This study constructs a theoretical framework to analyze the impact of local government‐led construction land supply (LGCLS) strategies on urban innovation. It uses data related to 265 cities in China from 2005 to 2019 for empirical analysis. Its conclusions are as follows. For development stage differences, the impact of LGCLS strategies on urban innovation exhibited an inverted U shape with economic growth. The inflection point occurred when the per capita GDP equaled approximately RMB23,101 in 2008. For regional differences, the inflection point in eastern China is higher and earlier than that in central and western China; before the inflection point, the positive influence was more obvious in the central and western regions, whereas after the inflection point, the negative influence was more obvious in the eastern region. For the eastern Yangtze River Delta urban agglomerations and the northwestern resource‐based urban agglomerations with relatively high per capita GDP, the negative impact of LGCLS strategies on urban innovation occurred earlier and showed spatial agglomeration characteristics.