House Fly Genetics: Isolation of a Female Determining Factor on Chromosome 41

McDonald, Ian C.; Evenson, P.; Nickel, Curtis A.; Johnson, O. A.

doi:10.1093/aesa/71.5.692

Cited by 52 publications

(39 citation statements)

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“…We used the lesions in the Mdtra sequence derived from F man as a molecular signature to assign the location of this gene to a specific chromosome in a multimarked background. The Mdtra variant of the F man allele specifically segregates with markers on chromosome IV (Figure 7B), consistent with the genetic location of F (McDonald et al 1978;Schmidt et al 1997a).…”

Section: F1supporting

confidence: 82%

“…In addition, naturally occurring strains exist where the M factor can be located on any of the five autosomes or even on the X chromosome (Denholm et al 1983;Inoue et al 1983). In some populations, all individuals are homozygous for the M factor, and the female fate is determined by the presence of a dominant female determiner F D (McDonald et al 1978). Even more remarkably, the sex of the housefly can be determined by the maternal genotype.…”

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confidence: 99%

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Molecular Characterization of the Key Switch F Provides a Basis for Understanding the Rapid Divergence of the Sex-Determining Pathway in the Housefly

et al. 2010

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The housefly, Musca domestica, is an excellent model system to study the diversification of the pathway that specifies the sexual fate. A number of different mechanisms have been described in the housefly, which reflects in part the broad diversity of sex-determining strategies used in insects. In this study we present the molecular identification and characterization of F, which acts as the master switch in the housefly pathway. We provide evidence that F corresponds to the transformer ortholog in Musca (Mdtra), which, as a result of alternative processing, expresses functional products only in individuals committed to the female fate. We demonstrate that, once activated, a self-sustaining feedback loop will maintain the female-promoting functions of Mdtra. Absence of Mdtra transcripts in eggs of Arrhenogenic (Ag) mutant females suggests that maternally deployed Mdtra activity initiates this self-sustaining loop in the zygote. When an M factor is paternally transmitted to the zygote, the establishment of the loop is prevented at an early stage before cellularization and splicing of Mdtra shifts irreversibly to the male nonproductive mode. On the basis of the analysis of two mutant alleles we can explain the different sex-determining systems in the housefly largely as deviations at the level of Mdtra regulation. This plasticity in the housefly pathway may provide a suitable framework to understand the evolution of sex-determining mechanisms in other insect species. For instance, while sex determination in a close relative, the tsetse fly Glossina morsitans, differs at the level of the instructive signal, we find that its tra ortholog, Gmtra, is regulated in a mode similar to that of Mdtra.

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Section: F1supporting

confidence: 82%

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confidence: 99%

Molecular Characterization of the Key Switch F Provides a Basis for Understanding the Rapid Divergence of the Sex-Determining Pathway in the Housefly

et al. 2010

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“…Because McDonald et al (1978) demonstrated that an F factor derived from an Australian population was closely linked with Ba locus on chromosome 4, we directly tested whether the hypothetical F factor in the SDF strain is located on the fourth chromosome or not.…”

Section: Resultsmentioning

confidence: 99%

A male-determining factor on autosome 1 and occurrence of male-recombination in the housefly, Musca domestica L..

Inoue

Hiroyoshi

1982

The Japanese journal of genetics

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Linkage analyses of sex-determining factors in a Fijian housefly strain, Suva Dump Fiji (SDF), were performed by using genetically marked autosomes. Although a Y chromosome could not be detected, the presence of at least three kinds of autosomal male-determining factors, IM, IIM and IIIM, was demonstrated in males of this strain. Both males and females of this strain carried the IIM-chromosome in the homozygous state. In addition, the females carried a fourth chromosomal female determining factor (F), which acts epistatically over the plural number of M factors.It is known that no crossing-over occurs in normal XY-type housefly males. However, XX males heterozygous for the IM-chromosome extracted from the SDF strain and a acv by marker chromosome produced recombinants with very low frequency. These recombinants seemed to be the resultants of male crossing-over at the meiotic cell stage. On the basis of male-recombination data, the M factor on the first chromosome was mapped on the right side of by locus.

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“…Construction of F strains for mapping AM factors: Because the F factor is closely linked with the Ba locus on autosome 4 (McDonald et al 1978), it was decided to use Ba as a marker of F. To obtain a recombinant Ba F chromo- Inoue, Fukumori and Hiroyoshi (1983). some, JIM/JIM; + F/+ + females were mated with JIM/11M; + + /Ba + males, and the resulting JIM/JIM; + F/Ba + females were further mated with IIM/ JIM; + +1+ + males. From this cross, 4,326 Ba+ females, 4,011 Ba males, 2 Ba females and 3 Ba+ males were recovered, the recombination frequency being 0.06% between Ba and F. The Ba females, JIM/JIM; Ba F/+ +, were propagated by mating with JIM/JIM; + + / + + males.…”

Section: Methodsmentioning

confidence: 99%

Mapping of autosomal male-determining factors of the housefly, Musca domestica L., by using a female-determining factor.

Inoue

Hiroyoshi

1984

The Japanese journal of genetics

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A procedure to locate autosomal male-determining factors (AM) of the housefly is described, which employs a female-determining factor (F) marked with a closely linked dominant gene. A total of 70 AM chromosomes extracted from four IIM strains, nine IIIM strains and three VM strains of different geographic origins were examined.On the basis of female recombination frequencies, two to three types of AM chromosomes were found in each of the linkage groups, suggesting that the AM chromosomes are polymorphic for chromosome aberrations.All the AM factors were mapped to a specific site or closely linked sites on the respective autosomes. From the comparison of the mitotic autosome figures and the female recombination maps of AM chromosomes, it is suggested that AM factors are located near the centromeres of autosomes. The validity of this technique and the possible mechanisms for the origin of M polymorphism are discussed.

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House Fly Genetics: Isolation of a Female Determining Factor on Chromosome 41

Cited by 52 publications

References 0 publications

Molecular Characterization of the Key Switch F Provides a Basis for Understanding the Rapid Divergence of the Sex-Determining Pathway in the Housefly

Molecular Characterization of the Key Switch F Provides a Basis for Understanding the Rapid Divergence of the Sex-Determining Pathway in the Housefly

A male-determining factor on autosome 1 and occurrence of male-recombination in the housefly, Musca domestica L..

Mapping of autosomal male-determining factors of the housefly, Musca domestica L., by using a female-determining factor.

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