Hot off the press

Abstract

A personal selection of 31 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as hydrangenone from Salvia hydrangea.

Natural sesquiterpene quinone/quinols: chemistry, biological activity, and synthesis

“…[33][34][35][36][37]79,84,[86][87][88][89][90][91][92][93][94][95][96][97][98][99] Among these compounds, eight were new skeletons, namely, "Dysiarenone," "Septosone," "Frondoplysin," "Dysideanone," "Spiroetherane," and "Dysidavarone," and rated as "hot off the press" by Natural Product Reports. [33][34][35][36][37]97,[100][101][102][103][104] 2.2.1. Typical avarane-type SQs.…”

“…33–37,79,84,86–99 Among these compounds, eight were new skeletons, namely, “Dysiarenone,” “Septosone,” “Frondoplysin,” “Dysideanone,” “Spiroetherane,” and “Dysidavarone,” and rated as “hot off the press” by Natural Product Reports. 33–37,97,100–104…”

Laxiflorol A, the first example of 7,8:15,16-di-seco-15-nor-21-homo-ent-kauranoid from Isodon eriocalyx var. laxiflora

“…2 Ent-kaurane-type diterpenoids represent one of the most excellent examples of natural products with diverse structural scaffolds and important pharmaceutical activities. 2,3 Among these compounds in our library, many unique structures, including ternifolide A, 4 neoadenoloside A, 4 neolaxiorin A, 5 nervonin A, 6 maoecrystal Z, 7 maoecrystal V, 8 xindongnin M, 9 neoangustifolin 10 and epinodosino 10 , have been reported by Natural Product Reports as hot off the press. Some compounds, such as oridonin, 11 eriocalyxin B, 12 adenanthin, 3a pharicin B, 3b and other compounds, have brought great attention to their potential antitumor application.…”

Total Synthesis and Structure Revision of a Fungal Glycolipid Fusaroside

“…Fusaroside 1 is the first member of this novel class of glycolipids containing a branched lipid chain attached to the trehalose core at O-4. 2 In the preliminary studies, fusaroside showed significant growth inhibitory activity against the brine shrimp larvae 1 and is a promising compound for exploring detailed biological activity. 3 Total synthesis of fusaroside is necessary for the procurement of fusaroside and its analogues in the required amounts and purities for structure−activity relationship (SAR) studies, as well as for its structure confirmation.…”

“…The lipid chain also has conjugated double bonds at the C-11 and C-13 positions and an isolated double bond at the C-18 position. Fusaroside 1 is the first member of this novel class of glycolipids containing a branched lipid chain attached to the trehalose core at O-4 . In the preliminary studies, fusaroside showed significant growth inhibitory activity against the brine shrimp larvae and is a promising compound for exploring detailed biological activity .…”