Household Versus Individual Approaches to Eradication of Community-Associated Staphylococcus aureus in Children: A Randomized Trial

Abstract

NCT00731783.

Incidence and recurrence of boils and abscesses within the first year: a cohort study in UK primary care

“…24 More recently, community studies from the US have shown decolonisation may reduce the risk of recurrent boils and abscesses, particularly when an entire household is treated simultaneously. 14,15 However there is little consensus on how decolonisation should be undertaken in the community or how to manage patients with recurrent boils who remain persistently colonised despite treatment.…”

“…12,13 However, the effectiveness of such interventions is questionable and they are resource intensive. 14,15 There is a clear need for guidance on how to manage patients with recurrent disease in the community. The aim of this study was to determine the burden of recurrent disease and identify opportunities for secondary prevention in these patients.…”

Measurement and Impact of Staphylococcus aureus Colonization Pressure in Households

“…Informed consent was obtained at study enrollment for cases and household contacts. Patients aged 6 months to 20 years with SSTI were screened from May 2008 to December 2009 from the Emergency Department and ambulatory wound center of St Louis Children's Hospital (SLCH) and from 9 community pediatric practices affiliated with a practice-based research network in metropolitan St Louis, MO [22]. Patients with traditional healthcare-associated S aureus risk factors (indwelling catheter or percutaneous medical device, post-operative wound infection, on dialysis, or residence in a long-term care facility) were excluded from screening.…”

“…Patients with traditional healthcare-associated S aureus risk factors (indwelling catheter or percutaneous medical device, post-operative wound infection, on dialysis, or residence in a long-term care facility) were excluded from screening. To detect colonization of cases, culture swabs (BBL Liquid Stuart; Becton Dickinson, Sparks, MD) were obtained at the time of screening from the anterior nares, axillae, and inguinal folds as described previously [22,23]. To confirm the presence of an S aureus infection, wound culture results were obtained from the SLCH microbiology laboratory or the relevant provider's office.…”

“…Patients both colonized and infected with S aureus (MRSA or methicillin-susceptible S aureus [MSSA]) were eligible for enrollment in a decolonization trial and were invited to return to SLCH for an enrollment visit. At the time of enrollment, the colonization status of household contacts was assessed by culturing their anterior nares, axillae, and inguinal folds as described previously [22]. A household contact was defined as a person who spent more than half of each week in the primary household of the case.…”