House Dust Mites as a Risk Factor in Chest Allergic Patients in Gharbia Governorate , Egypt

Antonios, Sanaa N; Ashour, Dalia S.; Elkholy, Mohamed G.

doi:10.12816/0004867

Cited by 2 publications

(7 citation statements)

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“…4 Correlation between SPT wheal diameter and specific IgE specific to Der p allergen housekeeping and bird nests, but a non-significant difference between other risk factors. These results agreed with Antonios et al (2012), who reported that 100% of patients had old furniture and old beds with cotton bedding and 90% lived in crowded homes; 60% of cases had a positive family history, and only 15% had pets in their homes. This family history may involve genetic factors and the surrounding environment because all family members are usually exposed to the same environmental conditions regarding humidity and temperature.…”

Section: Discussionsupporting

confidence: 91%

“…The sensitization level to HDM allergens was 22.7% among patients with AR (Moghtaderi et al 2015). Also, Antonios et al (2012) recorded 95% positive reactions to both D. pteronyssinus and D. farinae allergens using SPT among asthmatic patients in Gharbia Governorate, Egypt.…”

Section: Discussionmentioning

confidence: 88%

“…Also, van der Zee et al (1988) reported that there were discrepancies between the results of skin tests and IgE antibody methods showing that more than 80% of these discordances comprised positive skin test reactions in patients with undetectable allergen-specific IgE antibodies in their sera. However, Antonios et al (2012) reported that both SPT and specific IgE tests had sensitivity and specificity of 100% and a positive and negative predictive value of 100% for both D. farinae and D. pteronyssinus. Application of a uniform, practical interpretation of different studies testing the application of both SPT and specific IgE to determine aeroallergen sensitization is difficult because of the availability of several practical methods (e.g., different allergen extracts and skin test devices), differences in study populations and variable analytical tools (Masse et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies supported these results. Antonios et al (2012) reported that there were three times more asthmatic female than male patients, indicating that that bronchial asthma was associated with females with an obvious sex bias. Also, females were reported to have a higher prevalence of asthma than males among preparatory school students in the Al Maadi and Al Maasara regions (Al Dhduh et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Fluctuating levels of specific IgE to HDM allergens among allergic patients in different regions were reported. For instance, in Egypt, Antonios et al (2012) reported that the positive levels of specific IgE to both D. pteronyssinus and D. farinae allergens were 95% among asthmatic patients.…”

Section: Discussionmentioning

confidence: 99%

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House dust mites among allergic patients at the Allergy and Immunology Unit, Zagazig University: an immunologic and serologic study

et al. 2018

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In the twenty-first century, the occurrence of allergic diseases has increased. Prevention and control of house dust mites (HDMs) are required as they play a major role in allergic conditions. The present work aimed to detect HDM allergy ( and ) among allergic patients attending the Allergy and Immunology Unit, Zagazig University. Ninety-six patients with a history of allergic diseases were included in this study. They were examined for allergy to and using different diagnostic tools: the skin prick test (SPT) and measurement of specific IgE antibodies to HDM allergen extracts. Ninety-six allergic patients were recruited in this study [60 females (62.5%) and 36 males (37.5%) aged between 5-60 years]. SPT (81.2 and 79.2%) and IgE (70.9 and 75%) gave positive results for both and , respectively. The common risk factors were use of cotton bedding> 10 years old, older homes > 20 years, crowded homes, family history, home dampness and homes at the ground floor. It was concluded that allergies to contribute to allergic diseases in Zagazig City. Use of the SPT and IgE level is a promising diagnostic tool in the diagnosis of and .

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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House dust mites among allergic patients at the Allergy and Immunology Unit, Zagazig University: an immunologic and serologic study

et al. 2018

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Association between serum zonulin level and severity of house dust mite allergic asthma

Baioumy,

Ibrahim,

Elgendy

et al. 2024

Preprint

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Background: Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, play a critical role in susceptibility to environmental allergens. House dust mites allergy occurs more commonly than any other allergens among Egyptian asthmatic patients. Aim: To assess the relation between serum zonulin level as a marker of increased intestinal permeability and the severity of house dust mites allergic asthma. Methods: A case control study which included 96 subjects attending the allergy and immunology unit, microbiology and immunology department, Faculty of medicine, Zagazig University. They were divided into 48 house dust mites allergic asthma and 48 healthy control subjects. Results: On comparing the 2 studied groups, there was a statistically significant difference between the 2 groups concerning serum IgE and serum zonulin levels ( p=0.000, 0.000 respectively)The mean serum zonulin was equal to 258.3±153.01 ng/ml in the asthmatic group and 80±13 ng/ml in the control group. Serum zonulin level significantly increased with the increase of asthma severity (p˂0.001). The cut off value of serum zonulin was ≥ 198 ng/ml, and the area under the curve was 0.76. It displayed sensitivity equal to 80% and specificity equal to 71.4%. Its negative predictive value was equal to 83.3%. Conclusion: Intestinal barrier dysfunction contributes in the pathogenesis of allergic asthma. Serum zonulin level reflects an increase in intestinal permeability and acts as prognostic factor of severity in Asthma. Correction of the gut barrier defect may be an additional novel approach for Asthma.

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House Dust Mites as a Risk Factor in Chest Allergic Patients in Gharbia Governorate , Egypt

Cited by 2 publications

References 0 publications

House dust mites among allergic patients at the Allergy and Immunology Unit, Zagazig University: an immunologic and serologic study

House dust mites among allergic patients at the Allergy and Immunology Unit, Zagazig University: an immunologic and serologic study

Association between serum zonulin level and severity of house dust mite allergic asthma

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