Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii)

Kang, Hae Ji; Bennett, Shannon N.; Dizney, Laurie; Sumibcay, Laarni; Arai, Satoru; Ruedas, Luis A.; Song, Jin Won; Yanagihara, Richard

doi:10.1016/j.virol.2009.03.019

Cited by 78 publications

(102 citation statements)

References 37 publications

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“…Parameters were reestimated during successive rounds of ML heuristic searches using the tree bisection reconnection (TBR) and subtree-pruning-regrafting (SPR) algorithms implemented in PAUP*. 22 Nearly identical tree topologies, well-supported by bootstrap analysis (> 70%) and posterior node probabilities (> 0.70), were estimated from analysis of the partial S-, M-, and L-segment sequences of TPMV from Nepal, which formed a monophyletic group with the prototype TPMV strain from India ( Figure 2 ).…”

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confidence: 99%

“…22 All TPMVinfected shrews from Nepal were confirmed as Asian house shrews by phylogenetic analysis of cytochrome b sequences of multiple shrew species available in GenBank. 32 This seemingly trivial finding firmly established that the Asian house shrew is the natural reservoir of TPMV and dismissed lingering doubts that another shrew or rodent species might be involved.…”

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confidence: 99%

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Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Kang¹,

Kosoy²,

Shrestha³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. Despite the recent discovery of genetically divergent hantaviruses in shrews of multiple species in widely separated geographic regions, data are unavailable about the genetic diversity and phylogeography of Thottapalayam virus (TPMV), a hantavirus originally isolated from an Asian house shrew ( Suncus murinus ) captured in southern India more than four decades ago. To bridge this knowledge gap, the S, M, and L segments of hantavirus RNA were amplified by reverse transcription polymerase chain reaction from archival lung tissues of Asian house shrews captured in Nepal from January to September 1996. Pair-wise alignment and comparison revealed approximately 80% nucleotide and > 94% amino acid sequence similarity to prototype TPMV. Phylogenetic analyses, generated by maximum likelihood and Bayesian methods, showed geographic-specific clustering of TPMV, similar to that observed for rodent-and soricid-borne hantaviruses. These findings confirm that the Asian house shrew is the natural reservoir of TPMV and suggest a longstanding virus-host relationship.

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confidence: 99%

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confidence: 99%

Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Kang¹,

Kosoy²,

Shrestha³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…cross-species transmission, followed by local host adaptation [35]. Increasing evidence suggests that in addition to rodents, shrews and moles also serve as hosts for hantaviruses [35,36,37,38].…”

Section: Evolution Of Hantavirusesmentioning

confidence: 99%

“…Care should be taken to distinguish shrews and moles from rodents as they differ in many characteristics, such as evolution, taxonomic order and lifespan, while at the same time sharing the common trait of inhabiting the same environmental communities, which sheds light on our understanding of host switching. This could occur following inter-or intra-species wounding or by virus shedding in respiratory secretions or excretions within the same ecological niche [35,40]. Immunologically-based mechanisms of persistence of hantaviruses in shrews and moles appear similar to those which are thought to have occurred in rodents throughout evolutionary history [41].…”

Section: Evolution Of Hantavirusesmentioning

confidence: 99%

Effects of Anthropogenic Events and Viral Persistence on Rodent Reservoirs of Hantavirus Infection: Understanding Host-Pathogen Interactions Facilitates Novel Approaches to Intervention Strategies

Mahmud-Al-Rafat¹,

E-Sobhani²,

Taylor‐Robinson³

2015

AJIDM

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Hantaviruses are primarily rodent-borne pathogens which have received considerable attention recently due to their high mortality rates in humans. In order to find the causes of rapid transmission and emergence of hantavirus-associated diseases anthropogenic changes are a priority. These include deforestation, urbanization, noise pollution, light pollution and electromagnetic fields, all of which have been shown to profoundly affect rodent physiology and immunology. Moreover, anthropogenic events promote human-rodent co-habitation and thereby provide a driver to increase rates of transmission and, by extrapolation, levels of infection in humans. Such environmental disruption acts as a chronic stressor to rodents and causes elevated concentrations of glucocorticoids, which are a major class of immunosuppressive hormone. Glucocorticoids are responsible for altering the immune tolerance of rodents, thereby rendering them susceptible to infection. Glucocorticoids induce regulatory T lymphocytes to reduce inflammatory and antiviral responses and to activate regulatory responses, principally through production of the cytokines interleukin-10 and transforming growth factor-β to support viral persistence. In order to develop a low-cost intervention strategy for hantavirus infection consideration should be given to a systemic approach to therapy. This would both aim to achieve a reduction of anthropogenic stressors and to gain a greater understanding of host-pathogen interactions.

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“…The discovery of HTNV also made possible the identification of hantaviruses such as Sin Nombre virus (SNV), Black Creek Canal virus (BCCV), and Andes virus (ANDV), harbored by sigmodontine and neotomine rodent species, which cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas (39,43,51). Recently, the reservoir host range has been expanded with the discovery of highly divergent lineages of hantaviruses in shrews (2,3,5,28,30,(52)(53)(54), moles (4,(27)(28)(29) and bats (57,58), but their pathogenic potential in humans is not known.…”

Section: Introductionmentioning

confidence: 99%

Hantaviruses Induce Antiviral and Pro-Inflammatory Innate Immune Responses in Astrocytic Cells and the Brain

Shin

Song²,

Kumar

et al. 2014

Viral Immunology

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Although hantaviruses are not generally considered neurotropic, neurological complications have been reported occasionally in patients with hemorrhagic fever renal syndrome (HFRS). In this study, we analyzed innate immune responses to hantavirus infection in vitro in human astrocytic cells (A172) and in vivo in suckling ICR mice. Infection of A172 cells with pathogenic Hantaan virus (HTNV) or a novel shrew-borne hantavirus, known as Imjin virus (MJNV), induced activation of antiviral genes and pro-inflammatory cytokines/chemokines. MicroRNA expression profiles of HTNV-and MJNV-infected A172 cells showed distinct changes in a set of miRNAs. Following intraperitoneal inoculation with HTNV or MJNV, suckling ICR mice developed rapidly progressive, fatal central nervous system-associated disease. Immunohistochemical staining of virus-infected mouse brains confirmed the detection of viral antigens within astrocytes. Taken together, these findings suggest that the neurological findings in HFRS patients may be associated with hantavirus-directed modulation of innate immune responses in the brain.

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Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii)

Cited by 78 publications

References 37 publications

Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Effects of Anthropogenic Events and Viral Persistence on Rodent Reservoirs of Hantavirus Infection: Understanding Host-Pathogen Interactions Facilitates Novel Approaches to Intervention Strategies

Hantaviruses Induce Antiviral and Pro-Inflammatory Innate Immune Responses in Astrocytic Cells and the Brain

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