Host resistance to Hymenolepis nana. II. Specificity of resistance to reinfection in the direct cycle

Weinmann, C. J.

doi:10.1016/0014-4894(64)90044-x

Cited by 21 publications

(6 citation statements)

References 36 publications

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“…brasiliensis infections were only observed during the time of expulsion of each parasite. Expulsion of T. spiralis caused a premature loss of N. brasiliensis in concurrent infections, a result which is in agreement with similar work with other helminths (Weinmann, 1964;Stahl, 1966;Bruce & Wakelin, 1977;Behnke, Bland & Wakelin, 1977;Moqbel & Wakelin, 1979). The expulsion of N. brasiliensis, likewise, caused a premature loss of T. spiralis and Tables 5 and 6 show that T. spiralis was affected in the following ways: (a) premature loss of worms, (6) re-location of worms into more posterior parts of the gut, (c) impaired growth and (d) depressed fecundity.…”

Section: Discussionsupporting

confidence: 91%

Immunologically mediated, non-specific interactions between the intestinal phases ofTrichinella spiralisandNippostrongylus brasiliensisin the mouse

1980

Parasitology

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SummaryInteractions between infections of Trichinella spiralis and Nippostrongylus brasiliensis were studied in the NIH strain of mouse which is known to react strongly to T. spiralis. The course of N. brasiliensis infection in this strain of mouse is described and expulsion is shown to be accelerated in immunized mice and inhibited in cortisone-treated mice. There was no evidence of inter-specific competition between the two species of worm in concurrent infections; the number and location of adults of both species were normal and T. spiralis was able to grow and reproduce normally. No evidence was found of direct immunological cross-reaction between N. brasiliensis and T. spiralis as assessed by the kinetics of adult worm numbers on heterologous challenge of immunized mice 90 days after the initiation of the last of 3 immunizing infections. Interaction was observed only when the timing of concurrent infections was such that one species was established in the intestine immediately before the beginning of expulsion of the second species. Interaction was manifested as a premature loss of worms and, in addition, as impairment of growth and fecundity of T. spiralis. These effects on T. spiralis were similar to those observed as a consequence of a specific immune response to T. spiralis. The rapidity of appearance of these effects and the lack of direct cross-immunity between the two species of worm suggest that the events involved in interaction were non-specific in action and possibly due to environmental changes in the gut caused by the immune response. These non-specific effects are therefore analogous, but not necessarily homologous, to the expulsion of these parasites in single species infections.

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Section: Discussionsupporting

confidence: 91%

Immunologically mediated, non-specific interactions between the intestinal phases ofTrichinella spiralisandNippostrongylus brasiliensisin the mouse

1980

Parasitology

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“…Recently, we found that Rowett strain rats, either euthymic or not, are highly resistant to infection with the mouse tapeworm Hymenolepis nana, except when they are treated with cortisone acetate (ITO, 1982(ITO, , 1983ITO & KAMIYAMA, 1984) and confirmed previous observations that the rat is an unnatural host for the mouse strain of H. nana (SHORB, 1933;HEYNEMAN, 1962;WEINMANN, 1964).…”

Section: Introductionsupporting

confidence: 86%

Cortisone-sensitive, innate resistance toHymenolepis nanainfection in congenitally athymic nude rats

Ito

Kamiyama

1987

J. Helminthol.

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The innate resistance of the unnatural rat host to the mouse tapeworm Hymenolepis nana is cortisone sensitive but thymus independent. When congenitally athymic nude rats were orally given eggs, cysticercoids, or adult worms of H. nana, no lumenal adults were established except when they were treated with cortisone acetate during the expected lumenal development. The effect of cortisone to promote adult maturation in the rats was compared in nude and normal rats given eggs of H. nana. The fecundity of the worm (assessed by the fresh worm biomass and the number of infective eggs produced) was much higher in cortisone-treated nude rats than in cotrisone-trated norml rats. When the nude rats recostituted with thymocytes were given eggs and treated with cortisone, the fecundity of H. nana dropped to the same level as in cortisone-treated normal rats. It is strongly suggested that the unnatural rat host has thymus-independent cortisone sensitive resistance to an intial infection (which is the main component of the innate resistance and blocks the lumenal establishment of this parasite) and thymus-dependent resistance (which suppresses the established worm' fecudity and may be ascribed to acquired resistance to the ongoing infection).

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“…Much of the previous work on interaction between helminths in the intestinal environment has concentrated on aspects such, as parasite distribution, physiological and nutritional effects (reviewed by Schad, 1966;Crompton, 1973). Although the host's immune response against one or both species of parasites has been considered as an important factor in interactions (Larsh & Donaldson, 1944;Cox, 1952;Larsh & Campbell, 1952;Louch, 1962;Weinmann, 1964;Courtney & Forrester, 1973;Bruce & Wakelin, 1977), in many cases the work was carried out before information on the specific mechanisms of the host response became available. Its interpretation in the light of this subsequent knowledge is made difficult because, very often, controls of one or other of the concurrent infections were omitted.…”

Section: Introductionmentioning

confidence: 99%

Effect of the expulsion phase of Trichinella spiralis on Hymenolepis diminuta infection in mice

1977

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Host resistance to Hymenolepis nana. II. Specificity of resistance to reinfection in the direct cycle

Cited by 21 publications

References 36 publications

Immunologically mediated, non-specific interactions between the intestinal phases ofTrichinella spiralisandNippostrongylus brasiliensisin the mouse

Immunologically mediated, non-specific interactions between the intestinal phases ofTrichinella spiralisandNippostrongylus brasiliensisin the mouse

Cortisone-sensitive, innate resistance toHymenolepis nanainfection in congenitally athymic nude rats

Effect of the expulsion phase of Trichinella spiralis on Hymenolepis diminuta infection in mice

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