Host–virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptor

Ohishi, Kazue; Ando, Akiko; Suzuki, Rintaro; Takishita, Kiyotaka; Kawato, Masaru; Katsumata, Etsuko; Ohtsu, Dai; Okutsu, Kenji; Tokutake, Koji; Miyahara, Hirokazu; Nakamura, H.; Murayama, Tomonori; Maruyama, Tadashi

doi:10.1016/j.cimid.2008.10.003

Cited by 48 publications

(66 citation statements)

References 50 publications

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“…Four binding sites (sites 1-4) have important interactions, and electrical interaction has a significant effect on the binding. We have reported that three-dimensional (3D) homology models of marine mammals SLAMs are useful in estimating their morbillivirus sensitivities (Ohishi et al 2010(Ohishi et al , 2012.…”

Section: Introductionmentioning

confidence: 99%

Recent Host Range Expansion of Canine Distemper Virus and Variation in Its Receptor, the Signaling Lymphocyte Activation Molecule, in Carnivores

Ohishi

Suzuki

Maeda

et al. 2014

Journal of Wildlife Diseases

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ABSTRACT:The signaling lymphocyte activation molecule (SLAM) is a receptor for morbilliviruses. To understand the recent host range expansion of canine distemper virus (CDV) in carnivores, we determined the nucleotide sequences of SLAMs of various carnivores and generated three-dimensional homology SLAM models. Thirty-four amino acid residues were found for the candidates binding to CDV on the interface of the carnivore SLAMs. SLAM of the domestic dog (Canis lupus familiaris) were similar to those of other members of the suborder Caniformia, indicating that the animals in this group have similar sensitivity to dog CDV. However, they were different at nine positions from those of felids. Among the nine residues, four of domestic cat (Felis catus) SLAM (72, 76, 82, and 129) and three of lion (Panthera leo persica) SLAM (72, 82, and 129) were associated with charge alterations, suggesting that the felid interfaces have lower affinities to dog CDV. Only the residue at 76 was different between domestic cat and lion SLAM interfaces. The domestic cat SLAM had threonine at 76, whereas the lion SLAM had arginine, a positively charged residue like that of the dog SLAM. The cat SLAM with threonine is likely to have lower affinity to CDV-H and to confer higher resistance against dog CDV. Thus, the four residues (72, 76, 82, and 129) on carnivore SLAMs are important for the determination of affinity and sensitivity with CDV. Additionally, the CDV-H protein of felid strains had a substitution of histidine for tyrosine at 549 of dog CDV-H and may have higher affinity to lion SLAM. Three-dimensional model construction is a new risk assessment method of morbillivirus infectivity. Because the method is applicable to animals that have no information about virus infection, it is especially useful for morbillivirus risk assessment and wildlife conservation.

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Section: Introductionmentioning

confidence: 99%

Recent Host Range Expansion of Canine Distemper Virus and Variation in Its Receptor, the Signaling Lymphocyte Activation Molecule, in Carnivores

Ohishi

Suzuki

Maeda

et al. 2014

Journal of Wildlife Diseases

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“…The cetacean and pinniped SLAMs showed the greatest homology with those of artiodactyla (cow and sheep, 84-85% identity at the amino acid level) and of dogs (84%), respectively. Manatee SLAM shared the greatest homology with that of the elephant (86%) [71]. …”

Section: Primary Structure Of Slam Proteinsmentioning

confidence: 99%

“…Previously, we constructed 3D homology models based on the crystallographic structure of the human NTB-A molecule, a member of the SLAM family, as a template [71,75]. In the present study, we generated a new version of the models by adding the recently determined crystal structure information of the bound complex of MV H and marmoset SLAM V [56].…”

Section: Three-dimensional Models Of Marine Mammal Slam Extracellularmentioning

confidence: 99%

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Host-Virus Specificity of the Morbillivirus Receptor, SLAM, in Marine Mammals: Risk Assessment of Infection Based on Three-Dimensional Models

Ohishi¹,

Suzuki²,

Maruyama³

2012

New Approaches to the Study of Marine Mammals

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“…The PDV H gene was targeted for its importance in determining host-virus specificity, tropism, and cytopathogenicity (Von Messling et al 2004Messling et al , 2006Ohishi et al 2008). The GAPDH gene was selected to allow detection of host RNA in a wide variety of seal species.…”

Section: Introductionmentioning

confidence: 99%

DEVELOPMENT OF A ONE-STEP DUPLEX RT-qPCR FOR THE QUANTIFICATION OF PHOCINE DISTEMPER VIRUS

Bogomolni

Frasca

Matassa

et al. 2015

Journal of Wildlife Diseases

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ABSTRACT:Worldwide, stranded marine mammals and the network personnel who respond to marine mammal mortality have provided much of the information regarding marine morbillivirus infections. An assay to determine the amount of virus present in tissue samples would be useful to assist in routine surveying of animal health and for monitoring large-scale die-off events. False negatives from poor-quality samples prevent determination of the true extent of infection, while only small amounts of tissue samples or archived RNA may be available at the time of collection for future retrospective analysis. We developed a one-step duplex real-time reverse transcriptasequantitative-PCR assay (RT-qPCR) based on Taqman probe technology to quantify phocine distemper virus (PDV) isolated from an outbreak in harbor (Phoca vitulina concolor) and gray seals (Halichoerus grypus) along the northeast US coast in 2006. The glyceraldehyde-3-phosphatedehydrogenase (GAPDH) gene was selected to assess RNA quality. This duplex assay is specific for PDV and sensitive through a range of 10 0 to 10 9 copies ds-plasmid DNA. For the GAPDH target, the reaction in duplex amplified 10 0 to 10 9 copies of ds-plasmid DNA and was detectable in multiple seal species. This assay reduced the likelihood of false negative results due to degradation of tissues and well-to-well variability while providing sensitive and specific detection of PDV, which would be applicable in molecular epidemiologic studies and pathogen detection in field and laboratory investigations involving a variety of seal species.

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Host–virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptor

Cited by 48 publications

References 50 publications

Recent Host Range Expansion of Canine Distemper Virus and Variation in Its Receptor, the Signaling Lymphocyte Activation Molecule, in Carnivores

Recent Host Range Expansion of Canine Distemper Virus and Variation in Its Receptor, the Signaling Lymphocyte Activation Molecule, in Carnivores

Host-Virus Specificity of the Morbillivirus Receptor, SLAM, in Marine Mammals: Risk Assessment of Infection Based on Three-Dimensional Models

DEVELOPMENT OF A ONE-STEP DUPLEX RT-qPCR FOR THE QUANTIFICATION OF PHOCINE DISTEMPER VIRUS

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