Host‐tumor Antagonism. Xxxvi. Auto‐immune Disease and Cancer: A Correlation of Data on the Lymphocyte, Thymus, Homograft Rejection and Somatic Mutation*

Pelner, F.A.C.A. Louis

doi:10.1111/j.1532-5415.1966.tb02898.x

Cited by 1 publication

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of white blood cells and major histocompatibility antigens in the rejection of tumors implanted in experimental animals has been well-established for several decades [1]. Both the innate, mediated by monocytes and NK-cells, and the adaptive immune response, mediated by B-and T-lymphocytes, are involved in the immune system surveillance over tumors.…”

Section: Introductionmentioning

confidence: 99%

Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review

Koukourakis

Platoni

Tiniakos

et al. 2023

CIMB

View full text Add to dashboard Cite

It is well-established that tumor antigens and molecules expressed and secreted by cancer cells trigger innate and adaptive immune responses. These two types of anti-tumor immunity lead to the infiltration of the tumor’s microenvironment by immune cells with either regulatory or cytotoxic properties. Whether this response is associated with tumor eradication after radiotherapy and chemotherapy or regrowth has been a matter of extensive research through the years, mainly focusing on tumor-infiltrating lymphocytes and monocytes and their subtypes, and the expression of immune checkpoint and other immune-related molecules by both immune and cancer cells in the tumor microenvironment. A literature search has been conducted on studies dealing with the immune response in patients with rectal cancer treated with neoadjuvant radiotherapy or chemoradiotherapy, assessing its impact on locoregional control and survival and underlying the potential role of immunotherapy in the treatment of this cancer subtype. Here, we provide an overview of the interactions between local/systemic anti-tumor immunity, cancer-related immune checkpoint, and other immunological pathways and radiotherapy, and how these affect the prognosis of rectal cancer patients. Chemoradiotherapy induces critical immunological changes in the tumor microenvironment and cancer cells that can be exploited for therapeutic interventions in rectal cancer.

show abstract

Section: Introductionmentioning

confidence: 99%