Host Response Cytokine Signatures in Viral and Nonviral Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Almansa, Raquel; Sanchez-Garcia, Monica; Herrero, Agueda; Calzada, Sergio; Roig, Vicente; Barbado, Julia; Rico, Lucía; Bobillo, Felipe; Eiros, Jose M.; Iglesias, Verónica; Lejarazu, Raúl Ortíz de; Bermejo-Martín, Jesús F.

doi:10.1089/jir.2010.0131

Cited by 35 publications

(27 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, levels of endothelin 1, a potent vasoconstrictor and bronchoconstrictor peptide with important proinflammatory activities in the airways, tend to be higher during COPD exacerbation associated with viral or chlamydial infection, both in sputum and in plasma 212. Virus-induced COPD exacerbations are also associated with increased plasma levels of IL-10, IL-12, and IL-15,213 whereas all COPD exacerbations (with or without respiratory virus isolation) are characterized by increased plasma levels of IL-2, IL-13, and vascular endothelial growth factor 213…”

Section: Cytokines In Copd Exacerbationsmentioning

confidence: 99%

Cytokine inhibition in the treatment of COPD

Caramori¹,

Adcock²,

Stefano³

et al. 2014

COPD

View full text Add to dashboard Cite

Cytokines play an important part in many pathobiological processes of chronic obstructive pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and altered innate immune response. Proinflammatory cytokines of potential importance include tumor necrosis factor (TNF)-α, interferon-γ, interleukin (IL)-1β, IL-6, IL-17, IL-18, IL-32, and thymic stromal lymphopoietin (TSLP), and growth factors such as transforming growth factor-β. The current objectives of COPD treatment are to reduce symptoms, and to prevent and reduce the number of exacerbations. While current treatments achieve these goals to a certain extent, preventing the decline in lung function is not currently achievable. In addition, reversal of corticosteroid insensitivity and control of the fibrotic process while reducing the emphysematous process could also be controlled by specific cytokines. The abnormal pathobiological process of COPD may contribute to these fundamental characteristics of COPD, and therefore targeting cytokines involved may be a fruitful endeavor. Although there has been much work that has implicated various cytokines as potentially playing an important role in COPD, there have been very few studies that have examined the effect of specific cytokine blockade in COPD. The two largest studies that have been reported in the literature involve the use of blocking antibody to TNFα and CXCL8 (IL-8), and neither has provided benefit. Blocking the actions of CXCL8 through its CXCR2 receptor blockade was not successful either. Studies of antibodies against IL-17, IL-18, IL-1β, and TSLP are currently either being undertaken or planned. There is a need to carefully phenotype COPD and discover good biomarkers of drug efficacy for each specific target. Specific groups of COPD patients should be targeted with specific anticytokine therapy if there is evidence of high expression of that cytokine and there are features of the clinical expression of COPD that will respond.

show abstract

Section: Cytokines In Copd Exacerbationsmentioning

confidence: 99%

Cytokine inhibition in the treatment of COPD

Caramori¹,

Adcock²,

Stefano³

et al. 2014

COPD

View full text Add to dashboard Cite

show abstract

“…Although individual cytokine signals in early SIV infection have been measured previously, the ability to measure multiple protein analytes simultaneously and sensitively by cytokine bead multiplex assay has allowed a more comprehensive approach to the study of inflammatory mediators in acute viral infections (4,(20)(21)(22). Cytokine multiplex assays have been developed using antibodies against human cytokines that were found to be crossreactive with NHP analytes.…”

mentioning

confidence: 99%

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates

Keating

Heitman

et al. 2016

J Virol

View full text Add to dashboard Cite

Acute human immunodeficiency virus (HIV) infection represents a period of intense immune perturbation and activation of the host immune system. Study of the eclipse and viral expansion phases of infection is difficult in humans, but studies in nonpro- IMPORTANCENHP models of HIV infection constitute a powerful tool with which to study viral pathogenesis in order to gain critical information for a better understanding of HIV infection in humans. Here we studied progressive and nonprogressive simian immunodeficiency virus (SIV) infection models in both natural and nonnatural host NHP species. Regardless of the pathogenicity of the virus infection and regardless of the NHP species studied, the magnitude of viremia, as measured by area under the curve, during the first 4 weeks of infection correlated positively with viremia in chronic infection. The magnitude of cytokine and chemokine responses during primary infection also correlated positively with both acute-phase and chronic viremia. However, the pattern and levels of specific cytokines and chemokines produced differed between nonprogressive and progressive SIV infection models. The qualitative differences in the early immune response in pathogenic and nonpathogenic infections identified here may be important determinants of the subsequent disease course.

show abstract

“…In both subgroups, the TNF- α levels declined in the sputum, although the decline in TNF- α blood levels was not significant. Almansa et al [30] and Pinto-Plata et al [31] measured various inflammatory cytokines before and after treatment of AECOPD. Their results showed that serum IL-8 expression was significantly reduced but that TNF- α did not change significantly; these findings are consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lianhuaqingwen Capsules on Airway Inflammation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Dong

Xia

Gong

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory response that is worsened by acute exacerbations. Lianhuaqingwen (LHQW) has anti-inflammatory and immune regulatory functions and may inhibit the airway inflammation that occurs during an acute exacerbation of COPD. In this study, 100 participants were recruited and randomly assigned, 1 : 1, to the LHQW and the conventional groups, which were treated, respectively, with LHQW capsules and conventional Western medicine or only conventional Western medicine. The scores of the CAT scale and levels of inflammatory cytokines in blood and sputum were measured during treatment. In addition, subjects were subdivided into high-risk and low-risk subgroups. The CAT scores in the LHQW group and high-risk subgroup were clearly improved from the 5th day, but the other groups improved only after treatment was completed. Expression levels of IL-8, TNF-α, IL-17, and IL-23 in the sputum and of IL-8 and IL-17 in the blood were significantly decreased after treatment, and similar results were found in subgroups. These data suggested that LHQW capsules can accelerate the improvement of AECOPD patients, especially for the high-risk subgroup, and the mechanism of action may be related to the decreased release of inflammatory mediators.

show abstract

Host Response Cytokine Signatures in Viral and Nonviral Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Cited by 35 publications

References 12 publications

Cytokine inhibition in the treatment of COPD

Cytokine inhibition in the treatment of COPD

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates

Effect of Lianhuaqingwen Capsules on Airway Inflammation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About