Housing temperature affects the acute and chronic metabolic adaptations to exercise in mice

McKie, Greg L.; Medak, Kyle D.; Knuth, Carly M.; Shamshoum, Hesham; Townsend, Logan K.; Peppler, Willem T.; Wright, David C.

doi:10.1113/jp278221

Cited by 77 publications

(85 citation statements)

References 91 publications

(109 reference statements)

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“…Results of the GTT (Figure 1d) indicated a nonsignificant trend (p = .052) in glucose tolerance between groups. Exercise is well known to increase skeletal muscle oxidative capacity McKie et al, 2019;Stanford, Middelbeek, & Goodyear, 2015) and in the current study, we observed consistent exercise-induced increases in the protein content of HKII (p < .001), CYTO C, COX IV, and PGC1α (p < .05; Figure 1e) in the triceps muscle.…”

Section: Days Of Vwr Exercise Training Attenuates Weight Gain Desupporting

confidence: 85%

Epinephrine responsiveness is reduced in livers from trained mice

et al. 2020

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The liver is the primary metabolic organ involved in the endogenous production of glucose through glycogenolysis and gluconeogenesis. Hepatic glucose production (HGP) is increased via neural‐hormonal mechanisms such as increases in catecholamines. To date, the effects of prior exercise training on the hepatic response to epinephrine have not been fully elucidated. To examine the role of epinephrine signaling on indices of HGP in trained mice, male C57BL/6 mice were either subjected to 12 days of voluntary wheel running or remained sedentary. Epinephrine, or vehicle control, was injected intraperitoneally on day 12 prior to sacrifice with blood glucose being measured 15 min postinjection. Epinephrine caused a larger glucose response in sedentary mice and this was paralleled by a greater reduction in liver glycogen in sedentary compared to trained mice. There was a main effect of epinephrine to increase the phosphorylation of protein kinase‐A (p‐PKA) substrates in the liver, which was driven by increases in the sedentary, but not trained, mice. Similarly, epinephrine‐induced increases in the mRNA expression of hepatic adrenergic receptors (Adra1/2a, Adrb1), and glucose‐6‐phosphatase (G6pc) were greater in sedentary compared to trained mice. The mRNA expression of cAMP‐degrading enzymes phosphodiesterase 3B and 4B (Pde3b, Pde4b) was greater in trained compared to sedentary mice. Taken together, our data suggest that prior exercise training reduces the liver's response to epinephrine. This could be beneficial in the context of training‐induced glycogen sparing during exercise.

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Section: Days Of Vwr Exercise Training Attenuates Weight Gain Desupporting

confidence: 85%

Epinephrine responsiveness is reduced in livers from trained mice

et al. 2020

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“…This study has a potential limitation: Recent work (McKie et al, 2019;Raun et al, 2020) has demonstrated that housing mice at subthermal neutral conditions, that is, room temperature, rather than at thermal neutrality can stimulate increases in mitochondrial and thermogenic proteins in adipose tissues with endurance exercise training. Housing temperature (22-24°C) may have impacted our data because the thermoneutral zone of Wistar rats is in the range of 29.5-30.5°C (Romanovsky, Ivanov, & Shimansky, 2002).…”

Section: Discussionmentioning

confidence: 99%

Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats

et al. 2020

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Chronic endurance exercise training induces morphological and metabolic alterations including mitochondrial biogenesis in white adipose tissue (WAT) and brown adipose tissue (BAT) in rodents. A myokine called meteorin‐like (Metrnl) is associated with morphological and metabolic adaptation and increased in blood after acute resistance exercise. However, the effects of chronic resistance exercise training (RT), which aims to increase muscle mass and strength, on WAT and BAT are unclear. Therefore, we aimed to clarify the effects of RT on morphological and metabolic parameters in WAT and BAT and on plasma Metrnl concentrations. We applied electrical stimulation to both legs of rats as RT three times a week for 4 weeks. RT reduced adipocyte size in subcutaneous WAT but induced no changes in mitochondrial and thermogenesis proteins. In BAT, peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α) protein levels and mitochondrial content markers were significantly higher in the RT group compared with the control group. A significant positive correlation was found between the expression of PGC‐1α in BAT and plasma Metrnl concentrations. These results suggest that plasma Metrnl is associated with PGC‐1α and mitochondrial biogenesis in BAT. This study describes a potential role of RT in preventing metabolic diseases via altering WAT and BAT and increasing plasma Mertnl concentrations.

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“…Although not statistically significant, the total running distance completed at 29°C was still ∼20% higher ( P = 0.0614) after the intervention (McKie et al . ). However, the time spend on the wheel was the same at both temperatures, so the mice housed in thermoneutral conditions must have been running at a higher intensity.…”

Section: Perspectivesmentioning

confidence: 97%

“…In a recently published paper in The Journal of Physiology , McKie et al . () undertook a detailed description of the importance of housing temperature in exercise training‐induced adaptations of adipose tissue in mice.…”

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confidence: 99%