Intercultural translation is a salient feature of communicative interactions in multilingual institutional spaces. This article draws on a concept of intercultural translation that functions as a linguistically radical strategy through which other ways of knowing and being are introduced, with particular emphasis on institutions, multilingualism, and less-translated languages. It describes the modes in which indigenous actors used intercultural translation to modify Mexico’s institutional tutoring program in higher education. It focuses on the selective appropriation of words and meanings, the standardization of concepts, and the configuring of an intercultural frame of reference, whereby members of an intercultural Mexican university introduced the Yucatec Maya word iknal as a hybrid educational system. In sum, the article posits intercultural translation as a critical communicative practice ubiquitous to the dynamics of language in socio-cultural spaces.