Hosting of the antibiotic Vancomycin by bentonite: Characterization and slow release study

Martín, S. A.; Pérez, Irela; Rivera, A.

doi:10.1016/j.clay.2020.105965

Cited by 9 publications

(10 citation statements)

References 55 publications

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“…The band at 1637 cm −1 can be attributed to the bending vibration in the plane of water (𝛿 𝑂−𝐻 ). The intense band about 985 cm −1 corresponds to the Si-O stretching vibrations of the tetrahedral sheet (𝜈 𝑆𝑖−𝑂 ) (see Figure 4) [17,[45][46][47]. Lastly, the signal around 1456 cm −1 is due to stretching vibration of carbonate anion (𝜈 𝐶𝑂 3 2− ) as a spurious phase present in the raw sample [17,46].…”

Section: Characterization Of Raw and Composite Materialsmentioning

confidence: 96%

“…Based on the advantageous properties of the clays and clay minerals-ion exchange, adsorption, swelling, and rheological behavior-and their use as support [11][12][13][14][15], the pharmaceutical and cosmetic industries have an increasing interest in incorporating these materials to their products. In this sense, a special emphasis has been made in natural resources by their abundance, low cost, and environmental friendliness [16][17][18][19]. Thus, it is worth underlining the employment of clays in skin care formulations [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid

et al. 2023

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L-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have been developed in order to preserve its chemical stability, connected with its antioxidant power, but there is little research regarding the employment of natural clays as LAA host. A safe bentonite (Bent)—which was verified by in vivo ophthalmic irritability and acute dermal toxicity assays—was used as carrier of LAA. The supramolecular complex between LAA and clay may constitute an excellent alternative, since the molecule integrity does not seem to be affected, at least from the point of view of its antioxidant capacity. The Bent/LAA hybrid was prepared and characterized through ultraviolet (UV) spectroscopy, X-ray diffraction (XRD), infrared (IR) spectroscopy, thermogravimetric analysis (TG/DTG) and zeta potential measurements. Photostability and antioxidant capacity tests were also performed. The LAA incorporation into Bent clay was demonstrated, as well as the drug stability due to the Bent photoprotective effect onto the LAA molecule. Moreover, the antioxidant capacity of the drug in the Bent/LAA composite was confirmed.

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Section: Characterization Of Raw and Composite Materialsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid

et al. 2023

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“…Adsorption type sustained release agent is the original drug adsorption in inorganic, organic and other adsorbent carriers, as storage, such as attapulgite [8], bentonite [9], sepiolite [10], diatomite [11], zeolite [12], resin [13], etc. The preparation process of adsorbent sustained-release agent is simple, short time and low cost.…”

Section: Introductionmentioning

confidence: 99%

Study on Sustained-Release Pesticides Blended with Fosthiazate-Stearic Acid/Expanded Perlite

Huang¹,

Wu²,

Zhou³

et al. 2023

Journal of Renewable Materials

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The low utilization rate of pesticides makes the migration of pesticides in water and soil, which brings great harm to the ecosystem. The development of pesticide carriers with good drug loading capacity and release control ability is an effective method to realize effective utilization of pesticides and reduce pesticide losses. In this work, fosthiazate-stearic acid/expanded perlite sustained-release particles were successfully prepared by vacuum impregnation using expanded perlite (EP) as carrier, fosthiazate (FOS) as model pesticide and stearic acid (SA) as hydrophobic matrix. The structure and morphology of the samples were studied by BET, FT-IR, TGA, XRD, DSC and SEM. The effects of different mass ratios of FOS to SA on loading capacity and release rate at 24 h were investigated. The sustained release behavior of FOS-SA/EP at different temperatures and pH values was investigated by static dialysis bag method. The results showed that FOS and SA were adsorbed in EP pores by physical interaction. With the mass ratios of FOS to SA decreasing from 7:3 to 3:7, the 24 h release rate of FOS-SA/EP decreased from 18.77% to 8.05%, and the drug loading decreased from 461.32 to 130.99 mg/g. FOS-SA/EP showed obvious temperature response at 25°C, 30°C and 35°C, the cumulative release rate (CRR) of 200 h were 33.38%, 41.50% and 51.17%, respectively. When pH = 5, the CRR of FOS was higher than that of pH = 7, and the CRR of FOS for 200 h were 49.01% and 30.12%, respectively. At different temperatures and pH = 5, the release mechanism of FOS-SA/EP belongs to the Fickian diffusion mechanism; When pH = 7, the diffusion mechanism is dominant, and the dissolution mechanism is complementary.

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“…Possessing unique physical and chemical properties, such high-performance material is characterized by low price, abundant reserves, high biological safety and high stability. Therefore, it has developed rapidly in drug delivery systems in recent years and has attracted attention from people [ 4 , 5 , 6 , 7 ]. Attapulgite (ATP), also known as palygorskite, is a fibrous hydrated magnesium aluminum silicate clay mineral.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the Potential Application of Na-Attapulgite as an Excipient in Domperidone Sustained-Release Tablets

Xiao

Zheng

et al. 2022

Molecules

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In this study, Na-attapulgite was explored as an excipient to prepare domperidone sustained-release tablets and test them in accordance with United States Pharmacopoeia requirements. Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC) were employed to explore the compatibility between Na-attapulgite and domperidone. The XRD and DSC show no interaction between the drug and Na-attapulgite. The FTIR spectrum indicates a shift in the absorption of N-H in the drug molecule, which can be explained by the hydrogen bonding interaction between the N-H in the DOM molecule and the -OH on the surface of Na-ATP. The diameter, hardness, friability and drug content of the tablets were measured, and they all met the relevant requirements of the United States Pharmacopoeia. In addition, the tablets with Na-attapulgite as excipient exhibit a better release performance within the release time of 12 h. These results demonstrate that the domperidone sustained-release tablets have been successfully prepared by using Na-attapulgite as an excipient. The doping of Na-ATP in domperidone sustained-release tablets improves the cytocompatibility. Moreover, with the increase of Na-ATP content, cells proliferate remarkably and cell activity is significantly enhanced.

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Hosting of the antibiotic Vancomycin by bentonite: Characterization and slow release study

Cited by 9 publications

References 55 publications

Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid

Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid

Study on Sustained-Release Pesticides Blended with Fosthiazate-Stearic Acid/Expanded Perlite

Investigation on the Potential Application of Na-Attapulgite as an Excipient in Domperidone Sustained-Release Tablets

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