2013
DOI: 10.4161/viru.24724
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Host resistance influences patterns of experimental viral adaptation and virulence evolution

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Cited by 22 publications
(33 citation statements)
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“…A very general finding from serial passage experiments in a wide range of host-parasite systems, including Plasmodium chabaudi in lab mice, is that pathogens become more virulent to the serial passage host (Ebert 1998;Mackinnon and Read 2004a;Barclay et al 2012;Kubinak et al 2012;Kubinak and Potts 2013;Spence et al 2013). These patterns are assumed to be a consequence of pathogen adaptation to the serial passage host, since serial passage selects for higher pathogen densities at the time of transfer.…”
Section: The Experimentsmentioning
confidence: 96%
“…A very general finding from serial passage experiments in a wide range of host-parasite systems, including Plasmodium chabaudi in lab mice, is that pathogens become more virulent to the serial passage host (Ebert 1998;Mackinnon and Read 2004a;Barclay et al 2012;Kubinak et al 2012;Kubinak and Potts 2013;Spence et al 2013). These patterns are assumed to be a consequence of pathogen adaptation to the serial passage host, since serial passage selects for higher pathogen densities at the time of transfer.…”
Section: The Experimentsmentioning
confidence: 96%
“…It is often viewed as a means to an end—enhanced growth and dissemination to other hosts (57, 118). However, enterococcal infection in humans and close relatives with a long history of hygienic funerary rituals (95) is an evolutionary dead end.…”
Section: Evolution Of Enterococcal Virulence Factorsmentioning
confidence: 99%
“…Thus, one 'same host genotype' and one 'different host genotypes' virus stock were created for each of the independent BALB/c and DBA/2J experiments. A total of six different mouse strains were used for these five-round serial-passage experiments and all have previously been shown (BALB/c, DBA/2J, 129X1/svj, A.SW, BALB.KK) [20][21][22], or are shown here (electronic supplementary material figure S2), to be susceptible to FV complex infection. Infected animals were monitored daily, with each round of infection lasting 10-12 days depending on the health status of the animal.…”
Section: (I) Five-round Serial Passage Experimentsmentioning
confidence: 99%
“…Moreover, resistance variability among host genotypes can significantly influence both the magnitude of an adaptive response and the degree of host specialization (i.e. magnitude of fitness trade-offs) exhibited by this pathogen [22]. These data suggest that genetic diversity among hosts may constrain the evolution of more virulent infectious diseases.…”
Section: Introductionmentioning
confidence: 99%