Hot Melt Extrusion: A Process Overview and Use in Manufacturing Solid Dispersions of Poorly Water‐Soluble Drugs

Shu, Li; Jones, David S.; Andrews, Gavin

doi:10.1002/9781118444726.ch11

Cited by 4 publications

(3 citation statements)

References 121 publications

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“…Additional advantages compared to the continuous operation are a solvent-free and cost-efficient process [8] as well as a modular set-up of the screw configuration [9]. Due to the incorporation of different element types, e.g., conveying or kneading, also several unit operations can be combined within one processing step such as melting, dissolving reacting or degassing [10,11].…”

Section: Introductionmentioning

confidence: 99%

Investigations Concerning the Residence Time Distribution of Twin-Screw-Extrusion Processes as Indicator for Inherent Mixing

2018

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Over recent years Twin-Screw-Extrusion (TSE) has been established as a platform technology for pharmaceutical manufacturing. Compared to other continuous operation, one of the major benefits of this method is the combination of several unit operations within one apparatus. Several of these are linked to the Residence Time Distribution (RTD), which is typically expressed by the residence time density function. One relevant aspect for pharmaceutical processes is the mixing capacity, which is represented by the width of this distribution. In the frame of this study the influence of the mass flow, the temperature and the screw-barrel clearance were investigated for a constant barrel load (specific feed load, SFL). While the total mass flow as well as the external screw diameter affected the mixing performance, the barrel temperature had no influence for the investigated range. The determined results were additionally evaluated with respect to a fit to the Twin-Dispersion-Model (TDM). This model is based on the superimposition of two mixing functions. The correlations between varied process parameters and the obtained characteristic model parameters proved this general physical view on extrusion.

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Section: Introductionmentioning

confidence: 99%

Investigations Concerning the Residence Time Distribution of Twin-Screw-Extrusion Processes as Indicator for Inherent Mixing

2018

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“…Intermittent extrusion applies pressure to the material through a plunger. While this provides a higher pressure than screw extruders, its ability to generate significant shear action is limited, and its operation is discontinuous, which limits its application range [ 94 ].…”

Section: Pla Composite Materialsmentioning

confidence: 99%

Biodegradable Polylactic Acid and Its Composites: Characteristics, Processing, and Sustainable Applications in Sports

Gao

et al. 2023

Polymers

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Polylactic acid (PLA) is a biodegradable polyester polymer that is produced from renewable resources, such as corn or other carbohydrate sources. However, its poor toughness limits its commercialization. PLA composites can meet the growing performance needs of various fields, but limited research has focused on their sustainable applications in sports. This paper reviews the latest research on PLA and its composites by describing the characteristics, production, degradation process, and the latest modification methods of PLA. Then, it discusses the inherent advantages of PLA composites and expounds on different biodegradable materials and their relationship with the properties of PLA composites. Finally, the importance and application prospects of PLA composites in the field of sports are emphasized. Although PLA composites mixed with natural biomass materials have not been mass produced, they are expected to be sustainable materials used in various industries because of their simple process, nontoxicity, biodegradability, and low cost.

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“…Formulation technologies such as hot melt extrusion (HME), spray drying, co-precipitation, Kinetisol ® , melt granulation, electro-spinning and electro-spraying processes have been used, some more extensively than others. [12][13][14][15] Amongst all, the HME is widely used because it is a solvent free process, amenable to various downstream processing steps, and the availability of suitable pharmaceutical polymers and solubilizers makes it viable to improve efficacy and safety of the dosage forms. This review highlights the key attributes of HME process, and the polymers suited for this technology.…”

Section: Introductionmentioning

confidence: 99%

Tackling the Challenges with Poorly Soluble Drugs

Ali¹,

Kolter²

2015

JAPLR

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Hot Melt Extrusion: A Process Overview and Use in Manufacturing Solid Dispersions of Poorly Water‐Soluble Drugs

Cited by 4 publications

References 121 publications

Investigations Concerning the Residence Time Distribution of Twin-Screw-Extrusion Processes as Indicator for Inherent Mixing

Investigations Concerning the Residence Time Distribution of Twin-Screw-Extrusion Processes as Indicator for Inherent Mixing

Biodegradable Polylactic Acid and Its Composites: Characteristics, Processing, and Sustainable Applications in Sports

Tackling the Challenges with Poorly Soluble Drugs

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