Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection

Helbling, Beat; Overbeck, Kathrin Stéphanie; Gonvers, J. J.; Malinverni, R.; Dufour, Jean‐François; Borovicka, Jan; Heim, Markus H.; Cerny, Andreas; Negro, Francesco; Bucher, Stephan; Rickenbach, Martin; Renner, E L; Müllhaupt, Beat

doi:10.1136/gut.2007.142844

Cited by 45 publications

(45 citation statements)

References 43 publications

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“…8,10,38 However, in contrast to previous investigations, 10,38 higher ALT concentrations in this study were associated with decreased SF-36 scores in five domains and in two summary components. As CHC has been associated with several extrahepatic manifestations, 3 one may speculate that elevated ALT concentrations might be associated with the activation of a systemic host immune response.…”

Section: Discussioncontrasting

confidence: 99%

“…Helbling et al showed that low income was the major factor associated with a reduced HRQOL among patients with CHC. 10 In addition, previous investigations have demonstrated the positive influence of education on the HRQOL of patients with this disease. 3,4 Of note, regarding host-related variables, it should be emphasized that the majority of studies assessing the HRQOL of patients affected by CHC have taken place in the context of routine medical care and did not use structured psychiatric interviews to confirm anxiety or mood disorders.…”

Section: Discussionmentioning

confidence: 96%

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Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Silva

Cunha

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: Patients with chronic hepatitis C (CHC) have a poorer quality of life than those with other chronic liver diseases. However, some of the factors that determine health-related quality of life (HRQOL) in these patients, such as the degree of liver fibrosis, are still controversial. Therefore, the aim of the present study was to investigate the impact of CHC on HRQOL by conducting clinical, psychiatric, and sociodemographic evaluations. Methods: One hundred and twenty-four consecutive patients attending a referral center for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview, the Hamilton Depression Rating Scale, the Hospital Anxiety and Depression Scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey. Multiple linear regression analyses were used to quantify independent associations between HRQOL and the clinical, psychiatric, and sociodemographic variables of interest. Results: Reduced HRQOL was independently associated with major depressive disorder (MDD) and with elevated levels of alanine aminotransferase, but was not associated with hepatic cirrhosis. Conclusions: MDD rather than the grade of liver fibrosis was strongly associated with HRQOL impairment in patients with CHC. These findings highlight that, in patients with CHC, the psychological effects of the disease deserve more attention and the implementation of integrated medical, psychiatric, and psychological care may be helpful.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Silva

Cunha

et al. 2015

Rev. Bras. Psiquiatr.

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“…Extrahepatic manifestations of HCV infection may be less important as they are uncommon (although the association between HCV infection and non-Hodgkin lymphoma needs confirmation). The knowledge of one's infection status is a major determinant of altered quality of life because of the increased anxiety caused by the uncertain progression of the disease with its potential consequences (83), and therefore the screening for hepatitis C in 'healthy' subjects has to be undertaken with all due ethical, medical and psychological precautions.…”

Section: Natural History Parameters Morbidity and Mortalitymentioning

confidence: 99%

The global burden of hepatitis C

Lavanchy

2009

Liver International

1,223

904

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Hepatitis C is of concern both to industrialized and developing countries. Preliminary unpublished estimates of the global burden of disease (GBD) attributable to HCV-related chronic liver disease seem to be substantial. Therefore, the reduction of global mortality and morbidity related to chronic hepatitis C should be a concern to public health authorities, and primary, secondary and tertiary prevention activities should be implemented and monitored in each country, with precise targets set to be reached. In order to decide on national health policies, there is a need to estimate the burden of disease, globally, regionally and nationally. To evaluate the GBD, three components have to be assessed: 1) The global, regional and national burden of morbidity and mortality associated with HCV infection, based on prevalence, incidence, transmission and economics; 2) The natural history of HCV infection, including 'healthy individuals'; and 3) The areas for which more research is needed. A working group was created to assist the World Health organization (WHO) in estimating the GBD associated with HCV infection.

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“…In fact, with sociodemographic variables, such as income, marital status, age or education, co-morbidities had important effects on global QoL of patients living with hepatitis C 19,20 . Because of the close relationship between income and education, it is not easy to discuss specifically the influence of hepatitis C in the association between low income or education level and poor QoL found in this study.…”

Section: Referencesmentioning

confidence: 99%

Quality of life of patients with hepatitis C

Alves

Baldessar

Pereira

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Self-report on the quality of life (QOL) is increasingly studied in the evaluation of various diseases, especially in chronic ones. However, there are few data in the literature focusing the QOL of patients living with chronic hepatitis C. The objective of this study was to evaluate the QOL in patients with hepatitis C assessed by the World Health Organization Quality of Life Assessment (WHOQOL)-bref scale. Methods: One hundred and eight hepatitis C patients attending the Outpatient Healthcare Medical Specialties in Tubarão, State of Santa Catarina, Brazil, were contacted from May 2010 to February 2011. Patients answered the WHOQOL-bref scale and a questionnaire about their treatment and risk factors to hepatitis C virus (VHC) infection. Results: Although most of patients with chronic hepatitis C considered their QoL good or very good (58.1%), 47 (44.8%) patients were poorly or very poorly satisfied with their health. About the WHOQOL answers, the environment domain had the highest score (25.15 + 5.77), while the lowest score was the social relationships domain (9.19 + 2.5). There was statistically significant association between household income and quality of life in all domains (p<0.001) and statistically significant association between education and the physical, psychological and social domains of quality of life (p<0.05). Conclusions: Based on the answers given in WHOQOL-bref, patients with chronic hepatitis C have a generally poor QOL, especially in social relationship domain. Household income and educational level were factors that interfered significantly with patients' QOL assessment.

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Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection

Abstract: Anti-HCV-positive subjects have decreased HRQOL compared to controls. The magnitude of this decrease was clinically important for the SF-36 vitality score. Host and environmental, rather than viral factors, seem to impact on HRQOL level.

Cited by 45 publications

References 43 publications

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

The global burden of hepatitis C

Quality of life of patients with hepatitis C

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