Host response modulation in the management of periodontal diseases

Salvi, Giovanni E.; Lang, Niklaus P.

doi:10.1111/j.1600-051x.2005.00785.x

Cited by 237 publications

(251 citation statements)

References 239 publications

Supporting

Mentioning

229

Contrasting

Unclassified

Order By: Relevance

“…2). And several clinical studies indicated that the concentration of PGE 2 in gingival crevicular fluid (GCF) is increased in periodontal disease 23) and is decreased by the administration of NSAIDs such as oral administration with flurbiprofen 24) and mouse wash with ketrolac.…”

Section: Discussionmentioning

confidence: 99%

“…1) Periodontal disease comprises a group of infections that leads to inflammation of the gingiva and destruction of periodontal tissues, and is accompanied by alveolar bone loss in severe clinical cases. The tissue destruction is the result of activation of the host's immuno-inflammatory response to virulence factors 2) such as lipopolysaccharide (LPS) and peptidoglycan. The elimination of these virulence factors by initial preparation is very important for the treatment of periodontal disease.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts

Ara

Maeda

Fujinami

et al. 2008

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

In the present study, we investigated the anti-inflammatory effects of a Kampo medicine Shosaikoto (TJ-9) using in vitro periodontal disease model, in which human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS) from Porphyromonas gingivalis (PgLPS) produce IL-6, IL-8 and prostaglandin E 2 (PGE 2 ). Treatment with PgLPS (10 ng/ml), TJ-9 (up to 1 mg/ml) and their combinations for 24 h did not affect the viability of HGFs. Moreover, TJ-9 did not alter LPS-induced IL-6 and IL-8 productions. However, TJ-9 significantly suppressed LPS-induced PGE 2 production in a dose-dependent manner but TJ-9 alone did not affect basal PGE 2 level. Western blotting demonstrated that TJ-9 decreased cyclooxygenase-2 (COX-2) expression in a dosedependent manner but not phospholipase A 2 . Moreover, TJ-9 selectively and dose-dependently inhibited COX-2 activity. These results suggest that TJ-9 decreased PGE 2 production by inhibition of both COX-2 expression and activity and that TJ-9 may be useful to improve gingival inflammation in periodontal disease.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts

Ara

Maeda

Fujinami

et al. 2008

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…Chronic bacterial exposure is sine qua non for gingival inflammation and destruction of tooth supporting structure. [1] A small group of mainly microaerophilic bacteria, Gramnegative, or anaerobic bacteria in the biofilm are important for induction and advancement of periodontal destruction. Pathogens actively involved as etiologic agents include Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia.…”

Section: Introductionmentioning

confidence: 99%

Host modulation therapy: An updated review

Ipshita¹,

Kurian²,

Dileep³

et al. 2017

JCRI

View full text Add to dashboard Cite

show abstract

“…Severe periodontitis is known to affect approximately 10%-15% of the population. 1,2 Periodontal destruction is mediated by the host's immune-inflammatory response 3 elicited by pathogendominated biofilms. This response leads to the production of specific antibodies and inflammatory mediators within the local tissues, as well as a systemically elicited response.…”

Section: Introductionmentioning

confidence: 99%

Supragingival biofilm control and systemic inflammation in patients with type 2 diabetes mellitus

et al. 2015

View full text Add to dashboard Cite

The objective of this study was to evaluate the effect of strict supragingival biofilm control on serum inflammatory markers and on periodontal clinical parameters in type 2 diabetes mellitus (T2DM) patients with chronic severe periodontitis. Twenty-four individuals with T2DM and periodontitis were randomly allocated to two treatment groups. The supragingival therapy group (ST, n = 12) received supragingival scaling, whereas the intensive therapy group (IT, n = 12) underwent supra-and subgingival scaling, as well as root planing. Patients from both groups received professional oral hygiene instructions every month. Data regarding visible plaque index (VPI), gingival bleeding index (GBI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), serum levels of interleukin (IL)-6, IL-17A, IL-8, tumor necrosis factor α (TNF-α), monocyte chemoattractant protein (MCP)-1 enzyme-linked immunosorbent assay (ELISA), and glycated hemoglobin (HbA1c) levels were obtained at baseline and at 6 months post-therapy. Both therapies resulted in the improvement of almost all clinical periodontal parameters (p < 0.05). There were no differences in TNF-α, IL-8, IL-17A and HbA1c levels in either group (p > 0.05), between the two periods. However, MCP-1 levels were significantly reduced in both the ST (p = 0.034) and the IT (p = 0.016) groups, whereas the serum IL-6 levels were significantly reduced only in the IT group (p = 0.001). Strict control of supragingival biofilm has a limited effect on systemic inflammatory markers, and a moderate effect on periodontal clinical parameters.

show abstract

Host response modulation in the management of periodontal diseases

Abstract: After validation in long-term clinical trials, adjunctive host modulation therapy may prove advantageous in the management of periodontal diseases.

Cited by 237 publications

References 239 publications

Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts

Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts

Host modulation therapy: An updated review

Supragingival biofilm control and systemic inflammation in patients with type 2 diabetes mellitus

Contact Info

Product

Resources

About