Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress

Engeln, Michel; Fox, Megan E.; Lobo, Mary Kay

doi:10.1007/s00213-020-05657-y

Cited by 16 publications

(23 citation statements)

References 70 publications

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“…Environmental enrichment attenuates yohimbine-induced reinstatement of cocaine seeking following selfadministration in rats (Chauvet et al, 2009). The ability of social defeat stress to promote cocaine seeking in mice is heightened when mice are isolated during self-administration (Engeln et al, 2021).…”

Section: Other Factorsmentioning

confidence: 99%

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Caccamise

Newenhizen

Mantsch

2021

Journal of Neurochemistry

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In individuals with substance use disorders, stress is a critical determinant of relapse susceptibility. In some cases, stressors directly trigger cocaine use. In others, stressors interact with other stimuli to promote drug seeking, thereby setting the stage for relapse. Here, we review the mechanisms and neurocircuitry that mediate stress-triggered and stress-potentiated cocaine seeking. Stressors trigger cocaine seeking by activating noradrenergic projections originating in the lateral tegmentum that innervate the bed nucleus of the stria terminalis to produce beta adrenergic receptor-dependent regulation of neurons that release corticotropin releasing factor (CRF) into the ventral tegmental area (VTA). CRF promotes the activation of VTA dopamine neurons that innervate the prelimbic prefrontal cortex resulting in D1 receptor-dependent excitation of a pathway to the nucleus accumbens core that mediates cocaine seeking. The stage-setting effects of stress require glucocorticoids, which exert rapid non-canonical effects at several sites within the mesocorticolimbic system. In the nucleus accumbens, corticosterone attenuates dopamine clearance via the organic cation transporter 3 to promote dopamine signaling. In the prelimbic cortex, corticosterone mobilizes the endocannabinoid, 2-arachidonoylglycerol (2-AG), which produces CB1 receptor-dependent reductions in inhibitory transmission, thereby increasing excitability of neurons which comprise output pathways responsible for cocaine seeking. Factors that influence the role of stress in cocaine seeking, including prior history of drug use, biological sex, chronic stress/co-morbid stress-related disorders, adolescence, social variables, and genetics are discussed.Better understanding when and how stress contributes to drug seeking should guide the development of more effective interventions, particularly for those whose drug use is stress related.

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Section: Other Factorsmentioning

confidence: 99%

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Caccamise

Newenhizen

Mantsch

2021

Journal of Neurochemistry

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“…Importantly, our mice were pair-housed throughout the fentanyl procedure. Previously (Engeln et al, 2021), we showed that when mice are single-housed, CSDS-susceptibility is associated with increased early cocaine self-administration. When pair-housed, CSDS instead decreases cocaine selfadministration, analogous to increased anhedonia.…”

Section: Discussionmentioning

confidence: 91%

“…Numerous studies demonstrate psychosocial stress exerts differential effects on drugabuse-like behavior (Neisewander et al, 2012;Newman et al, 2018). Previously, we showed individual stress-response impacts cocaine self-administration (Engeln et al, 2021). To test the hypothesis that susceptibility to psychosocial stress increases homecage opioid consumption, we subjected mice to chronic witness defeat (CWDS) or social defeat stress (CSDS) (Timeline and schematic in Fig 1A ).…”

Section: Resultsmentioning

confidence: 99%

“…For example in rats, brief social stress increases cocaine self-administration and motivation for cocaine (Haney et al, 1995;Tidey and Miczek, 1997;Covington and Miczek, 2001;Burke and Miczek, 2015), while prolonged social stress reduces cocaine self-administration (Miczek et al, 2011). In mice, prolonged social stress either promotes or suppresses cocaine self-administration (Yap and Miczek, 2007;Han et al, 2015Han et al, , 2017Arena et al, 2019) but we recently showed this depends on social housing conditions (Engeln et al, 2021). There are comparatively fewer studies on psychosocial stress and opioid self-administration.…”

Section: Introductionmentioning

confidence: 92%

“…Social stress was performed as in our previous work (Fox et al, 2020a(Fox et al, , 2020bEngeln et al, 2021;Morais-Silva et al, 2021), by using the modifications described in (Warren et al, 2013;Iñiguez et al, 2018) for vicarious resident-intruder stress. In chronic social defeat stress (CSDS), a male mouse (intruder) is physically defeated by an aggressive CD-1 (resident) for 10 min in a hamster cage containing woodchip bedding and a perforated divider.…”

Section: Chronic Social Stressmentioning

confidence: 99%

See 2 more Smart Citations

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

Franco

Wulff

Lobo

et al. 2021

Preprint

Self Cite

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Chronic stress can increase the risk of developing a substance use disorder in vulnerable individuals. Numerous models have been developed to probe the underlying neurobiological mechanisms, however most prior work has been restricted to male rodents, conducted only in rats, or introduces physical injury that can complicate opioid studies. Here we sought to establish how chronic psychosocial stress influences fentanyl consumption in male and female C57BL/6 mice. We used chronic social defeat stress (CSDS), or the modified vicarious chronic witness defeat stress (CWDS), and used social interaction to stratify mice as stress-susceptible or resilient. We then subjected mice to a 15 day fentanyl drinking paradigm in the home cage that consisted of alternating forced and choice periods with increasing fentanyl concentrations. Male mice susceptible to either CWDS or CSDS consumed more fentanyl relative to unstressed mice, and exhibited increased preference for fentanyl. CWDS-susceptible female mice did not differ from unstressed mice during the forced periods, but showed increased preference for fentanyl. We also found decreased expression of nucleus accumbens Rho GTPases in male, but not female mice following stress and fentanyl drinking. We also compare fentanyl drinking behavior in mice that had free access to plain water throughout. Our results indicate that stress-sensitized fentanyl consumption is dependent on both sex and behavioral outcomes to stress.

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Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system

et al. 2022

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Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress

Cited by 16 publications

References 70 publications

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system

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