi and M. anisopliae infection. CONCLUSION Our study provides a comprehensive insight into molecular mechanisms of host‐pathogen interaction between BPH and M. anisopliae and contributes to future development of new efficient biocontrol strategies for BPH biocontrol.

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“…In the host hemolymph, Beauveria bassiana grows as single yeast-like cells with very thin cell walls; blastospores isolated from the hemolymph show carbohydrate epitope shielding that protects the cells from immune recognition [ 106 , 109 , 110 , 111 ]; moreover, the shift to blastospores reduces the number of PAMPs on the cell surface, reducing the effectiveness of recognition by the host PRRs [ 112 ].…”

Section: Entomopathogensmentioning

confidence: 99%

When Appearance Misleads: The Role of the Entomopathogen Surface in the Relationship with Its Host

Brivio

Mastore

2020

Insects

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Currently, potentially harmful insects are controlled mainly by chemical synthetic insecticides, but environmental emergencies strongly require less invasive control techniques. The use of biological insecticides in the form of entomopathogenic organisms is undoubtedly a fundamental resource for the biological control of insect pests in the future. These infectious agents and endogenous parasites generally act by profoundly altering the host’s physiology to death, but their success is closely related to the neutralization of the target insect’s immune response. In general, entomopathogen parasites, entomopathogenic bacteria, and fungi can counteract immune processes through the effects of secretion/excretion products that interfere with and damage the cells and molecules typical of innate immunity. However, these effects are observed in the later stages of infection, whereas the risk of being recognized and neutralized occurs very early after penetration and involves the pathogen surface components and molecular architecture; therefore, their role becomes crucial, particularly in the earliest pathogenesis. In this review, we analyze the evasion/interference strategies that entomopathogens such as the bacterium Bacillus thuringiensis, fungi, nematocomplexes, and wasps implement in the initial stages of infection, i.e., the phases during which body or cell surfaces play a key role in the interaction with the host receptors responsible for the immunological discrimination between self and non-self. In this regard, these organisms demonstrate evasive abilities ascribed to their body surface and cell wall; it appears that the key process of these mechanisms is the capability to modify the surface, converting it into an immunocompatible structure, or interaction that is more or less specific to host factors.

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Host–pathogen interaction after infection of Galleria mellonella with the filamentous fungus Beauveria bassiana

Cited by 23 publications

References 44 publications

Beauveria bassiana secondary metabolites: a review inside their production systems, biosynthesis, and bioactivities

Beauveria bassiana secondary metabolites: a review inside their production systems, biosynthesis, and bioactivities

Comprehensive insights into host‐pathogen interaction between brown planthopper and a fungal entomopathogen by dual RNA sequencing

When Appearance Misleads: The Role of the Entomopathogen Surface in the Relationship with Its Host

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