2014
DOI: 10.1371/journal.ppat.1004266
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Host Responses to Group A Streptococcus: Cell Death and Inflammation

Abstract: Infections caused by group A Streptococcus (GAS) are characterized by robust inflammatory responses and can rapidly lead to life-threatening disease manifestations. However, host mechanisms that respond to GAS, which may influence disease pathology, are understudied. Recent works indicate that GAS infection is recognized by multiple extracellular and intracellular receptors and activates cell signalling via discrete pathways. Host leukocyte receptor binding to GAS-derived products mediates release of inflammat… Show more

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Cited by 46 publications
(46 citation statements)
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“…Multiple reports have described a pivotal role for poreforming toxins in other bacteria in shaping host leukocyte responses, including the GAS cytotoxins SLO and SLS [29,30] . Virulent GAS bestowed with covRS mutations are highly encapsulated, and express higher levels of SLO, so PMN necrosis is likely due in part to cytolysin-expressing extracellular GAS.…”
Section: Discussionmentioning
confidence: 99%
“…Multiple reports have described a pivotal role for poreforming toxins in other bacteria in shaping host leukocyte responses, including the GAS cytotoxins SLO and SLS [29,30] . Virulent GAS bestowed with covRS mutations are highly encapsulated, and express higher levels of SLO, so PMN necrosis is likely due in part to cytolysin-expressing extracellular GAS.…”
Section: Discussionmentioning
confidence: 99%
“…Both mild and severe forms of GAS diseases are mediated by a suite of secreted and membrane-associated virulence factors that interact with the human host (3, 4). Trafficking and secretion of GAS proteins have long been assumed to be solely dependent on the canonical general secretory (Sec) translocation pathway.…”
Section: Introductionmentioning
confidence: 99%
“…S. pyogenes infection results in a severe inflammatory response that involves the production of a number of effectors, including ROS, cytokines, and a spectrum of acute-phase reactants (23). Strikingly, S. pyogenes lacks common oxidative stress resistance factors such as catalase (24).…”
mentioning
confidence: 99%