Host shifts result in parallel genetic changes when viruses evolve in closely related species

Longdon, Ben; Day, Jonathan P.; Alves, Joel M.; Smith, Sophia C. L.; Houslay, Thomas M.; McGonigle, John E; Tagliaferri, Lucia; Jiggins, Francis M.

doi:10.1101/226175

Cited by 12 publications

(14 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most mutations were deleterious in the original and taxonomically related hosts, and a larger fraction of mutations were beneficial in hosts from unrelated families, in which the fitness of the wild type TEV genotype was low. In agreement with these results, it has been shown that adaptation to a new host may result in adaptation to closely related hosts, which will favour virus jumps to related species [15]. In another study, seven genotypes of pepper mild mottle virus (PMMoV) with coat protein mutations determining the overcoming of different resistance alleles in pepper, were assayed in five susceptible pepper genotypes [16 ].…”

Section: Virus-intrinsic Factors In Host Range Evolutionmentioning

confidence: 67%

Evolution of plant–virus interactions: host range and virus emergence

McLeish

Fraile

García‐Arenal

2019

Current Opinion in Virology

View full text Add to dashboard Cite

Changes in host range are central to virus emergence. Host range, together with its evolution, is determined by virus intrinsic factors, such as genetic traits determining its fitness in different hosts. Experimental analyses have shown the relevance in host range evolution of across-host fitness tradeoffs. Host range is also determined by ecological factors extrinsic to the virus such as the distribution, abundance, and interaction of species, and understanding their role in host range evolution is a current challenge. Indeed, intrinsic and extrinsic factors, and the complexity of biotic and abiotic interactions, must be considered in order to provide generalisations on patterns of transmission, host range evolution, and disease emergence. This exciting new field of research is still in its infancy.

show abstract

Section: Virus-intrinsic Factors In Host Range Evolutionmentioning

confidence: 67%

Evolution of plant–virus interactions: host range and virus emergence

McLeish

Fraile

García‐Arenal

2019

Current Opinion in Virology

View full text Add to dashboard Cite

show abstract

“…The influence of these factors depends on the viral population’s life history and, therefore, careful consideration is needed to design and interpret evolutionary experiments to study the evolutionary potential of viruses and inform prediction. In the context of strong selection on specific phenotypes, the evolutionary response to selection is often repeatable and involves only a few mutations (Longdon et al, 2017; Morley and Turner, 2017; Stern et al, 2017; Weinreich et al, 2006; Xiao et al, 2017; Xue et al, 2017). However, when considering more complex outcomes, such as spillover events, environmental and epidemiological factors add layers of additional complexity that must be considered (Campbell et al, 2018; Geoghegan and Holmes, 2017).…”

Section: Discussionmentioning

confidence: 99%

Mapping the Evolutionary Potential of RNA Viruses

Dolan

Whitfield

Andino

2018

Cell Host & Microbe

View full text Add to dashboard Cite

The deterministic force of natural selection and stochastic influence of drift shape RNA virus evolution. New deep-sequencing and microfluidics technologies allow us to quantify the effect of mutations and trace the evolution of viral populations with single-genome and single-nucleotide resolution. Such experiments can reveal the topography of the genotype-fitness landscapes that shape the path of viral evolution. By combining historical analyses, like phylogenetic approaches, with high-throughput and high-resolution evolutionary experiments, we can observe parallel patterns of evolution that drive important phenotypic transitions. These developments provide a framework for quantifying and anticipating potential evolutionary events. Here, we examine emerging technologies that can map the selective landscapes of viruses, focusing on their application to pathogenic viruses. We identify areas where these technologies can bolster our ability to study the evolution of viruses and to anticipate and possibly intervene in evolutionary events and prevent viral disease.

show abstract

“…We used Drosophila C virus (DCV) strain B6A (Longdon et al., 2018), which is derived from an isolate collected from D. melanogaster in Charolles, France (Jousset et al., 1972). The virus was prepared as described previously (Longdon et al., 2013).…”

Section: Methodsmentioning

confidence: 99%

Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios

Roberts

Longdon

2021

J of Evolutionary Biology

Self Cite

View full text Add to dashboard Cite

The likelihood of a successful host shift of a parasite to a novel host species can be influenced by environmental factors that can act on both the host and parasite. Changes in nutritional resource availability have been shown to alter pathogen susceptibility and the outcome of infection in a range of systems. Here, we examined how dietary protein to carbohydrate altered susceptibility in a large cross‐infection experiment. We infected 27 species of Drosophilidae with an RNA virus on three food types of differing protein to carbohydrate ratios. We then measured how viral load and mortality across species was affected by changes in diet. We found that changes in the protein:carbohydrate in the diet did not alter the outcomes of infection, with strong positive inter‐species correlations in both viral load and mortality across diets, suggesting no species‐by‐diet interaction. Mortality and viral load were strongly positively correlated, and this association was consistent across diets. This suggests changes in diet may give consistent outcomes across host species, and may not be universally important in determining host susceptibility to pathogens.

show abstract

Host shifts result in parallel genetic changes when viruses evolve in closely related species

Cited by 12 publications

References 57 publications

Evolution of plant–virus interactions: host range and virus emergence

Evolution of plant–virus interactions: host range and virus emergence

Mapping the Evolutionary Potential of RNA Viruses

Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios

Contact Info

Product

Resources

About