Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

Chudnovskiy, Aleksey; Mortha, Arthur; Kana, Veronika; Kennard, Andrea; Ramírez, Juan David; Rahman, Adeeb; Remark, Romain; Mogno, Ilaria; Ng, Ruby; Gnjatic, Sacha; Amir, El ad David; Solovyov, Alexander; Greenbaum, Benjamin; Clemente, José C.; Faith, Jeremiah J.; Belkaid, Yasmine; Grigg, Michael E.; Mérad, Miriam

doi:10.1016/j.cell.2016.08.076

Cited by 275 publications

(335 citation statements)

References 52 publications

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“…These results together with the high expression of the IL-18 receptor IL-18Rα on colonic-infiltrating effector T cells suggested that T. musculis-specific T cell immunity is likely initiated in the draining lymph nodes by migratory colonic DCs and is likely propagated at the tissue site by epithelial IL-18 (91). Interestingly, T.…”

Section: Role Of the Protozoan Microbiota In Infection And Inflammationmentioning

confidence: 98%

Parasitic Protozoa and Interactions with the Host Intestinal Microbiota

et al. 2017

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Parasitic protozoan infections represent a major health burden in the developing world and contribute significantly to morbidity and mortality. These infections are often associated with considerable variability in clinical presentation. An emerging body of work suggests that the intestinal microbiota may help to explain some of these differences in disease expression. The objective of this minireview is to synthesize recent progress in this rapidly advancing field. Studies of humans and animals and in vitro studies of the contribution of the intestinal microbiota to infectious disease are discussed. We hope to provide an understanding of the human-protozoal pathogen-microbiome interaction and to speculate on how that might be leveraged for treatment.

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Section: Role Of the Protozoan Microbiota In Infection And Inflammationmentioning

confidence: 98%

Parasitic Protozoa and Interactions with the Host Intestinal Microbiota

et al. 2017

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“…These now include protozoans such as Tritrichomonas spp 67, 68 . and a human isolate of Bifidobacterium adolescentis 69 .…”

Section: Segmented Filamentous Bacteria (Sfb) and Reproducibilitymentioning

confidence: 99%

Microbiota and reproducibility of rodent models

2017

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The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and pre-clinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.

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“…Animals from different sources are now well known to have very different commensal composition [11, 44, 107]. One hypothesis for these differences between studies is that there are unique factors in the gut other than the microbiome that can affect macrophage replacement from blood monocytes but that specific bacterial species present in certain mouse colonies can enhance or decrease the turnover rate.…”

Section: Introductionmentioning

confidence: 99%

Macrophages in gastrointestinal homeostasis and inflammation

Grainger

Konkel

Zangerle-Murray

et al. 2017

Pflugers Arch - Eur J Physiol

129

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Monocyte-derived mononuclear phagocytes, particularly macrophages, are crucial to maintain gastrointestinal homeostasis in the steady state but are also important for protection against certain pathogens. However, when uncontrolled, they can promote immunopathology. Broadly two subsets of macrophages can be considered to perform the vast array of functions to complete these complex tasks: resident macrophages that dominate in the healthy gut and inflammation-elicited (inflammatory) macrophages that derive from circulating monocytes infiltrating inflamed tissue. Here, we discuss the features of resident and inflammatory intestinal macrophages, complexities in identifying and defining these populations and the mechanisms involved in their differentiation. In particular, focus will be placed on describing their unique ontogeny as well as local gastrointestinal signals that instruct specialisation of resident macrophages in healthy tissue. We then explore the very different roles of inflammatory macrophages and describe new data suggesting that they may be educated not only by the gut microenvironment but also by signals they receive during development in the bone marrow. Given the high degree of plasticity of gut macrophages and their multifaceted roles in both healthy and inflamed tissue, understanding the mechanisms controlling their differentiation could inform development of improved therapies for inflammatory diseases such as inflammatory bowel disease (IBD).

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Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

Cited by 275 publications

References 52 publications

Parasitic Protozoa and Interactions with the Host Intestinal Microbiota

Parasitic Protozoa and Interactions with the Host Intestinal Microbiota

Microbiota and reproducibility of rodent models

Macrophages in gastrointestinal homeostasis and inflammation

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